Synthesis of Fluorine-18 Functionalized Nanoparticles for use as in vivo Molecular Imaging Agents

Nanoparticles containing fluorine-18 were prepared from block copolymers made by ring opening metathesis polymerization (ROMP). Using the fast initiating ruthenium metathesis catalyst (H_2IMes)(pyr)_2(Cl)_2Ru=CHPh, low polydispersity amphiphilic block copolymers were prepared from a cinnamoyl-containing hydrophobic norbornene monomer and a mesyl-terminated PEG-containing hydrophilic norbornene monomer. Self-assembly into micelles and subsequent cross-linking of the micelle cores by light-activated dimerization of the cinnamoyl groups yielded stable nanoparticles. Incorporation of fluorine-18 was achieved by nucleophilic displacement of the mesylates by the radioactive fluoride ion with 31% incorporation of radioactivity. The resulting positron-emitting nanoparticles are to be used as in vivo molecular imaging agents for use in tumor imaging

Quantifizierung der Bodenerosion durch Wind II. Teilvorhaben D: Flaechenhafte Modellierung mittels Fernerkundungsdaten Abschlussbericht

Up to now Germany has had no soil information system for quantifying soil erosion by wind or for planning and simulating protectional measures. Consequently, the aim of part-project D was to construct a special soil information system (BEWIS) with the areal data relevant to drifting for the model area of Cloppenburg (Varrelbush). Official data and data available over a large area were chiefly used (official surveys and NIBIS - Lower Saxony Soil Information System, Hannover) in order to prepare a subsequent extention of the modelling area. The following layers of information, some of which were further subdivided, were picked up in BEWIS: topography of the Germany base map 1:5000; digital elevation data (12.5 m raster); land use mapping 1991 by terrestrial survey and 1990 and 1991 by Landsat TM; original German Reich Soil Evaluation maps with data attained from test cavities (conversion of German Reich Soil Evaluation data into the soil-topological profile language and classification suggested by NIBIS); shelter belts etc. To determine and process the field length, an interactively appliable algorism was developed. (orig.)SIGLEAvailable from TIB Hannover: F95B481+a / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekBundesministerium fuer Forschung und Technologie (BMFT), Bonn (Germany)DEGerman