Review of the effectiveness of current community ownership mechanisms and of options for supporting the expansion of community ownership in Scotland

This report presents the findings of research commissioned by the Scottish Land Commission to review the effectiveness of community ownership mechanisms and options for simplifying or improving these mechanisms to enable and support the expansion of community ownership in Scotland. This included reviewing processes relating to negotiated sales or transfers of land and/or assets to communities, as well as legislative mechanisms including the Community Right to Buy (CRtB), Crofting Community Right to Buy, the Transfer of Crofting Estates (Scotland) Act 1997 and Asset Transfer measures under the Community Empowerment (Scotland) Act 2015

In danger of co-option: Examining how austerity and central control shape community woodlands in Scotland

Community ownership and management of land has gained prominence in environmental policy discussions, especially within land restoration debates. Within Scotland, community land ownership is promoted as a means to give communities greater say over land use decisions, receive a greater share of the benefits from land, and help deliver a just transition to the government of Scotland’s net-zero targets. These goals are supported by legal mechanisms that enable appropriately constituted community bodies to buy or lease erstwhile private and public assets to deliver a wide range of social, environmental, and economic objectives. Drawing on interviews and secondary data, we inductively explore the transfer of public forests to communities in Scotland, examining the context of these transfers, the challenges in acquiring and managing forests, and broader implications of asset transfers for community empowerment. We find that community woodland groups operate in a political context shaped by public sector austerity, increasingly stepping in to provide services that local governments have withdrawn from. Our distinct contribution is to demonstrate the ways in which formalization and standardization can have a centralizing effect on place-based initiatives. Both these trends, we argue, can lead to uneven outcomes for community groups. As communities increasingly become part of global environmental agendas, we argue for a critical political geography of’community empowerment’, one that pays attention to the relationship between political processes and uneven outcomes

Clinical trial in healthy malaria-naïve adults to evaluate the safety, tolerability, immunogenicity and efficacy of MuStDO5, a five-gene, sporozoite/hepatic stage Plasmodium falciparum DNA vaccine combined with escalating dose human GM-CSF DNA

When introduced in the 1990s, immunization with DNA plasmids was considered potentially revolutionary for vaccine development, particularly for vaccines intended to induce protective CD8 T cell responses against multiple antigens. We conducted, in 1997−1998, the first clinical trial in healthy humans of a DNA vaccine, a single plasmid encoding Plasmodium falciparum circumsporozoite protein (PfCSP), as an initial step toward developing a multi-antigen malaria vaccine targeting the liver stages of the parasite. As the next step, we conducted in 2000–2001 a clinical trial of a five-plasmid mixture called MuStDO5 encoding pre-erythrocytic antigens PfCSP, PfSSP2/TRAP, PfEXP1, PfLSA1 and PfLSA3. Thirty-two, malaria-naïve, adult volunteers were enrolled sequentially into four cohorts receiving a mixture of 500 μg of each plasmid plus escalating doses (0, 20, 100 or 500 μg) of a sixth plasmid encoding human granulocyte macrophage-colony stimulating factor (hGM-CSF). Three doses of each formulation were administered intramuscularly by needle-less jet injection at 0, 4 and 8 weeks, and each cohort had controlled human malaria infection administered by five mosquito bites 18 d later. The vaccine was safe and well-tolerated, inducing moderate antigen-specific, MHC-restricted T cell interferon-γ responses but no antibodies. Although no volunteers were protected, T cell responses were boosted post malaria challenge. This trial demonstrated the MuStDO5 DNA and hGM-CSF plasmids to be safe and modestly immunogenic for T cell responses. It also laid the foundation for priming with DNA plasmids and boosting with recombinant viruses, an approach known for nearly 15 y to enhance the immunogenicity and protective efficacy of DNA vaccines