Clinical outcomes after maxillofacial reconstruction using the free fibular flap in children: A systematic review and meta-analysis

Background and aim: In the present study, an attempt has been made to investigate the complications and consequences of using the free fibular flap after maxillofacial reconstruction in children. Therefore, the present study was conducted with the aim of evaluating clinical outcomes after maxillofacial reconstruction using the free fibular flap in children. Method: Present study is a systematic review and meta-analysis based on PRISMA 2020 Checklist. Databases of PubMed, Scopus, Web of Science, EBSCO, ISI Web of Knowledge, and Embase were searched for systematic literature until 30 November 2022.  A 95% confidence interval for effect size with the random effect model and REML method were calculated. Meta-analysis was performed using Stata/MP v.17 software. Result: In the initial review, duplicate studies were eliminated and abstracts of 428 studies were reviewed, the full text of 155 studies was reviewed by two authors, and finally, 15 studies were selected. major and minor complication rate was 7% (ES, 7 95% CI 6%, 14%) and 23% (ES, 23% 95% CI 3%, 42%). Based on the present meta-analysis, the use of a free fibular flap is a reliable and appropriate option in reconstructing the jaw and face of children with few major complications and minor complications

Evaluate different nanoparticles into dental restorative materials: A systematic review and meta-analysis

Background and aim: The purpose of this study was to evaluate different nanoparticles in dental restorative materials. Method: Databases of PubMed, Scopus, Web of Science, EBSCO, ISI Web of Knowledge, and Embase were searched for systematic literature between 2012 to July 2022.  Data analysis was performed using STATA/MP V17 software. 95% confidence interval for mean differences or Hedges' g (a measure of effect size) with fixed effect model and Inverse-variance method were calculated. Result: In the initial review, duplicate studies were eliminated and abstracts of 151 studies were reviewed, the full text of 42 studies was reviewed by two authors, and finally, 11 studies were selected. Hedges' g of changes to the bacterial activity of dental restorative materials for silver nanoparticles was –1.90 (Hedges' g -1.90 95% CI -2.52, -1.28), for calcium phosphate nanoparticles, was –0.64 (Hedges' g -0.64 95% CI -2.03, 0.94), for CaP/Ag nanoparticles was –0.44 (Hedges' g -0.44 95% CI –1.83, 0.94) and Hedges' g of changes to the bacterial activity of dental restorative materials for Titanium dioxide nanoparticles was –2.41 (Hedges' g -2.41 95% CI –3.11, -1.72).&nbsp

Evaluation of cytotoxicity and antibacterial activity of different pulp capping liners

AbstractThis study compares the cytotoxicity and antibacterial activity of five pulp capping liners. This in vitro study was conducted on Fuji II LC glass ionomer, Dycal, Calcimol LC, TheraCal LC, and ACTIVA BioACTIVE. For cytotoxicity, the (MTT) methyl thiazolyl tetrazolium assay was performed on 3 samples from each group of human dental pulp cells (HDPSCs) after 24 h of incubation. The direct contact test (DCT) for antibacterial activity, 6 samples (3 for each material, and 3 for negative control), from each liner were made to evaluate Streptococcus mutans (S. mutans), Lactobacillus casei (L. casei), and Lactobacillus acidophilus (L. acidophilus). Data were analyzed by one-way ANOVA and Tukey’s post-hoc test (alpha = 0.05). Data analysis showed that the cytotoxicity of the materials was significantly different (p < 0.001). Fuji II LC and ACTIVA BioACTIVE showed strong cytotoxicity, TheraCal LC moderate cytotoxicity, and Dycal and Calcimol LC slight cytotoxicity. The analysis also revealed a significant difference among the materials regarding antibacterial activity (p < 0.001). Tukey’s test showed that the mean percentage of reduction in colony count was significant for all liners compared with the positive control (p < 0.001). The mean percentage of reduction in colony count for Dycal was significantly greater than that of Fuji II LC (p = 0.014), Calcimol LC (p = 0.003), and TheraCal LC (p = 0.001). ACTIVA BioACTIVE did not significantly differ from the other materials as regards antibacterial activity. Dycal showed significantly higher antibacterial activity than the other materials