Mathematical modeling of extracorporeal CO2 removal

Extra¬cor¬poreal CO2 removal devices (ECCO2R) can be used in clinics to decarboxylate blood externally for patients suffering from pulmonary insufficiencies like acute respiratory distress syndrome. In this work, a model of the respiratory system coupled with such a device is proposed to analyze the decrease of CO2 partial pressure in blood as a function of blood flow through the device. This model provides a mathematical tool which could help clinicians to choose the optimal settings of ECCO2R.Mathematical modeling and optimization of the use of cardiopulmonary assistances in intensive care unit

Patient-specific modelling of extracorporeal life support therapy

Les assistances cardio-respiratoires extracorporelles, souvent désignées par l’abréviation anglophone ECLS (ExtraCorporeal Life Support), sont déjà largement utilisées dans de nombreux hôpitaux. Ces assistances permettent de subvenir aux besoins vitaux de pa- tients souffrant de maladies respiratoires et/ou cardio-vasculaires sévères. Cependant, les cliniciens restent encore confrontés à plusieurs problèmes liés à l’utilisation de ces ap- pareils médicaux et certaines améliorations des approches thérapeutiques associées seraient souhaitables. Dans cette thèse, nous développons des modèles mathématiques simplifiés des systèmes respiratoire et cardiovasculaire couplés à un modèle d’ECLS. La plupart des paramètres qui apparaissent dans la description sont déterminés à partir de données cliniques et les modèles proposés sont donc patient-spécifiques. Ces modèles permettent de tester in silico diverses options thérapeutiques et devraient donc permettre au clinicien d’optimiser l’utilisation de l’ECLS. Dans notre travail, une première validation des modèles mathématiques a été réalisée à l’aide de données expérimentales obtenues à partir de modèles animals sur le cochon. Ensuite, une seconde validation a été réalisée en utilisant des données cliniques. Les résultats obtenus sont très prometteurs et constituent une perspective encourageante dans le développement d’un outil qui permettra une utilisation des ECLS plus efficace et adaptée à chaque patient

Mathematical modeling of extracorporeal CO2 removal therapy. A validation carried out on ten pigs

The extracorporeal CO2 removal device (ECCO2RD) is used in clinics to treat patients suffering from respiratory failures like acute respiratory distress syn- drome (ARDS) or chronic obstructive pulmonary disease (COPD). The aim of this device is to decarboxylate blood externally with low blood flow. A mathematical model is proposed to describe protective ventilation, ARDS, and an extracorporeal CO2 removal therapy (ECCO2RT). The sim- ulations are compared with experimental data carried out on ten pigs. The results show a good agreement between the mathematical simulations and the experimental data, which provides a nice validation of the model. This model is thus able to predict the decrease of PCO2 during ECCO2RT for different blood flows across the extracorporeal lung support

Size of cannula for extracorporeal CO2 removal therapies

Extracorporeal CO2 removal devices (ECCO2R) can be used in clinics to decarboxylate blood externally for patients suffering from pulmonary insufficiencies like acute respiratory distress syndrome. In this work, we propose a model of the respiratory system coupled with such a device to analyze the decrease of CO2 partial pressure in the blood as a function of the blood flow through the device. Thanks to this information, the size of the cannulae can be optimized.Mathematical modeling and optimization of the use of cardiopulmonary assistances in intensive care unit

Importance of Metabolism Variations in a Model of Extracorporeal Carbon Dioxide Removal

peer reviewedExtracorporeal CO2 Removal device is used in clinics when a patient suffers from a pulmonary insufficiency like Acute Respiratory Distress Syndrome and allows to decarboxylate blood externally. In this work, a model of the respiratory system coupled with such a device is proposed to analyze the decrease of CO2 partial pressure in blood. To validate the model, some parameters are estimated thanks to experimental data. Metabolism is a crucial parameter and we show that its time evolution must be taken into account in order to have correct CO2 partial pressure simulations in arteries and in veins.Mathematical modeling and optimization of the use of cardiopulmonary assistances in intensive care unit

A mathematical model of respiration under protective ventilation and extracorporeal CO2 removal therapy

The aim of the present study is to build a mathematical model of the respiratory system connected to an extracorporeal CO2 removal device (ECCO2RD) to optimize the gas exchanges efficiency. The model must be simple enough to provide rapid solutions and to estimate specific parameters from available clinical data. But it also must be complex enough to be able to simulate the respiratory system when protective ventilation is used and when this system is assisted by an ECCO2RD.Mathematical modeling and optimization of the use of cardiopulmonary assistances in intensive care unit

Model-Based Weaning Tests for VA-ECLS Therapy

MOCA, PDR T.1058.1