The Use of Historical Data in Rule-Based Modelling for Scenarios to Improve Resilience within the Building Stock

Digital documentation has become integral to the preservation, analysis and communication of historical sites. New platforms are now being developed that involve complex 3D models and allow the analysis of spatial data. These include procedural modelling, a technique that enables the rapid development of ‘dynamic’ 3D environments, and generation of simulations for entire cities, resulting in low cost, high resolution 3D city models. Though procedural modelling has been used in the context of archaeology to ‘recreate’ cities at specific historic time points, the use of historical data in the development of rule-based procedural models for current cities has been little explored. Here, we test the extent to which construction age data, historical building regulations and architectural knowledge can be used in the generation of procedural rules, and the level of detail and potential impact that these models may have. Rather than creating an accurate representation of the city, we instead seek to simulate the way in which urban areas are likely to behave under certain conditions, in order to test what-if? planning scenarios. This allows us to explore more flexible ways of digitally ‘creating’ cities, past and present, and to gain insights into underlying ‘rules’ that govern their physical form

Redesigning Experience Consumption in Social VR Worlds : Decentralised Value Creation, Mobilisation, and Exchanges

Virtual reality technology based corporates have been developing user-driven open markets for over a decade. The most noticeable initial player was Linden Lab, the service provider of Second Life that launched its metaverse world in 2003. The main features of the service were collaborative VR creation interfaces, individual asset management systems, and the virtual currency named Linden dollar. By the main interaction/interface structure, the residents of Second Life could create a pixel world of their own imagination, reserve the value of digital experiences, and exchange the value of imagination, and experience individually or collectively. A decade of life experience of the virtual world gave us lessons of how people interact, communicate, and evaluate virtual goods and experiences. The recent HMD technology emerged the second round of consumer-based Social VR platform race that has become more immersive, realistic, and user- centred. Relating to the technological leap, recent appeals of Social VR platforms have drawn a great attention from public: Project Sansar of Linden Lab, High Fidelity, and AltSpaceVR to name but a few. The social VR platforms commonly installed co-presence, avatar embodiments, real-time collaborations, and communications over virtual spaces. Project Sansar has conceptually inherited the idea of “the world by residents” from Second Life, its virtual monetisation pilot system. Project Sansar launched creators preview in late 2016, and recruited 3D builders among Second Life business owners, who have potentiality of opening a new business in the Project Sansar platform. After over a year of creators preview operation, it tackled major technical issues of building worlds over a HMD enabled VR system, and key storefront features of a consumer based creation system. Apart from their day-to-day trouble shootings, it raised a couple of questions on critical facets of consumer based creation systems. First, the crowdsourced world building needs a common ground of the planning body. How do they build the common ground to give a form of imagination? Even though they run an extremely peripheral structure, ultimately they need an organizational steering that maintains rules, and actions. In short, how can residents share common architecture in a speculative nature? Eventually how does it transit to a planning, designing, building and consuming cycle? To address these research questions, we conducted a design game research that gathered data from design game participants who were second and third year students (N = 7) in an interaction design course. The participatory design methodology installed a group simulation for creativity that appeared the influences of immersion, and collaboration to a collective design quality. The research results highlighted the key elements of user-driven innovation in the virtual world and consumer based platforms. It gives insightful design guidelines for consumer based virtual reality services those are targeting decentralised monetary system developments in a practical perspective. Theoretically, it has a potential contribution to the complexity area that assimilates innovation models for multi-agents in technical sectors

Living with a Digital Twin: Operational management and engagement using IoT and Mixed Realities at UCL's Here East Campus on the Queen Elizabeth Olympic Park

The concept of Digital Twin is becoming increasingly popular with researchers and professionals in the AEC industries as a means of visualising, modelling and working with complex urban systems. This is achieved through the coupling of physical systems with comprehensive digital representations that automatically update to match the state of their physical counterpart. Using real-time data from IoT technologies and advanced 3D visualisation this research conducts a practical investigation into the process of creating and working with a Digital Twin of the new UCL Campus at Here East on the Queen Elizabeth Olympic Park

Data mash-ups and the future of mapping

The term 'mash-up' refers to websites that weave data from different sources into new Web services. The key to a successful Web service is to gather and use large datasets and harness the scale of the Internet through what is known as network effects. This means that data sources are just as important as the software that 'mashes' them, and one of the most profound pieces of data that a user has at any one time is his or her location. In the past this was a somewhat fuzzy concept, perhaps as vague as a verbal reference to being in a particular shop or café or an actual street address. Recent events, however, have changed this. In the 1990s, President Bill Clinton's policy decision to open up military GPS satellite technology for 'dual-use' (military and civilian) resulted in a whole new generation of location-aware devices. Around the same time, cartography and GIScience were also undergoing dramatic, Internet-induced changes. Traditional, resource intensive processes and established organizations, in both the public and private sectors, were being challenged by new, lightweight methods. The upshot has been that map making, geospatial analysis and related activities are undergoing a process of profound change. New players have entered established markets and disrupted routes to knowledge and, as we have already seen with Web 2.0, newly empowered amateurs are part of these processes. Volunteers are quite literally grabbing a GPS unit and hitting the streets of their local town to help create crowdsourced datasets that are uploaded to both open source and proprietary databases. The upshot is an evolving landscape which Tim O'Reilly, proponent of Web 2.0 and always ready with a handy moniker, has labelled Where 2.0. Others prefer the GeoWeb, Spatial Data Infrastructure, Location Infrastructure, or perhaps just location based services. Whatever one might call it, there are a number of reasons why its development should be of interest to those in higher and further education. Firstly, since a person's location is such a profound unit of information and of such value to, for example, the process of targeting advertising, there has been considerable investment in Web 2.0-style services that make use of it. Understanding these developments may provide useful insights for how other forms of data might be used. Secondly, education, particularly research, is beginning to realize the huge potential of the data mash-up concept. As Government, too, begins to get involved, it is likely that education will be expected to take advantage of, and indeed come to relish, the new opportunities for working with data. This TechWatch report describes the context for the changes that are taking place and explains why the education community needs to understand the issues around how to open up data, how to create mash-ups that do not compromise accuracy and quality and how to deal with issues such as privacy and working with commercial and non-profit third parties. It also shows how data mash-ups in education and research are part of an emerging, richer information environment with greater integration of mobile applications, sensor platforms, e-science, mixed reality, and semantic, machine-computable data and speculates on how this is likely to develop in the future

Boundaries of Semantic Distraction: Dominance and Lexicality Act at Retrieval

Three experiments investigated memory for semantic information with the goal of determining boundary conditions for the manifestation of semantic auditory distraction. Irrelevant speech disrupted the free recall of semantic category-exemplars to an equal degree regardless of whether the speech coincided with presentation or test phases of the task (Experiment 1) and occurred regardless of whether it comprised random words or coherent sentences (Experiment 2). The effects of background speech were greater when the irrelevant speech was semantically related to the to-be-remembered material, but only when the irrelevant words were high in output dominance (Experiment 3). The implications of these findings in relation to the processing of task material and the processing of background speech is discussed

Age-associated mitochondrial DNA mutations cause metabolic remodelling that contributes to accelerated intestinal tumorigenesis.

Oxidative phosphorylation (OXPHOS) defects caused by somatic mitochondrial DNA (mtDNA) mutations increase with age in human colorectal epithelium and are prevalent in colorectal tumours, but whether they actively contribute to tumorigenesis remains unknown. Here we demonstrate that mtDNA mutations causing OXPHOS defects are enriched during the human adenoma/carcinoma sequence, suggesting they may confer a metabolic advantage. To test this we deleted the tumour suppressor Apc in OXPHOS deficient intestinal stem cells in mice. The resulting tumours were larger than in control mice due to accelerated cell proliferation and reduced apoptosis. We show that both normal crypts and tumours undergo metabolic remodelling in response to OXPHOS deficiency by upregulating the de novo serine synthesis pathway (SSP). Moreover, normal human colonic crypts upregulate the SSP in response to OXPHOS deficiency prior to tumorigenesis. Our data show that age-associated OXPHOS deficiency causes metabolic remodelling that can functionally contribute to accelerated intestinal cancer development

The genomes of two key bumblebee species with primitive eusocial organization

Background: The shift from solitary to social behavior is one of the major evolutionary transitions. Primitively eusocial bumblebees are uniquely placed to illuminate the evolution of highly eusocial insect societies. Bumblebees are also invaluable natural and agricultural pollinators, and there is widespread concern over recent population declines in some species. High-quality genomic data will inform key aspects of bumblebee biology, including susceptibility to implicated population viability threats. Results: We report the high quality draft genome sequences of Bombus terrestris and Bombus impatiens, two ecologically dominant bumblebees and widely utilized study species. Comparing these new genomes to those of the highly eusocial honeybee Apis mellifera and other Hymenoptera, we identify deeply conserved similarities, as well as novelties key to the biology of these organisms. Some honeybee genome features thought to underpin advanced eusociality are also present in bumblebees, indicating an earlier evolution in the bee lineage. Xenobiotic detoxification and immune genes are similarly depauperate in bumblebees and honeybees, and multiple categories of genes linked to social organization, including development and behavior, show high conservation. Key differences identified include a bias in bumblebee chemoreception towards gustation from olfaction, and striking differences in microRNAs, potentially responsible for gene regulation underlying social and other traits. Conclusions: These two bumblebee genomes provide a foundation for post-genomic research on these key pollinators and insect societies. Overall, gene repertoires suggest that the route to advanced eusociality in bees was mediated by many small changes in many genes and processes, and not by notable expansion or depauperation

Low diversity Cryptococcus neoformans variety grubii multilocus sequence types from Thailand are consistent with an ancestral African origin.

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Experimental testing of reciprocal effects of nutrition and parasitism in wild black capuchin monkeys

Nutritional stress may predispose individuals to infection, which in turn can have further detrimental effects on physical condition, thus creating an opportunity for reciprocal effects between nutrition and parasitism. Little experimental investigation has been conducted on this "vicious circle" hypothesis in wild animals, especially under natural conditions. We evaluated the reciprocal effects of nutritional status and parasitism using an experimental approach in two groups of wild black capuchin monkeys (Sapajus nigritus). Across two consecutive winters, we collected faecal samples from identified capuchins to determine presence and load of gastrointestinal helminthes, and measured individual body mass as a proxy of physical condition. Food availability was manipulated by provisioning monkeys with bananas, and parasite burdens by applying anti-parasitic drugs to selected individuals. We found no effect of anti-parasitic drugs on physical condition, but parasite loads decreased in response to high levels of food availability. Our results represent the first experimental evidence that the nutritional status may drive parasite dynamics in a primate.Fil: Agostini, Ilaria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Biología Subtropical. Universidad Nacional de Misiones. Instituto de Biología Subtropical; Argentina. Centro de Investigaciones del Bosque Atlántico; ArgentinaFil: Vanderhoeven, Ezequiel Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; Argentina. Ministerio de Salud. Instituto Nacional de Medicina Tropical; Argentina. Centro de Investigaciones del Bosque Atlántico; ArgentinaFil: Di Bitetti, Mario Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Biología Subtropical. Universidad Nacional de Misiones. Instituto de Biología Subtropical; Argentina. Centro de Investigaciones del Bosque Atlántico; ArgentinaFil: Beldomenico, Pablo Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - CONICET - Santa Fe. Instituto de Ciencias Veterinarias del Litoral; Argentina. Laboratorio de Ecología de Enfermedades; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; Argentin

Growth-inhibitory effects of the chemopreventive agent indole-3-carbinol are increased in combination with the polyamine putrescine in the SW480 colon tumour cell line

BACKGROUND: Many tumours undergo disregulation of polyamine homeostasis and upregulation of ornithine decarboxylase (ODC) activity, which can promote carcinogenesis. In animal models of colon carcinogenesis, inhibition of ODC activity by difluoromethylornithine (DFMO) has been shown to reduce the number and size of colon adenomas and carcinomas. Indole-3-carbinol (I3C) has shown promising chemopreventive activity against a range of human tumour cell types, but little is known about the effect of this agent on colon cell lines. Here, we investigated whether inhibition of ODC by I3C could contribute to a chemopreventive effect in colon cell lines. METHODS: Cell cycle progression and induction of apoptosis were assessed by flow cytometry. Ornithine decarboxylase activity was determined by liberation of CO(2 )from (14)C-labelled substrate, and polyamine levels were measured by HPLC. RESULTS: I3C inhibited proliferation of the human colon tumour cell lines HT29 and SW480, and of the normal tissue-derived HCEC line, and at higher concentrations induced apoptosis in SW480 cells. The agent also caused a decrease in ODC activity in a dose-dependent manner. While administration of exogenous putrescine reversed the growth-inhibitory effect of DFMO, it did not reverse the growth-inhibition following an I3C treatment, and in the case of the SW480 cell line, the effect was actually enhanced. In this cell line, combination treatment caused a slight increase in the proportion of cells in the G(2)/M phase of the cell cycle, and increased the proportion of cells undergoing necrosis, but did not predispose cells to apoptosis. Indole-3-carbinol also caused an increase in intracellular spermine levels, which was not modulated by putrescine co-administration. CONCLUSION: While indole-3-carbinol decreased ornithine decarboxylase activity in the colon cell lines, it appears unlikely that this constitutes a major mechanism by which the agent exerts its antiproliferative effect, although accumulation of spermine may cause cytotoxicity and contribute to cell death. The precise mechanism by which putrescine enhances the growth inhibitory effect of the agent remains to be elucidated, but does result in cells undergoing necrosis, possibly following accumulation in the G(2)/M phase of the cell cycle