What is the molecular pathology that underlies hippocampal memory decline?

Peer reviewedPreprin

Economic Incentives Versus Command and Control: What's the Best Approach for Solving Environmental Problems?

Now, decades after the first environmental laws were passed in this country, policymakers face many choices when seeking to solve environmental problems. Will taxing polluters for their discharges be more effective than fining them for not meeting certain emissions standards? Will a regulatory agency find it less costly to enforce a ban or oversee a system of tradable permits? Which strategy will reduce a pollutant the quickest? Clearly, there are no "one-size-fits-all" answers. Many factors enter into the decision to favor either policies that lean more toward economic incentives (EI) and toward direct regulation, commonly referred to as command-and-control (CAC) policy. Underlying determinants include a country's governmental and regulatory infrastructure, along with the nature of the environmental problem itself. Even with these contextual factors to consider, we thought it would be useful to compare EI and CAC policies and their outcomes in a real-world setting. To do this, we looked at six environmental problems that the United States and at least one European country dealt with differently (see box on page 14.) For each problem, one approach was more of an EI measure, while the other relied more on CAC. For example, to reduce point-source industrial water pollution, the Netherlands implemented a system of fees for organic pollutants (EI), while the United States established a system of guidelines and permits (CAC). It turned out, in fact, that most policies had at least some elements of both approaches, but we categorized them as EI or CAC based on their dominant features. We then asked researchers who had previously studied these policies on either side of the Atlantic to update or prepare new case studies. We analyzed the 12 case studies (two for each of the six environmental problems) against a list of hypotheses frequently made for or against EI and CAC, such as which instrument is more effective or imposes less administrative burden

(E,E)-N1,N2-Bis(2,6-di­fluoro­benzyl­idene)ethane-1,2-di­amine.

The asymmetric unit of the title compound, C16H12F4N2, comprises half of the potentially bidentate Schiff base ligand, with an inversion centre located at the mid-point of the central C—C bond. The crystal packing is stabilized by inter­molecular C—H⋯N and π–π inter­actions [centroid–centroid distance = 3.6793 (12) Å and inter­planar spacing = 3.4999 (7) Å]

Calibrating and Stabilizing Spectropolarimeters with Charge Shuffling and Daytime Sky Measurements

Well-calibrated spectropolarimetry studies at resolutions of $R>$10,000 with signal-to-noise ratios (SNRs) better than 0.01\% across individual line profiles, are becoming common with larger aperture telescopes. Spectropolarimetric studies require high SNR observations and are often limited by instrument systematic errors. As an example, fiber-fed spectropolarimeters combined with advanced line-combination algorithms can reach statistical error limits of 0.001\% in measurements of spectral line profiles referenced to the continuum. Calibration of such observations is often required both for cross-talk and for continuum polarization. This is not straightforward since telescope cross-talk errors are rarely less than $\sim$1\%. In solar instruments like the Daniel K. Inouye Solar Telescope (DKIST), much more stringent calibration is required and the telescope optical design contains substantial intrinsic polarization artifacts. This paper describes some generally useful techniques we have applied to the HiVIS spectropolarimeter at the 3.7m AEOS telescope on Haleakala. HiVIS now yields accurate polarized spectral line profiles that are shot-noise limited to 0.01\% SNR levels at our full spectral resolution of 10,000 at spectral sampling of $\sim$100,000. We show line profiles with absolute spectropolarimetric calibration for cross-talk and continuum polarization in a system with polarization cross-talk levels of essentially 100\%. In these data the continuum polarization can be recovered to one percent accuracy because of synchronized charge-shuffling model now working with our CCD detector. These techniques can be applied to other spectropolarimeters on other telescopes for both night and day-time applications such as DKIST, TMT and ELT which have folded non-axially symmetric foci.Comment: Accepted to A&

Experimental evaluation of blockage ratio and plenum evacuation system flow effects on pressure distribution for bodies of revolution in 0.1 scale model test section of NASA Lewis Research Center's proposed altitude wind tunnel

An experimental investigation was conducted in the slotted test section of the 0.1-scale model of the proposed Altitude Wind Tunnel to evaluate wall interference effects at tunnel Mach numbers from 0.70 to 0.95 on bodies of revolution with blockage rates of 0.43, 3, 6, and 12 percent. The amount of flow that had to be removed from the plenum chamber (which surrounded the slotted test section) by the plenum evacuation system (PES) to eliminate wall interference effects was determined. The effectiveness of tunnel reentry flaps in removing flow from the plenum chamber was examined. The 0.43-percent blockage model was the only one free of wall interference effects with no PES flow. Surface pressures on the forward part of the other models were greater than interference-free results and were not influenced by PES flow. Interference-free results were achieved on the aft part of the 3- and 6-percent blockage models with the proper amount of PES flow. The required PES flow was substantially reduced by opening the reentry flaps