PERIPHERAL AMELOBLASTOMA OF THE BUCCAL MUCOSA : WITH A REVIEW OF THE LITERATURE

A peripheral ameloblastoma arising on the buccal mucosa is exceedingly rare. Only three document cases have been reported, and we present one additional case of this tumor. In this case, the lesion repeatedly occurred in the same location in spite of twice local excisions. The first lesion was diagnosed as basal cell carcinoma with ameloblastomatous features. The pathological findings of the lesion were palisading of the peripheral cells of epithelial masses and structures resembling stellate reticulum, which could also be observed also in peripheral ameloblastomas. The second lesion was diagnosed as basal cell adenoma, and the third as peripheral ameloblastoma. The histogenesis of peripheral ameloblastomas and intraoral basal cell carcinomas are discussed, especially with reference to the lesions of the buccal mucosa

Expression of c-myc, c-fos and CA19-9 in Human Non-Malignant and Malignant Gallbladder Tissues

Immunohistochemical study was performed on expressions of c-myc, c-fos and CA19-9 in gallbladder tissue with or without malignant lesions. A total of 81 tissues were divided into four groups including 47 carcinomas, 3 dysplasias, 17 metaplasias and 14 normal lesions. After these tissues were routinely fixed in 10% formalin solution and embedded in paraffin, 4 micrometer-thick sections were made and stained with hematoxylin-eosin to classify the type of lesions. Immunohistochemical stains were carried out for c-myc and c-fos oncoproteins, and CA19-9. The percentages of positive reaction for c-myc oncoprotein were 77%, 67%, 88% and 36%, those for c-fos oncoprotein were 83%, 66%, 35% and 7%, and those for CA19-9 were 85%, 100%, 88% and 71% in carcinoma, dysplasia, metaplasia and normal tissues, respectively. These results suggest that c-myc and c-fos oncogenes play some kind of roles in malignant transformation of the gallbladder tissues and that abnormal expression of CA19-9 is the sign of antigen reversion of carcinoma cells toward embryonic cells of the gallbladder tissue

Morphological and Biochemical Evaluation of the Induction of Atherosclerosis in Japanese Quails

A total of 77 birds were divided into 7 groups which were fed the following diets : Group I, basal ; Group II, 5% corn oil (CO) + 0.5% cholesterol (CH) ; Group III, 5% CO + 2% CH; Group IV, 5% CO + 4% CH; Group V, 15% CO + 0.5% CH ; Group V I, 15% CO + 2% CH; Group VII, 15% CO + 4% CH. Significant increase of serum lipid, accumulation of lipid in the liver, and lipid-rich aortic lesions were produced in Groups IV, VI and VIII. However, hyperlipidemia correlated well with the extent of hepatic lipid accumulation and severity of aortic atherosclerosis in Group VI. Proliferating intimal cells showed positive reaction to antibodies for vimentin and alpha-1-antichymotrypsin implicating an important role of phenotypical transformation of intimal cells from the medial fibroblastic cells in the development of aortic atherosclerosis. These results suggest that Japanese quail is highly susceptible to atherosclerosis, and the optimal dietary level of cholesterol and corn oil is 2% and 15%, respectively to induce lipid-rich aortic lesions in Japanese quail

Evaluation of angiotensin-converting enzyme-inhibitory activity in abalone viscera fermented by Lactobacillus casei 001

Abalone viscera are typically discarded in the food industry. This study evaluated the potential use of abalone viscera as a functional food. After fermentation by lactic acid bacteria, namely Lactobacillus casei 001, abalone viscera exhibited the ability to inhibit angiotensin-converting enzyme (ACE) and suppressed blood pressure increases in healthy mice and spontaneously hypertensive rats. Purification and characterization of extracts derived from fermented abalone viscera showed that the active component was homarine, which exhibited strong, noncompetitive ACE-inhibitory capacity. Altogether, these findings suggest that abalone viscera fermented by lactic acid bacteria hold potential as functional food materials to manage blood pressure