The origin of alteration “orangettes” in Dhofar 019: Implications for the age and aqueous history of the shergottites

The shergottites are the largest group of Martian meteorites, and the only group that has not been found to contain definitive evidence of Martian aqueous alteration. Given recent reports of current liquid water at the surface of Mars, this study aimed to investigate in detail the possibility of Martian phyllosilicate within shergottite Dhofar 019. Optical and scanning electron microscopy, followed by transmission electron microscopy, confirmed the presence of alteration orangettes, with a layered structure consisting of poorly ordered Mg-phyllosilicate and calcite. These investigations identified maskelynite dissolution, followed by Mg-phyllosilicate and calcite deposition within the dissolution pits, as the method of orangette production. The presence of celestine within the orangette layers, the absence of shock dislocation features within calcite, and the Mg-rich nature of the phyllosilicate, all indicate a terrestrial origin for these features on Dhofar 019

Compositional analysis of the very-low-Ti mare basalt component of NWA 773 and comparison with low-Ti basalts, LAP03632 and LAP02436

Abstract not available

Porosity Variations Between Fine Grained Rims and Matrix in a CM Chondrite by 3D Serial Sectioning

No abstract available

Northwest Africa 11522: A New Paired Stone of Martian Polymict Regolith Breccia Northwest Africa 7034

No abstract available

Atomic Scale Depth Profile of Space Weathering in an Itokawa Olivine Grain

No abstract available

TUGAS KELUARGA DALAM PEMELIHARAAN KESEHATAN DENGAN MEKANISME KOPING LANSIA

Keluarga merupakan unit terkecil dari masyarakat yang memiliki pengaruh kuat terhadap perkembangan individu. Adanya dukungan keluarga yang positif, juga akan membantu individu dengan mudah menghadapi setiap problem yang ada, termasuk mekanisme koping. Tujuan penelitian ini untuk mengetahui hubungan tugas keluarga dalam pemeliharaan kesehatan dengan mekanisme koping lansia di wilayah RT 04 RW 01 Guyangan Tlogomas Malang.Desain penelitian yang digunakan adalah deskriptif korelatif model cross sectional study, dengan populasi seluruh lansia dan keluarga lansia berjumlah 60 orang. Pengambilan sampel dilakukan secara simpel random sampling berjumlah 52 keluarga dan lansia serta teknik analisa data spearman rank.Hasil didapatkan sebagian besar 29 (56%) keluarga dapat melaksanakan pemeliharaan terhadap lansia secara baik, sebagian besar 38 (73%) lansia dapat melakukan mekanisme koping secara adaptif dan terdapat hubungan yang signifikan antara tugas keluarga dalam pemeliharaan kesehatan dengan mekanisme koping Lansia. Saran perlu dikaji dengan menambahkan faktor-faktor yang mempengaruhi skor tugas keluarga dengan mekanisme kopin

Atomic Scale Depth Profile of Space Weathering in an Itokawa Olivine Grain

No abstract available

Fluorescent Cascade and Direct Assays for Characterization of RAF Signaling Pathway Inhibitors

RAF kinases are part of a conserved signaling pathway that impacts cell growth, differentiation, and survival, and RAF pathway dysregulation is an attractive target for therapeutic intervention. We describe two homogeneous fluorescent formats that distinguish RAF pathway inhibitors from direct RAF kinase inhibitors, using B-RAF, B-RAF V599E, and C-RAF. A Förster-resonance energy transfer (FRET) based method was used to develop RAF and MEK cascade assays as well as a direct ERK kinase assay. This method uses a peptide substrate, that is terminally labeled with a FRET-pair of fluorophores, and that is more sensitive to proteolysis relative to the phosphorylated peptide. A second time-resolved FRET-based assay using fluorescently labeled MEK substrate was used to detect direct inhibitors of RAF kinase activity. The cascade assays detect compounds that interact with activated and unactivated kinases within the recapitulated RAF pathway, and the direct assays isolate the point of action for an inhibitor

An observational, cohort, multi-centre, open label phase IV extension study comparing preschool DTAP-IPV booster vaccine responses in children whose mothers were randomised to one of two pertussis-containing vaccines or received no pertussis-containing vaccine in pregnancy in England.

An antenatal pertussis vaccination programme was introduced in 2012 in the UK in the context of a national outbreak of pertussis. It has been shown that a lower antibody response to primary immunisation can be seen for certain pertussis antigens in infants born to women who received pertussis-containing antenatal vaccines, a phenomenon known as blunting. The longer-term impact of this has not been documented previously, and accordingly was evaluated in this study. Children were predominantly recruited from a previous study in which their mothers had received acellular pertussis-containing antenatal vaccines (dTaP3-IPV [diphtheria toxoid, tetanus toxoid, three antigen acellular pertussis and inactivated polio] or dTaP5-IPV [diphtheria toxoid, tetanus toxoid, five antigen acellular pertussis and inactivated polio]), or no pertussis-containing vaccine. Blood samples were obtained prior to and one month after the acellular pertussis-containing preschool booster (dTaP5-IPV) was given at around age 3 years 4 months. Pre- and post-booster immunoglobulin G (IgG) geometric mean concentrations (GMCs) against pertussis toxin, filamentous haemagglutinin, fimbriae 2 & 3, and pertactin, were compared. Prior to the receipt of the preschool booster, there was no difference in the IgG GMCs against pertussis-specific antigens between children born to women vaccinated with dTaP3-IPV and dTaP5-IPV; however, IgG GMCs against pertussis toxin were significantly lower in children born to women vaccinated with dTaP3-IPV compared with children born to unvaccinated women (geometric mean ratio 0.42 [95 % CI 0.22-0.78], p = 0.03). One month after the receipt of the preschool booster there was no differences between the groups. The blunting effect of antenatal pertussis vaccine on pertussis responses in children can persist until preschool age, although it is overcome by the administration of a booster dose. ClinicalTrials.gov registration number: NCT03578120