21 research outputs found
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«ç掻æ§ã®é«ãååç©ãèŠåºãããæ¬ååç©ã¯è¬å€èæ§ãã现èã«ãæå¹ã§ãã£ãã1. A simple and general synthesis of protoberberines and 13-methylprotoberberines via the same synthetic intermediates was newly developed. This method was applied to a new synthesis of protoberberine alkaloids.2. A novel biomimetic synthesis of benzophenanthridines form protoberberines through the enamine intermediates was developed. Benzophenanthridine alkaloids such as chelerythrine and nitidine were synthesized by this method.3. A new and simple synthesis of isocoumarins was developed employing palladium-catalyzed cyclization of o-alkenylbenzoic acids. This method was applied to a synthesis of a benzophenanthridine.4. Synthesis of hexahydrobenzophenanthridine alkaloids, corynoline and its stereoisomeric alkaloids from corresponding 13-methylprotoberberine alkaloid, corysamine was succeeded through a newly developed biomimetic route. An alkaloid having a unique substitution pattern, ambinine was totally synthesized by this method.5. A pyridoacridine skeleton was synthesized by a coupling reaction of quinoline derivative with phenylboric acid or phenyltin compound. Synthesis of antitumor marine alkaloids, cystodytin J and deplamine, was successfully realized by this method.6. We found a benzophenanthridine compound having high antitumor activity as well as activity against drug-resistant tumor cell.ç 究課é¡/é åçªå·:09557199, ç 究æé(幎床):1997 â 1999åºå
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åŠæŽ»æ§ãã³ãºã¢ã«ãããããå°ãããããã³ãšãªã¬ãã£ã³ãšã®1,3-å極åç°ç¶ä»å åå¿ã§ç«äœéžæçã«cis-3,5-ãžçœ®æã€ãœããµãŸãªãžã³äœãäžããã1. Chirai aldol reaction of the chiral benzaldehyde with silyl ketene acetals afforded anti-aldol products with highly stereoselectivity. Thus, chirality of the chiral benzaldehyde was effectively transformed to a chiral carbon chain.2. Aldol reaction of the chiral benzaldehyde with a titanium enolate derived form a thioester gave stereoselectively an anti-aldol product.3. Common synthetic intermediate having four continuous asymmetric carbons was synthesized in highly stereoselective manner and highly optical yield from the chiral benzaldehyde through twice aldol reactions. Total synthesis of styryllactones having a 5-membered lactone, goniofufurone, goniobutenolide A and B was achieved.4. Conversion of a 5-membered lactone to a 6-membered lactone through a lactol was developed. According to this method, styryllactones having a 6-membered lactone, goniodiol, goniotriol, 8-acetylgoniotriol, altholactone, and 9-deoxygoniopypyrone were synthesized.5. Chiral total synthesis of goniofupyrone was succeeded. This synthesis established the structure of goniofupyrone including absolute stereochemistry and revised the previously proposed structure.6. The structure of gonioheptolide A was revised by its synthesis from goniofupyrone. The proposed 8-membered lactone structure was found to be incorrect.7. Amino acid part of AI-77B, an antiulcerogenic antibiotic, and AI-77B analogue were synthesized from the chiral benzaldehyde.8. 1,3-Dipolar cycloaddition of chiral nitrons, derived form the chiral benzaldehyde, with olefins gave stereoselectively cis-3,5-disubstituted isoxazolidines.ç 究課é¡/é åçªå·:09470484, ç 究æé(幎床):1997 â 1999åºå
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