Diisopropyl(N,N,N \u27,N \u27-tetramethylethylenediamine)zinc(II), the first crystal structure of a diisopropylzinc complex

Although diisopropylzinc has attracted considerable interest as a useful organometallic reagent over the past ten years, diisopropylzinc complexes are still absent in the present version of the Cambridge Structural Database. In the title compound, a tmeda (tmeda is N, N, N\u27, N\u27-tetramethylethylenediamine) adduct, [Zn(C3H7)(2)(C6H16N2)], the Zn II atom, which lies on a crystallographic twofold rotation axis, is in a distorted tetrahedral geometry. The molecules are held together by dispersion forces, without any contacts within the sum of the van der Waals radii

The chaperone co-inducer BGP-15 alleviates ventilation-induced diaphragm dysfunction

Ventilation-induced diaphragm dysfunction (VIDD) is a marked decline in diaphragm function in response to mechanical ventilation, which has negative consequences for individual patients' quality of life and for the health care system, but specific treatment strategies are still lacking. We used an experimental intensive care unit (ICU) model, allowing time-resolved studies of diaphragm structure and function in response to long-term mechanical ventilation and the effects of a pharmacological intervention (the chaperone co-inducer BGP-15). The marked loss of diaphragm muscle fiber function in response to mechanical ventilation was caused by posttranslational modifications (PTMs) of myosin. In a rat model, 10 days of BGP-15 treatment greatly improved diaphragm muscle fiber function (by about 100%), although it did not reverse diaphragm atrophy. The treatment also provided protection from myosin PTMs associated with HSP72 induction and PARP-1 inhibition, resulting in improvement of mitochondrial function and content. Thus, BGP-15 may offer an intervention strategy for reducing VIDD in mechanically ventilated ICU patients