Illusory position shift induced by plaid motion

AbstractIn the motion-induced position shift (MIPS), the position of a moving pattern tapered by a stationary envelope is perceived to shift in the direction of the motion. It was found that plaid motion also elicited a MIPS in the direction of global motion and this global MIPS could not be predicted by the average of the local MIPSs due to component motions. We also used a pseudo plaid pattern and again observed a global MIPS that could not be predicted by the local MIPSs due to the components of the pseudo plaid pattern. We suggest the possibility that the receptive-field positions of global motion detectors shift in the direction opposite to global motion, resulting in a positional displacement in activation via population coding

Assimilation-type and Contrast-type Bias of Motion Induced by the Surround in a Random-dot Display: Evidence for Center-Surround Antagonism

AbstractAs a mechanism to detect differential motion, we have proposed a model of “a motion contrast detector” that has a center-surround antagonistic receptive field with respect to the direction of motion. Supporting evidence has been obtained in the studies of induced motion, motion capture, and motion aftereffect. In order to obtain further evidence in a more strictly controlled situation, we examined the perceptual bias of motion in a center stimulus induced by another, surrounding motion. By using a stochastic random-dot display configured in a center-surround concentric fashion, we measured the % signal in the center stimulus that made the stimulus perceptually stationary in the presence of a moving surround. Measurements were done for various stimulus sizes and eccentricities. The amount of bias changed as a function of stimulus size and eccentricity. At several eccentricities. smaller stimulus sizes tended to yield assimilation-type biases, whereas larger sizes tended to yield contrast-type biases. However, a spatial scaling procedure revealed that the amount of bias was a simpler function of “scaled” stimulus size that was obtained by dividing the physical size by a scaling factor at each eccentricity. In the scaled profile, assimilation-type bias changed to contrast-type bias with increasing size, reached the peak of contrast-type bias at a certain size, and decreased slightly with further increasing size. Furthermore, a model of a difference of Gaussians, DOG, function well approximated the behavior of the profile. From these results, we concluded that the process specific to perceiving relative motion is mediated by a motion contrast detector, which is possibly located in area MT. Copyright © 1996 Elsevier Science Ltd

Evaluation of oral immunotherapy efficacy and safety by maintenance dose dependency: A multicenter randomized study

Background Generally, oral immunotherapy (OIT) aims for daily administration. Recently, the efficacy of treatment with OIT at a low dose has been reported. However, the optimal dose and the evaluation of dose-dependent OIT outcome have not been described. Methods A multicenter, parallel, open-labeled, prospective, non-placebo controlled, randomized study enrolled 101 Japanese patients for treatment with OIT. We hypothesized that target dose OIT would induce short-term unresponsiveness (StU) earlier than reduced dose OIT. StU was defined as no response to 6200 mg whole egg, 3400 mg milk, and 2600 mg wheat protein, as evaluated by oral food challenge after 2-week ingestion cessation. To compare the two doses of OIT efficacy, the maximum ingestion doses during the maintenance phase of OIT were divided into 100%-dose or 25%-dose groups against their target StU dose, respectively. A total of 51 patients were assigned to the 100%-dose group [hen's egg (HE) = 26, cow's milk (CM) = 13, wheat = 12] and 50 to the 25%-dose group (HE = 25, CM = 13, wheat = 12). Primary outcome was established by comparing StU at 1 year. Secondary outcome was StU at 2 years and established by comparing allergic symptoms and immunological changes. Results The year 1 StU rates (%) for the 100%- and 25%-dose groups were 26.9 vs. 20.0 (HE), 7.7 vs. 15.4 (CM), and 50.0 vs. 16.7 (wheat), respectively. The year 2 StU rates were 30.8 vs. 36.0 (HE), 7.7 vs. 23.1 (CM), and 58.3 vs. 58.3 (wheat), respectively. There were no statistically significant differences in StU between years 1 and 2. The total allergic symptom rate in the 25%-dose group was lower than that in the 100%-dose group for egg, milk, and wheat. Antigen-specific IgE levels for egg-white, milk, and wheat decreased at 12 months. Conclusions Reduced maintenance dose of egg OIT showed similar therapeutic efficacy to the target dose. However, we were not able to clearly demonstrate the efficacy, particularly for milk and wheat. Reducing the maintenance dose for eggs, milk, and wheat may effectively lower the symptoms associated with their consumption compared to the target OIT dose. Furthermore, aggressive reduction of the maintenance dose might be important for milk and wheat, compared to the 25%-dose OIT

Illusory jitter in a static stimulus surrounded by a synchronously flickering pattern

AbstractThe eyes are always moving even during fixation, making the retinal image move concomitantly. While these motions activate early visual stages, they are excluded from one’s perception. A striking illusion reported here renders them visible: a static pattern surrounded by a synchronously flickering pattern appears to move coherently in random directions. There was a positive correlation between the illusion and fixational eye movements. A simulation revealed that motion computation artificially creates a motion difference between center and surround, which is usually a cue to object motion but now a wrong cue to seeing eye movements of oneself on-line. Therefore, this novel illusion indicates that the visual system normally counteracts shaky visual inputs due to small eye movements by using retinal, as opposed to extraretinal, motion signals. As long as they comprise common image motions over space, they are interpreted as coming from a static outer world viewed through moving eyes. Such visual stability fails in the condition of artificial flicker, because common image motions due to eye movements are registered differently between flickering and non-flickering regions