Origin of the New Caledonian bryophytes

The origin of a flora is one of the most interesting and challenging topics in bryology. However, it is a very difficult problem, and considerable effort is needed to accumulate more detailed information on the distribution and taxonomy of bryophytes than is available today

Cyclosporin a hepatotoxicity in 66 renal allograft recipients

Liver functional abnormalities were seen in 13 (19.7%) of 66 recipients of cadaveric renal homografts treated with cyclosporin A and prednisone. However, such presumed hepatotoxicity was a minor problem in the use of cyclosporin A. The complication was less frequent than that of nephrotoxicity, was as easily manageable with reductions in the cyclosporin A dosage, and generally did not cause clinical illness. In an occasional case, late hepatotoxicity can force a therapeutic change from cyclosporin A to azathioprine, but careful consideration should be given to the dangers of subsequent rejection. © 1981 by The Williams and Wilkins Co