[Le sauropode dinosaurien Cetiosaurus OWEN dans le Bathonien (Jurassique Moyen) des Ardennes (NE France) : insulaire, mais pas nain]

Un os chevron provenant d'un calcaire oolithique du Bathonien inférieur des Ardennes (NE de la France) est rapporté au dinosaure sauropode Cetiosaurus OWEN, connu précédemment dans le Jurassique moyen d'Angleterre, à cause de son extrémité distale en baguette. C'est le premier indice bien attesté de la présence de Cetiosaurus en France. La présence de restes de Cetiosaurus à la fois dans l'Oxfordshire et dans les Ardennes s'explique par le fait que ces régions étaient situées sur la marge du Massif Londres-Brabant, terre émergée sur laquelle vivaient apparemment des populations de dinosaures. Contrairement au cas d'autres sauropodes dans des environnements insulaires, il n'y a pas de traces de nanisme chez les Cetiosaurus du Massif Londres-Brabant, probablement parce que cette terre émergée était connectée au Bouclier Fenno-Scandien, beaucoup plus vaste.A chevron bone from a Lower Bathonian oolitic limestone in the Ardennes (NE France) is referred to the sauropod dinosaur Cetiosaurus OWEN, previously known from the Middle Jurassic of England, on the basis of its rod-like distal end. This is the first well attested occurrence of Cetiosaurus in France. The presence of Cetiosaurus remains in the Bathonian of both Oxfordshire and the Ardennes is explainable by the fact that these regions were situated on the margin of the London-Brabant Massif land area, on which sauropod populations apparently lived. Contrary to the condition observed in other sauropods found in insular environments, there is no evidence of dwarfism in Cetiosaurus from the London-Brabant Massif, probably because this emergent area was connected to the much larger Fenno-Scandian Shield

ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

publishedVersio

Neurological manifestations of COVID-19 in adults and children

Different neurological manifestations of coronavirus disease 2019 (COVID-19) in adults and children and their impact have not been well characterized. We aimed to determine the prevalence of neurological manifestations and in-hospital complications among hospitalized COVID-19 patients and ascertain differences between adults and children. We conducted a prospective multicentre observational study using the International Severe Acute Respiratory and emerging Infection Consortium (ISARIC) cohort across 1507 sites worldwide from 30 January 2020 to 25 May 2021. Analyses of neurological manifestations and neurological complications considered unadjusted prevalence estimates for predefined patient subgroups, and adjusted estimates as a function of patient age and time of hospitalization using generalized linear models. Overall, 161 239 patients (158 267 adults; 2972 children) hospitalized with COVID-19 and assessed for neurological manifestations and complications were included. In adults and children, the most frequent neurological manifestations at admission were fatigue (adults: 37.4%; children: 20.4%), altered consciousness (20.9%; 6.8%), myalgia (16.9%; 7.6%), dysgeusia (7.4%; 1.9%), anosmia (6.0%; 2.2%) and seizure (1.1%; 5.2%). In adults, the most frequent in-hospital neurological complications were stroke (1.5%), seizure (1%) and CNS infection (0.2%). Each occurred more frequently in intensive care unit (ICU) than in non-ICU patients. In children, seizure was the only neurological complication to occur more frequently in ICU versus non-ICU (7.1% versus 2.3%, P < 0.001). Stroke prevalence increased with increasing age, while CNS infection and seizure steadily decreased with age. There was a dramatic decrease in stroke over time during the pandemic. Hypertension, chronic neurological disease and the use of extracorporeal membrane oxygenation were associated with increased risk of stroke. Altered consciousness was associated with CNS infection, seizure and stroke. All in-hospital neurological complications were associated with increased odds of death. The likelihood of death rose with increasing age, especially after 25 years of age. In conclusion, adults and children have different neurological manifestations and in-hospital complications associated with COVID-19. Stroke risk increased with increasing age, while CNS infection and seizure risk decreased with age

Les enseignements de DUNE: Enjeux actuels dans l'oeuvre phare de Frank Herbert

International audienc

Syndrome de Sneddon (difficultés diagnostiques et thérapeutiques, à propos de deux observations)

PARIS7-Xavier Bichat (751182101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

A rare case of cytomegalovirus induced oral ulcer in an immunocompromised patient

Introduction: Oral manifestations of cytomegalovirus are rare. Observation: We report the case of an atypical and persistent oral location of cytomegalovirus, in the form of ulcers, in a patient suffering from granulomatosis with polyangiitis and treated by rituximab. Discussion: In front of a chronic ulcer, a differential diagnosis must be made to exclude different etiologies, by order of severity, frequency or according to the clinical situation of the patient. The main differential diagnosis that must be excluded is a squamous-cell carcinoma. Conclusion: Cytomegalovirus ulcers are not specific and its etiology cannot be affirmed clinically. A pathological examination is essential to allow the quick establishing of a treatment in an immuno-compromised patient to prevent further complications.</jats:p

A rare case of cytomegalovirus induced oral ulcer in an immunocompromised patient

Introduction: Oral manifestations of cytomegalovirus are rare. Observation: We report the case of an atypical and persistent oral location of cytomegalovirus, in the form of ulcers, in a patient suffering from granulomatosis with polyangiitis and treated by rituximab. Discussion: In front of a chronic ulcer, a differential diagnosis must be made to exclude different etiologies, by order of severity, frequency or according to the clinical situation of the patient. The main differential diagnosis that must be excluded is a squamous-cell carcinoma. Conclusion: Cytomegalovirus ulcers are not specific and its etiology cannot be affirmed clinically. A pathological examination is essential to allow the quick establishing of a treatment in an immuno-compromised patient to prevent further complications

In vivo and in vitro studies on estetrol for prevention and treatment of sensorineural hearing loss

peer reviewedaudience: researche

La nouvelle constellation politique franco-allemande : un nouveau souffle pour l’Europe ?

Isabelle Bourgeois : Je souhaiterais introduire ce débat par une citation : « Cinq ans seulement après la Deuxième Guerre mondiale, le ministre français des Affaires étrangères, Robert Schuman, proposait à ses partenaires européens d’instituer la Communauté Européenne du Charbon et de l’Acier (CECA). La France et l’Allemagne devenaient ainsi le grand moteur de la construction européenne. Les adversaires d’hier devenaient des partenaires ». Ce passage est extrait d’un discours tenu par le prés..