Aerobic oxidation of aryl-himachalene using a combination of N-hydroxy phthalimide and cobalt(II) acetoacetate

An efficient aerobic oxidation of Ar-himachalene as bio-natural sesquiterpene employing the N-hydroxyphthalimide (NHPI), under mild conditions in presence of cobalt (II) afforded the corresponding alcohol, aldehyd and carboxylic acid in excellent yield and good selectivities. Keywords : Aerobic oxidation, Ar-himachalene, sesquiterpene, NHPI

Natural phosphate as new, highly efficient and reusable heterogeneous catalyst for the selective preparation of beta-enaminoesters under solvent-free conditions

Natural phosphate (NP) has been found to be a new and highly efficient heterogeneous catalyst for the synthesis of beta-enaminoesters, by simple condensation of various primary amines with beta-dicarbonyl under solvent-free conditions. Keywords: Natural phosphate (NP), b-enaminoesters, solvent-free condition

Development of a Sustainable and Solventless Friedel-Crafts Acylation Reaction of an Aromatic Natural Product “Ar-Himachalene” over Nanostructured ZnO as a New Catalyst

We describe the development of a sustainable and solventless acylation reaction of the naturally occurring product, namely 2,5,9,9-tetramethyl-6,7,8,9-tetrahydro-5H-benzocycloheptene [ar-himachalene], with acid chlorides over a new type of flower-shaped ZnO nanosructure as a hetrogenous catalyst at room temperature. The ZnO nanoflowers can efficiently and selectively catalyze the acylation of the aromatic group of ar-himachalene and be reused up to three times by simple filtration and washing without significant loss in their catalytic activity. Keywords: Acylation, Natural product, Solventless, Zin Oxide nanostructure, Heterogenous Catalysis, Sustainability

4-Chloro-N-methyl-2-(1,2,3,4-tetra­hydro­isoquinolin-1-yl)aniline

The racemic title compound, C16H17ClN2, shows a tetra­hydro­isoquinoline skeleton with a 4-chloro-N-methyl­aniline group linked to the C atom at position 1. The dihedral angle between the benzene rings is 85.82 (4)°. An intra­molecular N—H⋯N hydrogen bond occurs. In the crystal, mol­ecules are linked through inter­molecular C—H⋯π inter­actions

[(1R)-3-Benzoyl-1,7,7-trimethyl­bicyclo­[2.2.1]heptan-2-onato-κ2 O,O′]chlorido(η6-p-cymene)ruthenium(II)

The asymmetric unit of the title compound, [RuCl(C10H14)(C17H19O2)], contains two diastereomers. In both, the RuII ion has a tetra­hedral coordination, formed by two O atoms of the camphor-derived ligand and the p-cymene and Cl ligands. In the crystal structure, weak inter­molecular C—H⋯Cl inter­actions link the mol­ecules into columns propagated along [010]

1,10,10-Trimethyl-5-phenyl-3-oxa-4-azatricyclo[5.2.1.02,6]dec-4-en-2-ol

The title compound, C17H21NO2, was synthesized by the reaction of (1R)-(+)-3-benzylcamphor and hydroxylamine. The oxazole ring makes a dihedral angle of 23.42 (16)° with the phenyl ring. The six-membered ring of the norboryl group adopts a boat conformation, whereas each of the five-membered rings of the norboryl group displays a flattened envelope conformation, with the C atom carrying the methyl groups representing the flap for both rings. In the crystal, molecules are linked into zigzag chains propagating along the b axis by O—H...N hydrogen bonds

(R)-2-Methyl-5-[(R)-2,4,4,4-tetrachlorobutan-2-yl]cyclohex-2-enone

The title compound, C11H14Cl4O, was efficiently synthesized by atom-transfer radical addition between (R)-carvone and tetrachloromethane. In the molecule, both chiral centres are of the absolute configuration R. The cyclohex-2-enone ring has an envelope conformation with the chiral C atom displaced by 0.633 (2) Å from the mean plane through the other five C atoms [maximum deviation = 0.036 (2) Å]. In the crystal, molecules are linked via C—H...O interactions, leading to the formation of helical chains propagating along [100]

(2Z,2′Z)-Diethyl 3,3′-[butane-1,4-diylbis(azanediyl)]bis(but-2-enoate)

The whole molecule of the title β-enaminoester, C16H28N2O4, is generated by a crystallographic inversion center, situated at the mid-point of the central C—C bond of the 1,4-diaminobutane segment. There are two intramolecular N—H...O hydrogen bonds that generate S(6) ring motifs. This leads to the Z conformation about the C=C bonds [1.3756 (17) Å]. The molecule is S-shaped with the planar central 1,4-diaminobutane segment [maximum deviation for non H-atoms = 0.0058 (13) Å] being inclined to the ethyl butylenonate fragment [C—C—O—C—C=C—C; maximum deviation = 0.0710 (12) Å] by 15.56 (10)°. In the crystal, molecules are linked via C—H...O interactions, leading to the formation of an undulating two-dimensional network lying parallel to the bc plane