Parental choice of preschool in Taiwan

This research investigates parental choice in an active preschool education market in Taiwan. Most research into parental choice of school has been conducted in quasi-markets; markets that are highly regulated by government policy. The Taiwanese preschool market could be said to be a true market, operating through supply and demand and regulated by price. How parents operate in such markets and how their choice influences what is offered, is less explored. The research consisted of following eighteen parents through the choice process. Data collection methods involved diaries completed before the child started preschool and two in-depth interviews; one at the beginning of the school year and one nine months later. The parents who supplied the information came from different educational backgrounds, social status and family structures. For most it was their first experience of choosing an educational setting for their children. Using a rational choice theoretical framework the thesis argues that there was certain rationality in the parents’ process of choice but balancing the benefits and costs of preschool education was embedded in a wider family context. In addition, the findings show that whilst the parents were initially concerned about the more structural aspects of quality, their on-going engagement with the preschool provision enabled them to have a deeper understanding of process issues. However, there were other criteria that the parents used which would suggest that they were defining quality in a way that may be more influenced by Taiwanese life and culture. One implication is that the quality of preschool provision is not likely to improve if it is purely dependent on preschools wishing to meet the parents’expectations. However, neither will it improve if the contextual conditions are ignored. The implications for Taiwanese government preschool policy are discussed.EThOS - Electronic Theses Online ServiceGBUnited Kingdo

Lessons Learned from PEARL CubeSats Operation

PEARL (Propagation Experiment using kurz-Above-band radio in Low earth orbit) CubeSats consists of two 6U XL CubeSats, named as PEARL-1C and PEARL-1H, integrated by National Central University (NCU) and Hon Hai Precision Industry Co., Ltd. (Foxconn) for educational training/scientific research was launched into a sun-synchronous orbit at 520 km altitude around 1030 local time sector by SpaceX Transporter-9 rideshare mission from Vandenburg Space Force Base on 11 November 2023. On PEARL-1C, two payloads are installed: a Ka-band communication payload (KCP) is developed by Rapidtek Technologies for broadband communication experiment and a Compact Ionospheric Probe (CIP) is an all-in-one in-situ ion sensor developed by NCU to measure global ionospheric ion concentration, velocity, and temperature. On PEARL-1H, a Communication PayLoad (CPL), which is developed by Tron Future to conduct broadband communication experiment with the beam-steering phase array antenna, is installed. Although both satellites are aimed at communication experiments, their system designs and configurations are still different. The CIP on PEARL-1C needs to face the forward direction to collect plasma. The attitude control is very important. There are two power distribution modules (PDM0 and two battery packs (BP) on PEARL-1H. Except for the battery raw power, all power sources providing the same voltage are shared and each BP is managed individually through each PDM. It is heavier and requires attention to mode changing. Therefore, the performances of on-orbit operation for these two CubeSat are also different and we need to make different operating instructions in response to different conditions. In this research, we will discuss the perfomances of PEARL CubeSats on the ground and on orbit, and presented with some experimental results

Inferring nonneutral evolution from contrasting patterns of polymorphisms and divergences in different protein coding regions of enterovirus 71 circulating in Taiwan during 1998-2003

<p>Abstract</p> <p>Background</p> <p>Enterovirus (EV) 71 is one of the common causative agents for hand, foot, and, mouth disease (HFMD). In recent years, the virus caused several outbreaks with high numbers of deaths and severe neurological complications. Despite the importance of these epidemics, several aspects of the evolutionary and epidemiological dynamics, including viral nucleotide variations within and between different outbreaks, rates of change in immune-related structural regions vs. non-structural regions, and forces driving the evolution of EV71, are still not clear.</p> <p>Results</p> <p>We sequenced four genomic segments, i.e., the 5' untranslated region (UTR), VP1, 2A, and 3C, of 395 EV71 viral strains collected from 1998 to 2003 in Taiwan. The phylogenies derived from different genomic segments revealed different relationships, indicating frequent sequence recombinations as previously noted. In addition to simple recombinations, exchanges of the P1 domain between different species/genotypes of human enterovirus species (HEV)-A were repeatedly observed. Contrasting patterns of polymorphisms and divergences were found between structural (VP1) and non-structural segments (2A and 3C), i.e., the former was less polymorphic within an outbreak but more divergent between different HEV-A species than the latter two. Our computer simulation demonstrated a significant excess of amino acid replacements in the VP1 region implying its possible role in adaptive evolution. Between different epidemic seasons, we observed high viral diversity in the epidemic peaks followed by severe reductions in diversity. Viruses sampled in successive epidemic seasons were not sister to each other, indicating that the annual outbreaks of EV71 were due to genetically distinct lineages.</p> <p>Conclusions</p> <p>Based on observations of accelerated amino acid changes and frequent exchanges of the P1 domain, we propose that positive selection and subsequent frequent domain shuffling are two important mechanisms for generating new genotypes of HEV-A. Our viral dynamics analysis suggested that the importation of EV71 from surrounding areas likely contributes to local EV71 outbreaks.</p

Immune reconstitution inflammatory syndrome of Kaposi’s sarcoma in an HIV-infected patient

We present a case of Kaposi’s sarcoma-related immune reconstitution inflammatory syndrome in an HIV-infected patient who developed fever, worsening pulmonary infiltrates with respiratory distress, and progression of skin tumors at the popliteal region and thigh that resulted in limitation on movement of the right knee joint at 3.5 months following a significant increase of CD4 count after combination antiretroviral therapy

Serotype Competence and Penicillin Resistance in Streptococcus pneumoniae

Enhanced molecular surveillance of virulent clones with higher competence can detect serotype switching

Influenza Pandemics: Past, Present and Future

Influenza A virus is well known for its capability for genetic changes either through antigen drift or antigen shift. Antigen shift is derived from reassortment of gene segments between viruses, and may result in an antigenically novel virus that is capable of causing a worldwide pandemic. As we trace backwards through the history of influenza pandemics, a repeating pattern can be observed, namely, a limited wave in the first year followed by global spread in the following year. In the 20th century alone, there were three overwhelming pandemics, in 1918, 1957 and 1968, caused by H1N1 (Spanish flu), H2N2 (Asian flu) and H3N2 (Hong Kong flu), respectively. In 1957 and 1968, excess mortality was noted in infants, the elderly and persons with chronic diseases, similar to what occurred during interpandemic periods. In 1918, there was one distinct peak of excess death in young adults aged between 20 and 40 years old; leukopenia and hemorrhage were prominent features. Acute pulmonary edema and hemorrhagic pneumonia contributed to rapidly lethal outcome in young adults. Autopsies disclosed multiple-organ involvement, including pericarditis, myocarditis, hepatitis and splenomegaly. These findings are, in part, consistent with clinical manifestations of human infection with avian influenza A H5N1 virus, in which reactive hemophagocytic syndrome was a characteristic pathologic finding that accounted for pancytopenia, abnormal liver function and multiple organ failure. All the elements of an impending pandemic are in place. Unless effective measures are implemented, we will likely observe a pandemic in the coming seasons. Host immune response plays a crucial role in disease caused by newly emerged influenza virus, such as the 1918 pandemic strain and the recent avian H5N1 strain. Sustained activation of lymphocytes and macrophages after infection results in massive cytokine response, thus leading to severe systemic inflammation. Further investigations into how the virus interacts with the host's immune system will be helpful in guiding future therapeutic strategies in facing influenza pandemics

Prophage Excision in Streptococcus pneumoniae Serotype 19A ST320 Promote Colonization: Insight Into Its Evolution From the Ancestral Clone Taiwan 19F-14 (ST236)

Streptococcus pneumoniae 19A ST320, a multidrug-resistant strain with high disease severity that notoriously spread before the use of expanded pneumococcal conjugate vaccines, was derived from a capsular switching event between an international strain Taiwan 19F-14 (ST236) and a serotype 19A strain. However, the molecular mechanisms underlying the adaptive evolution of 19F ST236 to 19A ST320 are unknown. In this study, we compared 19A ST320 to its ancestral clone, 19F ST236, in terms of adherence to respiratory epithelial cells, whole transcriptome, and ability to colonize a young mouse model. Serotype 19A ST320 showed five-fold higher adherence to A549 cells than serotype 19F ST236. High-throughput mRNA sequencing identified a prophage region located between dnaN and ychF in both strains; however, the genes in this region were expressed at significantly higher levels in 19A ST320 than in 19F ST236. Analysis by polymerase chain reaction (PCR) showed that the prophage is able to spontaneously excise from the chromosome and form a circular episome in 19A ST320, but not in 19F ST236. Deletion of the integrase in the prophage of 19A ST320 decreased spontaneous excision and cell adherence, which were restored by complementation. Competition experiments in mice showed that the integrase mutant was six-fold less competitive than the 19A ST320 parent (competitive index [CI]: 0.16; p = 0.02). The 19A ST320 prophage-deleted strain did not change cell adherence capacity, whereas prophage integration strains (integrase mutant and 19F) had decreased expression of the down-stream ychF gene compared to that of 19A ST320. Further deletion of ychF significantly reduced cell adherence. In conclusions, these findings suggest that spontaneous prophage induction confers a competitive advantage to virulent pneumococci

Arrhythmia Evaluation in Wearable ECG Devices

This study evaluates four databases from PhysioNet: The American Heart Association database (AHADB), Creighton University Ventricular Tachyarrhythmia database (CUDB), MIT-BIH Arrhythmia database (MITDB), and MIT-BIH Noise Stress Test database (NSTDB). The ANSI/AAMI EC57:2012 is used for the evaluation of the algorithms for the supraventricular ectopic beat (SVEB), ventricular ectopic beat (VEB), atrial fibrillation (AF), and ventricular fibrillation (VF) via the evaluation of the sensitivity, positive predictivity and false positive rate. Sample entropy, fast Fourier transform (FFT), and multilayer perceptron neural network with backpropagation training algorithm are selected for the integrated detection algorithms. For this study, the result for SVEB has some improvements compared to a previous study that also utilized ANSI/AAMI EC57. In further, VEB sensitivity and positive predictivity gross evaluations have greater than 80%, except for the positive predictivity of the NSTDB database. For AF gross evaluation of MITDB database, the results show very good classification, excluding the episode sensitivity. In advanced, for VF gross evaluation, the episode sensitivity and positive predictivity for the AHADB, MITDB, and CUDB, have greater than 80%, except for MITDB episode positive predictivity, which is 75%. The achieved results show that the proposed integrated SVEB, VEB, AF, and VF detection algorithm has an accurate classification according to ANSI/AAMI EC57:2012. In conclusion, the proposed integrated detection algorithm can achieve good accuracy in comparison with other previous studies. Furthermore, more advanced algorithms and hardware devices should be performed in future for arrhythmia detection and evaluation.Cal-Comp Electronics & Communications Co., Ltd.; Kinpo Electronics, Inc. New Taipei City, Taiwan. Innovation Center for Big Data and Digital Convergence; Yuan Ze University, Taiwan