Chinonen en Chinonderivaten en hun invloed op micro-organismen

The second chapter of this thesis contains a survey of the most important antibiotics, which have been isolated up to the present. It will be seen that several of them are derivatives of quinones; a disadvantage is often their toxicity. We therefore tried to prepare other quinones in the hope of obtaining active compounds of lower toxicity. In this thesis are described a number of derivatives of p-benzo-quinone and p-toluquinone, which possess other groupings than the natural antibiotics of the quinone type viz. fumigatin (3-hydroxy-4-methoxy-2,5-toluquinone) and spinulosin (3, 6-dihydroxy-4-methoxy-2, 5-toluquinone) and which differ from the quinones prepared and tested by Oxford and his collaborators. ... Zie: Summary