Simulations of Combined Solar Thermal and Heat Pump Systems for Domestic Hot Water and Space Heating

AbstractThe system combination of solar thermal collectors and heat pumps is a very attractive option for increasing the renewable energy usage at worldwide level for heating and domestic hot water preparation. In this work parallel and series combined solar and heat pump systems are analyzed within the IEA SHC Task44/HPP Annex38 reference conditions for different buildings and a typical Central European climate. Three combined systems have been studied in detail: solar and air source heat pump, solar and ground source heat pump, and exclusively solar source heat pump in combination with an ice storage. Numerical calculations have been performed using two simulation platforms: TRNSYS-17 and Polysun-6®. Comparisons between the two simulation environments have been also provided. Moreover, a reference case without solar has been used to determine the potential efficiency benefits of using solar collectors compared to a system with a heat pump alone in the specified climate and for covering the specified heat load. Simulations presented in this work show that differences in system performance up to 4% can be expected between TRNSYS-17 and Polysun-6® for air source based systems, and higher discrepancies, up to 14% are obtained for ground source based systems. Comparisons between combined solar thermal and heat pump systems with their respective “heat pump only” reference solutions show that the absolute electricity savings of air source are usually higher compared to ground source based systems. Systems using large ice storages are able to reach seasonal performance factors in the range of 5, which is of the order of performance of combined solar and ground source heat pump systems

Sexual and Reproductive Health Behaviors of Undocumented Migrants in Geneva: A Cross Sectional Study

Undocumented migrants face major barriers in accessing prevention and health care. Whereas the association between low socioeconomic status and poor health is well documented only few studies have addressed specific health issues in undocumented migrants. The aim of the present study is to describe sexual and reproductive health behaviors of undocumented migrants in Geneva. This descriptive cross sectional study included consecutive undocumented migrants presenting from November 2007 to February 2008 to a health facility offering free access to health care to this population. Following informed consent, they completed a self administered questionnaire about their socio-demographic profile and sexual and reproductive health behaviors. A total of 384 patients were eligible for the study. 313 (82%) agreed to participate of which 77% (241 patients) completed the survey. Participants were mainly young, Latino-American, single, well-educated and currently working women. They had multiple partners and reported frequently engaging in sexual intercourse. Use of contraceptive methods and strategies of prevention against sexually transmitted infections (STI) were rare. Nearly half of the women had had at least one induced abortion and 40% had had an unplanned pregnancy. One in four participants reported a current or past STI or other genital infection. The results of our study suggest that undocumented migrants engage in frequent and high risk sexual intercourse with insufficient use of contraceptive methods and suboptimal strategies of prevention against STI. Our study underlines the real need for specific sexual and reproductive educational programs targeting this hard to reach populatio

Effect of crew resource management training in a multidisciplinary obstetrical setting

Objective To assess the effect of a Crew Resource Management (CRM) intervention specifically designed to improve teamwork and communication skills in a multidisciplinary obstetrical setting. Method Design-A before-and-after cross-sectional study designed to assess participants' satisfaction, learning and change in behaviour, according to Kirkpatrick's evaluation framework for training programmes. Setting-Labour and delivery units of a large university-affiliated hospital. Participants-Two hundred and thirty nine midwives, nurses, physicians and technicians from the department of anaesthesia, obstetrics and paediatrics. Intervention-All participants took part in a CRM-based training programme specifically designed to improve teamwork and communication skills. Principal measures of outcome-We assessed participants' satisfaction by means of a 10-item standardized questionnaire. A 36-item survey was administered before and after the course to assess participants' learning. Behavioural change was assessed by a 57-item safety attitude questionnaire measuring staff's change in attitude to safety over 1 year of programme implementation. Results Most participants valued the experience highly and 63-90% rated their level of satisfaction as being very high. Except for seven items, the 36-item survey testing participants' learning demonstrated a significant change (P < 0.05) towards better knowledge of teamwork and shared decision making after the training programme. Over the year of observation, there was a positive change in the team and safety climate in the hospital [odds ratio (OR) 2.9, 95% confidence interval (CI) (1.3-6.3) to OR 4.7, 95% CI (1.2-17.2)]. **There was also improved stress recognition [OR 2.4, 95% CI (1.2-4.8) to OR 3.0, 95% CI (1.0-8.8)]. Conclusion The implementation of a training programme based on CRM in a multidisciplinary obstetrical setting is well accepted and contributes to a significant improvement in interprofessional teamwor

Extensive geothermal heat use in cities energetic and economic comparison of options for thermal regeneration of the ground

Geothermal energy as a heat source for heat pumps is increasingly unused in the city of Zürich. However, as indicated by other authors, the renewable potential for shallow geothermal heat use is limited due to the fact that natural regeneration in the absence of ground water flow is slow. Constant heat extractions from dense geothermal heat pump installations continuously cool down the affected ground layer.. In this case boreholes have to be drilled deeper or regenerated in order to avoid freezing around the borehole. The aim of this simulation study is to find the most economic geothermal heat pump concept, which does not lead to borehole freezing after 50 years of operation in areas with dense installations (an exemplary mean geothermal heat extraction of 35kWh/m2/a was supposed for this this study). Therefor a multi-family house with a standard ground source heat pump was simulated for a period of 50 years in Polysun. Various solar concepts, an air heat exchanger concept, a geo cooling concept and also a system without regeneration were added to the system. These concepts were compared under the assumption that all neighboring installations are using an equivalent regeneration strategy as the simulated system For the different system concepts, highly variable total borehole length were needed to avoid freezing, reaching from 1020m for a system with a large glazed collector field to 2160m for the un-regenerated case. The heat cost of the analyzed system concepts was in the range of 21- 27 Rp/kWh. The most cost-effective system concepts according to this analysis are the air heat exchanger or unglazed collectors. Increasing the total borehole meters was not only one of the most expensive options, but also the least sustainable, since the continuation of ground tem-perature decrease after 50 years was more pronounced with this option than for any other option

SOLAR &amp; PELLET HEATING: SPECIFICATIONS FOR HIGH EFFICIENCY SYSTEM DESIGN

Abstract Combined biomass and solar heating systems provide the opportunity for a heat supply of single family houses without the use of fossil energy. Pellet fired boilers play a predominant role within these systems because their standardised combustible allows for the fully automated operation. However, the combination of biomass boilers and solar collectors places special requirements in view of a good system solution. To analyse the proper combination of both technologies three separate projects were carried out at SPF. the main instrument thereby was the Concise Cycle Test method supplemented by preliminary tests of the boiler and subsequent simulations. It was shown that a modulating boiler operation is superior in terms of both, high energetic efficiency and low emissions compared to intermitting boiler operation. But this is only the case if the following requirements are met: Low excess-air factors for the complete modulation range, low envelope losses, a fast adaption of the output power, correct dimensioning of the boiler. Beside the characteristics of the boiler the hydraulic connection and the control is important to reach a good system performance. Mostly for combined biomass and solar heating systems the best solution is a connection of the boiler to the thermal energy store instead of a direct connection to the heating circuit. The requirements that have to be fulfilled for the control of TES charging are: Temperature sensors within the store to control the boiler dependent to the demand for space heating or domestic hot water. In order to control the power modulation of the boiler, the best option is to reduce the volume flow rate of the boiler pump based on an algorithm that takes into account the temperature measured in the TES. Other options are to increase the return temperature of the boiler using a motorized mixing valve, or to reduce the set-temperature for the water leaving the boiler

Prevalence and Associated Factors for Chlamydia trachomatis Infection Among Undocumented Immigrants in a Primary Care Facility in Geneva, Switzerland: A Cross-Sectional Study

Chlamydia trachomatis infection (CTI) is the most frequent sexually transmitted infection in western countries. Its prevalence in undocumented immigrants, a rapidly growing vulnerable population, remains unknown. We aimed to document the prevalence of CTI and associated factors at the primary health care level. This cross-sectional study included all undocumented immigrants attending a health care facility in Geneva, Switzerland. Participants completed a questionnaire and were tested for CTI by PCR assay. Three-hundred thirteen undocumented immigrants (68.4% female, mean age 32.4 (SD 8) years) agreed to participate. CTI prevalence was 5.8% (95% CI 3.3-8.4). Factors associated with higher prevalence were age ≤25 (OR 3.9, 95% CI 1.3-12.2) and having had two or more sexual partners during the precedent year (OR 4.5, 95% CI 1.5-13.7). Prevalence and associated factors for infection in this vulnerable population were comparable with other populations in Western countries. Our findings support the importance of facilitating access to existing screening opportunities in particular to individuals at higher ris

Nationally representative results on SARS-CoV-2 seroprevalence and testing in Germany at the end of 2020

Pre-vaccine SARS-CoV-2 seroprevalence data from Germany are scarce outside hotspots, and socioeconomic disparities remained largely unexplored. The nationwide representative RKI-SOEP study (15,122 participants, 18–99 years, 54% women) investigated seroprevalence and testing in a supplementary wave of the Socio-Economic-Panel conducted predominantly in October–November 2020. Self-collected oral-nasal swabs were PCR-positive in 0.4% and Euroimmun anti-SARS-CoV-2-S1-IgG ELISA from dry-capillary-blood antibody-positive in 1.3% (95% CI 0.9–1.7%, population-weighted, corrected for sensitivity = 0.811, specificity = 0.997). Seroprevalence was 1.7% (95% CI 1.2–2.3%) when additionally correcting for antibody decay. Overall infection prevalence including self-reports was 2.1%. We estimate 45% (95% CI 21–60%) undetected cases and lower detection in socioeconomically deprived districts. Prior SARS-CoV-2 testing was reported by 18% from the lower educational group vs. 25% and 26% from the medium and high educational group (p < 0.001, global test over three categories). Symptom-triggered test frequency was similar across educational groups. Routine testing was more common in low-educated adults, whereas travel-related testing and testing after contact with infected persons was more common in highly educated groups. This countrywide very low pre-vaccine seroprevalence in Germany at the end of 2020 can serve to evaluate the containment strategy. Our findings on social disparities indicate improvement potential in pandemic planning for people in socially disadvantaged circumstances

Nationally representative results on SARS-CoV-2 seroprevalence and testing in Germany at the end of 2020

Pre-vaccine SARS-CoV-2 seroprevalence data from Germany are scarce outside hotspots, and socioeconomic disparities remained largely unexplored. The nationwide representative RKI-SOEP study (15,122 participants, 18–99 years, 54% women) investigated seroprevalence and testing in a supplementary wave of the Socio-Economic-Panel conducted predominantly in October–November 2020. Self-collected oral-nasal swabs were PCR-positive in 0.4% and Euroimmun anti-SARS-CoV-2-S1-IgG ELISA from dry-capillary-blood antibody-positive in 1.3% (95% CI 0.9–1.7%, population-weighted, corrected for sensitivity = 0.811, specificity = 0.997). Seroprevalence was 1.7% (95% CI 1.2–2.3%) when additionally correcting for antibody decay. Overall infection prevalence including self-reports was 2.1%. We estimate 45% (95% CI 21–60%) undetected cases and lower detection in socioeconomically deprived districts. Prior SARS-CoV-2 testing was reported by 18% from the lower educational group vs. 25% and 26% from the medium and high educational group (p < 0.001, global test over three categories). Symptom-triggered test frequency was similar across educational groups. Routine testing was more common in low-educated adults, whereas travel-related testing and testing after contact with infected persons was more common in highly educated groups. This countrywide very low pre-vaccine seroprevalence in Germany at the end of 2020 can serve to evaluate the containment strategy. Our findings on social disparities indicate improvement potential in pandemic planning for people in socially disadvantaged circumstances.Peer Reviewe

HIV-1 Nef Employs Two Distinct Mechanisms to Modulate Lck Subcellular Localization and TCR Induced Actin Remodeling

The Nef protein acts as critical factor during HIV pathogenesis by increasing HIV replication in vivo via the modulation of host cell vesicle transport and signal transduction processes. Recent studies suggested that Nef alters formation and function of immunological synapses (IS), thereby modulating exogenous T-cell receptor (TCR) stimulation to balance between partial T cell activation required for HIV-1 spread and prevention of activation induced cell death. Alterations of IS function by Nef include interference with cell spreading and actin polymerization upon TCR engagement, a pronounced intracellular accumulation of the Src kinase Lck and its reduced IS recruitment. Here we use a combination of Nef mutagenesis and pharmacological inhibition to analyze the relative contribution of these effects to Nef mediated alterations of IS organization and function on TCR stimulatory surfaces. Inhibition of actin polymerization and IS recruitment of Lck were governed by identical Nef determinants and correlated well with Nef's association with Pak2 kinase activity. In contrast, Nef mediated Lck endosomal accumulation was separable from these effects, occurred independently of Pak2, required integrity of the microtubule rather than the actin filament system and thus represents a distinct Nef activity. Finally, reduction of TCR signal transmission by Nef was linked to altered actin remodeling and Lck IS recruitment but did not require endosomal Lck rerouting. Thus, Nef affects IS function via multiple independent mechanisms to optimize virus replication in the infected host