Influence of fingerprints and finger positioning on accuracy of RF blood glucose measurement from fingertips

Non-invasive blood glucose measurement has attracted great interest from researchers deploying various techniques where microwave sensing is one of them. Microwave resonators are utilized as sensors for measuring the glucose levels. A body part is placed on the sensor for a reading and the measurement principle lies in the change of the dielectric properties of blood with varying levels of glucose. The fingertip is a popular measurement site as there is a good amount fresh blood supply. The position of the fingertip on the sensor has an effect on the sensor response due to the change in the propagation path of the electromagnetic field inside the finger. Moreover, fingerprints also affect the sensor response as the irregular ridges and valleys in the fingerprint introduce air gaps altering the effective permittivity seen by the sensor. The effects of fingerprints as well as finger positioning on the sensor is explored and explained in this paper

Effect on Glycemic, Blood Pressure, and Lipid Control according to Education Types

BackgroundDiabetes self-management education and reinforcement are important for effective management of the disease. We investigated the effectiveness of interactive small-group education on glycemic, blood pressure, and lipid levels.MethodsFor this study, 207 type 2 diabetes patients with suboptimal glycemic control (HbA1c levels >6.5%) were enrolled. The conventional education group received an existing education program from April to November in 2006, and the interactive education group received a new small-group education program from December 2006 to July 2007. The two groups were comparatively analyzed for changes in blood sugar, glycated hemoglobin, lipid, and blood pressure at baseline, 3, 6, and 12 months and the proportion of patients achieving target goals at 12 months.ResultsAfter 12 months of follow-up, HbA1c levels in the interactive education group were significantly lower than in the conventional education group (6.7% vs. 6.4%, P<0.001). Fasting and 2 hour postprandial glucose concentrations, total cholesterol, and low density lipoprotein cholesterol were significantly lower in the interactive education group than in the conventional education group. The proportion of patients that achieved target goals was significantly higher in the interactive education group.ConclusionThe small-group educational method improved and re-established the existing group educational method. This finding suggests that the importance of education appears to be related to the method by which it is received rather than the education itself. Thus, the use of small-group educational methods to supplement existing educational methods established for diverse age levels should be considered in the future

Біоіндикація інтенсивності забруднення довкілля за показниками фертильності пилкових зерен різних рослин

Досліджено гонадотоксичні ефекти факторів довкілля різних районів Івано-Франківської області за показниками фертильності пилкових зерен чотирьох видів рослин. Встановлено зниження фертильності пилкових зерен рослин з хімічно забруднених міст Калуша та Бурштина і зони посиленого радіологічного контролю (села Стецева Снятинського району) порівняно з показником у рослин з відносно екологічно чистих міст Яремча та Косів. Тест на стерильність пилку може використовуватись як один з біоіндифікаційних показників забруднення довкілля.Gonadotoxic effects of the environmental factors in different districts of Ivano-Frankivsk region according to fertility indices of pollen plants of four kinds have been investigated. The reduction of the pollen plants seeds fertility from such chemically polluted towns as Kalush and Bershtyn and the region of a doubled radiologic control (Stetseva village, Snyatyn district) in comparison with the same plants from the eco-friendly towns of Yaremcha and Kosiv has been noticed. The pollen sterility test may be used as one of the bioindicative indices of the environmental pollution

Making diabetes education interactive : tangible educational toys for children with type-1 diabetes

Younger children (under 9 years) with type-1 diabetes are often very passive in the management of their condition and can face difficulties in accessing and understanding basic diabetes related information. This can make transitioning to self-management in later years very challenging. Previous research has mostly focused on educational interventions for older children. To create an educational tool which can support the diabetes educational process of younger children, we conducted a multiphase and multi-stakeholder user-centred design process. The result is an interactive tool that illustrates diabetes concepts in an age-appropriate way with the use of tangible toys. The tool was evaluated inside a paediatric diabetes clinic with clinicians, children and parents and was found to be engaging, acceptable and effective. In addition to providing implications for the design and adoption of educational tools for children in a clinical setting, we discuss the challenges for conducting user-centred design in such a setting

The associations of sedentary time and breaks in sedentary time with 24-hour glycaemic control in type 2 diabetes

The aim of this study was to investigate the associations of accelerometer-assessed sedentary time and breaks in sedentary time with 24-h events and duration of hypoglycaemia (7.8 mmol/l) and above target glucose (>9 mmol/l). Thirty-seven participants with type 2 diabetes (age, 62.8 ± 10.5 years; body mass index, 29.6 ± 6.8 kg/m2) in Glasgow, United Kingdom were enrolled between February 2016 and February 2017. Participants wore an activity monitor (activPAL3) recording the time and pattern of sedentary behaviour and a continuous glucose monitoring (CGM, Abbott FreeStyle Libre) for up to 14 days. Linear regression analyses were used to investigate the associations. Participants spent 3.7%, 64.7%, 32.1% and 19.2% of recording h/day in hypoglycaemia, euglycaemia, hyperglycaemia and above target, respectively. There was a negative association between sedentary time and time in euglycaemia (β = -0.44, 95% CI -0.86; -0.03, p = 0.04). There was a trend towards a positive association between sedentary time and time in hyperglycaemia (β = 0.36, 95% CI -0.05; 0.78, p = 0.08). Breaks in sedentary time was associated with higher time in euglycaemia (β = 0.38, 95% CI 0.00; 0.75, p = 0.04). To conclude, in individuals with type 2 diabetes, more time spent in unbroken and continuous sedentary behaviour was associated with poorer glucose control. Conversely, interrupting sedentary time with frequent breaks appears to improve glycaemic control. Therefore, this should be considered as a simple adjunct therapy to improve clinical outcomes in type 2 diabetes

Exploring the acceptability and feasibility of a preconception and diabetes information app for women with pregestational diabetes: A mixed-methods study protocol

Background Women with diabetes are at increased risk of adverse maternal and fetal outcomes. Preconception care can improve pregnancy outcomes and is paramount to minimise complications, but, current provision is sub-optimal. Mobile technology, particularly smartphones and apps have the potential to improve preconception care provision but research is lacking in this area. The need to use modern technologies to improve preconception care knowledge and awareness led to the development of a Preconception and Diabetes Information app in stage A of this study. Objective The aim of this paper, stage B of the study, is to explore the feasibility and acceptability of the Preconception and Diabetes Information app to improve preconception care knowledge and attitudes in women with diabetes, and explore the potential for wider implementation. Methods A mixed methods study design adopting a quasi-experimental approach will assess women’s knowledge and attitudes related to preconception care, and level of patient activation (knowledge and confidence for self-management of health) before and after the 3 month intervention period. A log of activity will be used to determine engagement with the app and semi-structured interviews will explore women’s experiences. Conclusions This is the first study to explore the acceptability and feasibility of a Preconception and Diabetes Information app for women with diabetes. The app has potential to change the way preconception care is delivered, improve pregnancy outcomes and be widely implemented in both developed and developing countries. This is important given the considerable shortfalls in current preconception care services in the United Kingdom and around the world

Superimposition of eye fundus images for longitudinal analysis from large public health databases

In this paper, a method is presented for superimposition (i.e. registration) of eye fundus images from persons with diabetes screened over many years for diabetic retinopathy. The method is fully automatic and robust to camera changes and colour variations across the images both in space and time. All the stages of the process are designed for longitudinal analysis of cohort public health databases where retinal examinations are made at approximately yearly intervals. The method relies on a model correcting two radial distortions and an affine transformation between pairs of images which is robustly fitted on salient points. Each stage involves linear estimators followed by non-linear optimisation. The model of image warping is also invertible for fast computation. The method has been validated (1) on a simulated montage and (2) on public health databases with 69 patients with high quality images (271 pairs acquired mostly with different types of camera and 268 pairs acquired mostly with the same type of camera) with success rates of 92% and 98%, and five patients (20 pairs) with low quality images with a success rate of 100%. Compared to two state-of-the-art methods, ours gives better results.Comment: This is an author-created, un-copyedited version of an article published in Biomedical Physics \& Engineering Express. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The Version of Record is available online at https://doi.org/10.1088/2057-1976/aa7d1

Genetic variation in insulin‐induced kinase signaling

Individual differences in sensitivity to insulin contribute to disease susceptibility including diabetes and metabolic syndrome. Cellular responses to insulin are well studied. However, which steps in these response pathways differ across individuals remains largely unknown. Such knowledge is needed to guide more precise therapeutic interventions. Here, we studied insulin response and found extensive individual variation in the activation of key signaling factors, including ERK whose induction differs by more than 20‐fold among our subjects. This variation in kinase activity is propagated to differences in downstream gene expression response to insulin. By genetic analysis, we identified cis‐acting DNA variants that influence signaling response, which in turn affects downstream changes in gene expression and cellular phenotypes, such as protein translation and cell proliferation. These findings show that polymorphic differences in signal transduction contribute to individual variation in insulin response, and suggest kinase modulators as promising therapeutics for diseases characterized by insulin resistance.SynopsisGenetic variants contribute to individual variation in insulin response, including kinase activation, changes in gene expression and cell growth, suggesting kinase modulators as promising therapeutics for diseases characterized by insulin resistance.Extensive individual variation is observed in insulin‐induced activation of signal transduction.The variation in signaling response is propagated downstream to influence gene expression and cell growth.There is a genetic component to the individual differences in signaling and gene expression response to insulin.Genetic variants contribute to individual variation in insulin response, including kinase activation, changes in gene expression and cell growth, suggesting kinase modulators as promising therapeutics for diseases characterized by insulin resistance.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/112224/1/msb156250-sup-0001-EVFigs.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/112224/2/msb156250.reviewer_comments.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/112224/3/msb156250.pd