Wavelength-Conversion-Material-Mediated Semiconductor Wafer Bonding for Smart Optoelectronic Interconnects

A new concept of semiconductor wafer bonding, mediated by optical wavelength conversion materials, is proposed and demonstrated. The fabrication scheme provides simultaneous bond formation and interfacial function generation, leading to efficient device production. Wavelength-converting functionalized semiconductor interfacial engineering is realized by utilizing an adhesive viscous organic matrix with embedded fluorescent particles. The bonding is carried out in ambient air at room temperature and therefore provides a cost advantage with regard to device manufacturing. Distinct wavelength conversion, from ultraviolet into visible, and high mechanical stabilities and electrical conductivities in the bonded interfaces are verified, demonstrating their versatility for practical applications. This bonding and interfacial scheme can improve the performance and structural flexibility of optoelectronic devices, such as solar cells, by allowing the spectral light incidence suitable for each photovoltaic material, and photonic integrated circuits, by delivering the respective preferred frequencies to the optical amplifier, modulator, waveguide, and detector materials

Investigation of The Cause of Death in Inpatients with Dementia in Akitsu Konoike Hospital.

The mortality rate of patients with dementia is known to be higher than that of the general population. Pneumonia is one of the most common causes of death in patients with dementia, and proper intervention is important for clinical outcomes. To date, it remains unclear whether there are differences in the risk factors of pneumonia among different types of dementia. Here, we investigated the primary cause of death in patients with dementia admitted at Akitsu Konoike Hospital. Furthermore, Cox regression analyses were performed to evaluate the risk factors associated with death by pneumonia among patients with Alzheimer's dementia (AD), vascular dementia (VaD), and other conditions. We found that pneumonia was one of the most common causes of death in all of the current samples. Additionally, poor outcomes were associated with the Barthel index in AD and aging or short disease duration in VaD. These results suggest that considering the diagnostic differences in death by pneumonia is important for clinical treatment of patients with dementia

Macroscopic findings for breast VAB specimens

Purpose : Ultrasound-guided breast tissue biopsy is an essential technique for diagnosing breast disease, but sample errors reduce its accuracy. This study investigated whether the histopathological results can be inferred from the macroscopic findings for Ultrasound-guided breast Vacuum Assisted Biopsy (VAB) specimens. Methods: Biopsy specimens from 101 patients who underwent mammary gland VAB were photographed with a smartphone, and the relationships between the macroscopic findings and the pathological results were examined. Results : A significant difference was observed with regard to the presence / absence of turbidity: malignancy was detected in 33 / 37 (89%) specimens with turbidity and in 2 / 47 (4%) cases without turbidity (p < 0.001). A significant difference was also observed regarding the surface properties : malignancy was detected in 14 / 70 (19%) smooth specimens and in 24 / 29 (83%) rough specimens (p < 0.001). Also, malignancy was detected in 11 / 13 (85%) specimens with white spots, and the difference was significant (p < 0.001). In addition, the characteristics of intraductal papilloma, fibroadenoma, and mastopathy could be confirmed by macroscopic findings. Conclusions : When needle–biopsy of a lesion that is targeted for resection yields macroscopic findings that match the predicted histopathological findings, it can be thought that the biopsy had been properly performed. This means that false–negatives due to poor specimens can be prevented

Ka-Band Multi-Gbps High Speed Downlink With Electrically Steerable Beam

With advances in sensor technology and data services, the latest earth observation missions tend to require substantial amounts of remote sensing data to be downlinked to earth stations with shorter delivery times. To meet these demands, AXELSPACE is developing a Ka-band downlink system (AxelLink-Ka) in cooperation with Tokyo Institute of Technology 1 that combines a broadband Ka-band transmitter and an active phased array antenna.2 The prototype of the AxelLink-Ka was found to achieve a data rate of up to 4.2 Gbps with using dual polarizaion of Right- and Left-Handed Circular Polarization (RHCP/LHCP) in the Ka-band (25.5—27.0 GHz) and electrical beam steering covering ±66-degree range with the small enough Size, Weight and Power (SWaP) to be installed on a microsatellite: the size ∼ 220 × 170 × 100 mm, the weight \u3c 2, 300g, and the power consumption \u3c 60 W. This paper provides an overview of the entire system, simulation results of link budgets, and design and measurement results of the hardware and software

DIP during perioperative chemotherapy

Purpose : Drug-induced interstitial pneumonia (DIP) that occurs during chemotherapy for breast cancer is a rare but a serious adverse event. Treatments of DIP requires interruption of breast cancer treatment, which may affect the patient’s prognosis. However, there are few reports which discuss DIP during breast cancer treatments. Purpose of this report is to make clear how DIP occurred and influenced breast cancer treatment in our hospital. Patients and Methods : A total of 74 patients who started perioperative chemotherapy in Tokushima Municipal Hospital for breast cancer from January 2019 to December 2020 were evaluated for DIP. Patients’ and tumors’ characteristics, and regimens which caused DIP were investigated. The clinical courses of the DIP patients were also followed up. Results : Twelve of the 74 patients developed DIP. All 12 patients had histories of cyclophosphamide administration ; however, the causative drug could not be determined. Ten of the 12 patients were treated with steroids, and all the patients recovered ultimately from the interstitial pneumonia. While chemotherapy was administered in six patients after mild DIP, no relapse of pneumonia was observed. Conclusion : DIP during perioperative chemotherapy for breast cancer was resolved with appropriate treatment. Patients were able to resume breast cancer treatment with minimal interruption

Adipose-derived regenerative cells exert beneficial effects on systemic responses following myocardial ischemia/reperfusion

Background: Acute coronary syndrome leads to systemic responses, including activation of the sympathetic nervous system, inflammation of atherosclerotic lesions, changes in metabolism and gene expressions of remote organs such as the spleen, bone marrow, and liver. Clinical trials and experimental studies have demonstrated that therapy with adipose-derived regenerative cells (ADRCs) attenuates myocardial ischemia/reperfusion (I/R) injury. The aim of this study is to investigate the role of ADRCs in regulating systemic reactions following I/R.Methods: Isolated ADRCs were obtained from green fluorescent protein transgenic male mice. Flow cytometry revealed that freshly isolated ADRCs expressed stem cell markers CD90 and Sca-1, and mesenchymal lineage marker. These cells exhibited multilineage differentiation into adipogenic, osteogenic, and chondrogenic lineages. Wild-type mice were subjected to 30 min of left ascending coronary ischemia and 24 h reperfusion. Freshly isolated ADRCs (105 cells) or vehicle (VEH), were administered intravenously through the tail at the time of reperfusion.Results: Compared to VEH, administration of ADRCs significantly reduced circulating troponin levels 24 h after I/R. Using quantitative real-time polymerase chain reaction analysis, the present study confirms that I/R-induced increase of factor X mRNA expression in the liver and was significantly inhibited by ADRCs compared to VEH. Administration of ADRCs significantly reduced the I/R-induced increase in serum levels of the proinflammatory cytokines tumor necrosis factor-alpha and interleukin-18 seen in mice receiving VEH.Conclusions: These results suggest that administration of ADRCs could have an important role in reducing myocardial injury and regulating the hepatic gene expression profile following I/R

A case of pulmonary tuberculosis accompanied with immune thrombocytopenic purpura

AbstractA 30-year-old Japanese woman with chest pain and nodules in the left upper lung field was diagnosed as having pulmonary tuberculosis by sputum examination. Purpura on her legs had lasted for 3 months and her platelet count was 1.9 × 104/mm3 on admission. She was also diagnosed as having immune thrombocytopenic purpura because of elevation of serum PA-IgG and proliferation of megakaryocytes in the bone marrow. Anti-tubercular therapy and steroid therapy were concurrently performed, resulted in recovery of the platelet count. Steroid therapy was gradually tapered off and then withdrawn, thereafter anti-tubercular therapy was finished. She has been relapse-free.Cases of pulmonary tuberculosis accompanied with immune thrombocytopenic purpura are rare. The pathogenesis in the present case was suggested to have occurred through an immunological mechanism

遺伝性乳癌卵巣癌症候群

Hereditary breast and ovarian cancer（HBOC）syndrome is an autosomal dominant genetic disease, which represents about ５% of all breast cancers. The pathogenic mutations in the BRCA １／２genes involved in DNA repair pathway are known to be associated with an increased risk of not only breast cancer and ovarian cancer but also prostate cancer, pancreatic cancer and male breast cancer. The risk reduction management is required for BRCA mutation-positive patients. The surveillance using breast magnetic resonance imaging（MRI）is recommended for early detection of breast cancer in HBOC patients. Furthermore, it has been reported that risk reducing salpingooophorectomy（RRSO）reduces mortality caused by breast cancer and ovarian cancer, and contralateral risk-reducing mastectomy（CRRM）improves the overall survival in postoperative breast cancer patients