Clinical evaluation of serum CA125 levels in gynecological disease patients

Since Bast et. al. reported that patients with ovarian carcinoma had elevated levels of CA125 in serum, the attention has been paid to CA125 in serum as a tumor maker. Serum CA125 levels in 88 patients with gynecological disease were measured. Among 15 patients with malignant ovarian tumor, CA125 values were above 35 U/ml in 80% , and above 65 U/ml in 73% , of serum samples assayed. By increasing the values of CA125 considered normal from 35 to 65 U/ml, the positive rate of benign ovarian tumor and carcinoma of the uterus was markedly reduced. Therefore, it was more efficient as a screening test for gynecological disease that the value of CA125 considered abnormal be above 65 U/ml. Serum CA125 levels were correlated with efficacy of therapy and the clinical course

Clinical evaluation of serum ferritin levels in primary lung cancer patients with radiation therapy Comparing with serum CEA levels

Serum ferritin and serum carcinogenic embryonic antigen (CEA) levels in 153 patients (male: 112, female: 41) with primary lung cancer were simultaneously measured and compared with the histological type, clinical stage and clinical course. No correlation between serum ferritin and CEA levels was found. A higher percentage of positive test results for both serum ferritin and CEA was associated with advanced stages and metastasis in other organs. From the point of view of histological classification, high ferritin levels were mainly found in the patients with small-cell types of cancer. In contrast, high CEA levels were found in patients with adenocarcinoma. Therefore, the measurement of serum ferritin was not efficient as a screening test for lung cancer. Serum ferritin levels were, however, correlated with the efficacy of therapy and the clinical course

Comparison of CT image of basal ganglia calcification with clinical symptoms

We investigated the relationship between the frequency of basal ganglia calcification appearing in CT scans and clinical symptoms in 3,599 patients. Basal ganglia were calcified in eleven patients (0.3%), of whom seven had calcification of the bilateral G. Pallidus, but no clinical symptoms. A relationship between calcification and clinical symptoms was shown in two patients under ten years old, a three-year-old with young brain atrophy and a six-year-old with a gonadotropin-producing brain tumor. Especially in patients over forty years old, a direct relationship between G.P. calcification and clinical symptoms was not shown, and calcification was considered to be pyhsilogical

Early clinical experience with NMR-CT

We have used an NMR-CT scanner clinically since August 1 1984. We report herein the operating pulse sepuences, and present 5 cases of 226 cases that we have examined. From our clinical experience during the past four months, we describe the advantages and disadvantages of NMR-CT. The advantages are that: 1) it is possible to recognize blood vessels without contrast materials and to evaluate the blood flow 2) there are neither bone nor air artifacts, and 3) it is possible to get the tomogram in any direction. The disadvantages are that: 1) the examination time is very long, 2) there are artifacts from ferromagnetic substances placed in the body, 3) when palse sequence is changed, images are different from each other, and 4) because of respiratory motion artifacts, the images of the chest and abdomen are inferior to those of other parts of the body