Differences Lead to Differences: Diversity and Income Inequality Across Countries

This paper will test the relationship between income inequality and ethnic heterogeneity. Although previous research has used ethno-linguistic fractionalization as a control variable in inequality regressions, no research has focused primarily on an alternative measure of heterogeneity – polarization. Using Gini coefficients from the from the World Income Inequality Database and polarization data from Montalvo and Reynal-Querol (2005b), a pooled OLS regression is run using data from 58 countries with 205 total observations. The results of these regressions suggest that ethnic polarization does have a positive effect on income inequality, even controlling for country characteristics and allowing for regional differences

A live RSV vaccine with engineered thermostability is immunogenic in cotton rats despite high attenuation

Respiratory syncytial virus (RSV) is a leading cause of infant hospitalization and there remains no pediatric vaccine. RSV live-attenuated vaccines (LAVs) have a history of safe testing in infants; however, achieving an effective balance of attenuation and immunogenicity has proven challenging. Here we seek to engineer an RSV LAV with enhanced immunogenicity. Genetic mapping identifies strain line 19 fusion (F) protein residues that correlate with pre-fusion antigen maintenance by ELISA and thermal stability of infectivity in live RSV. We generate a LAV candidate named OE4 which expresses line 19F and is attenuated by codon-deoptimization of non-structural (NS1 and NS2) genes, deletion of the small hydrophobic (SH) gene, codon-deoptimization of the attachment (G) gene and ablation of the secreted form of G. OE4 (RSV-A2-dNS1-dNS2-ΔSH-dGm-Gsnull-line19F) exhibits elevated pre-fusion antigen levels, thermal stability, immunogenicity, and efficacy despite heavy attenuation in the upper and lower airways of cotton rats

EGFR interacts with the fusion protein of respiratory syncytial virus strain 2-20 and mediates infection and mucin expression.

Respiratory syncytial virus (RSV) is the major cause of viral lower respiratory tract illness in children. In contrast to the RSV prototypic strain A2, clinical isolate RSV 2-20 induces airway mucin expression in mice, a clinically relevant phenotype dependent on the fusion (F) protein of the RSV strain. Epidermal growth factor receptor (EGFR) plays a role in airway mucin expression in other systems; therefore, we hypothesized that the RSV 2-20 F protein stimulates EGFR signaling. Infection of cells with chimeric strains RSV A2-2-20F and A2-2-20GF or over-expression of 2-20 F protein resulted in greater phosphorylation of EGFR than infection with RSV A2 or over-expression of A2 F, respectively. Chemical inhibition of EGFR signaling or knockdown of EGFR resulted in diminished infectivity of RSV A2-2-20F but not RSV A2. Over-expression of EGFR enhanced the fusion activity of 2-20 F protein in trans. EGFR co-immunoprecipitated most efficiently with RSV F proteins derived from "mucogenic" strains. RSV 2-20 F and EGFR co-localized in H292 cells, and A2-2-20GF-induced MUC5AC expression was ablated by EGFR inhibitors in these cells. Treatment of BALB/c mice with the EGFR inhibitor erlotinib significantly reduced the amount of RSV A2-2-20F-induced airway mucin expression. Our results demonstrate that RSV F interacts with EGFR in a strain-specific manner, EGFR is a co-factor for infection, and EGFR plays a role in RSV-induced mucin expression, suggesting EGFR is a potential target for RSV disease

City of Hitchcock Comprehensive Plan 2020-2040

Hitchcock is a small town located in Galveston County (Figure 1.1), nestled up on the Texas Gulf Coast. It lies about 40 miles south-east of Houston. The boundaries of the city encloses an area of land of 60.46 sq. miles, an area of water of 31.64 sq. miles at an elevation just 16 feet above sea level. Hitchcock has more undeveloped land (~90% of total area) than the county combined. Its strategic location gives it a driving force of opportunities in the Houston-Galveston Region.The guiding principles for this planning process were Hitchcock’s vision statement and its corresponding goals, which were crafted by the task force. The goals focus on factors of growth and development including public participation, development considerations, transportation, community facilities, economic development, parks, and housing and social vulnerabilityTexas Target Communitie

Replication Data for: A Low-Cost Information Nudge Increases Citizenship Application Rates Among Low-Income Immigrants

These files contain the data and code files for replicating the study in the paper:"A Low-Cost Information Nudge Increases Citizenship Application Rates Among Low-Income Immigrants". The folder contains a README.txt file

Ethnic and Religious Diversity and Income Inequality

Using cross-country data, we explore the relationship between ethnic and religious diversity and income inequality. For 58 countries spanning a 10-year period, we find a positive relationship between ethnic and religious polarization and income inequality and an inverse U-shaped relationship between ethnic and religious fractionalization and income inequality. According to our estimations (i) going from an ethnic (religious) polarization index of 0, to an ethnic (religious) polarization index of 1 would increase the Gini coefficient by almost 6 (respectively, 3) percentage points; and (ii) the Gini coefficient would be maximized when the ethnic (religious) fractionalization index is equal to 0.44 (respectively, 0.34). Implications are considered.

Association between Parents' Nativity Status and Influenza Vaccination Rates among Children

Previous research has documented lower vaccination rates among ethnic and racial minorities as well as foreign-born people, thus raising concerns about health inequities during pandemics. We analyzed influenza vaccination rates among children with US-born parents and those with at least one immigrant parent. We found that children with immigrant parents have higher odds of receiving the influenza vaccination even after controlling for socio-demographic characteristics

Replication for: Standardizing the Fee Waiver Application Increased Naturalization Rates of Low-Income Immigrants

Replication files for "Standardizing the Fee Waiver Application Increased Naturalization Rates of Low-Income Immigrants" PNAS