226 research outputs found

    Monsoons

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    This study was supported by the Institute for Basic Science (project code IBS-R028-D1). I would like to express my sincere thanks to all of authors, reviewers, and assistant editors for their effort to this special issue

    Nonlinear forced change and nonergodicity: The case of ENSO-Indian monsoon and global precipitation teleconnections

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    We study the forced response of the teleconnection between the El Nino-Southern Oscillation (ENSO) and global precipitation in general and the Indian summer monsoon (IM) in particular in the Max Planck Institute Grand Ensemble. The forced response of the teleconnection is defined as the time-dependence of a correlation coefficient evaluated over the ensemble. The ensemble-wise variability is taken either wrt. spatial averages or dominant spatial modes in the sense of Maximal Covariance Analysis or Canonical Correlation Analysis or EOF analysis. We find that the strengthening of the ENSO-IM teleconnection is robustly or consistently featured in view of all four teleconnection representations, whether sea surface temperature (SST) or sea level pressure (SLP) is used to characterise ENSO, and both in the historical period and under the RCP8.5 forcing scenario. The main contributor to this strengthening in terms of a linear regression model is the regression coefficient, which can outcompete even a declining ENSO variability in view of using the SLP. We also find that the forced change of the teleconnection is typically nonlinear by (1) formally rejecting the hypothesis that ergodicity holds, i.e., that expected values of temporal correlation coefficients with respect to the ensemble equal the ensemble-wise correlation coefficient itself, and also showing that (2) the trivial contributions of the forced changes of e.g. the mean SST and/or precipitation to temporal correlations are insignificant here. We also provide, in terms of the test statistics, global maps of the degree of nonlinearity/nonergodicity of the forced change of the teleconnection between local precipitation and ENSO

    Impacts of an aerosol layer on a mid-latitude continental system of cumulus clouds: how do these impacts depend on the vertical location of the aerosol layer?

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    Using the large-eddy simulation framework, effects of an aerosol layer on warm cumulus clouds in the Korean Peninsula when the layer is above or around the cloud tops in the upper atmosphere are examined. Also, these effects are compared to effects of an aerosol layer when it is around or below the cloud bases in the low atmosphere. Simulations show that when the aerosol layer is in the low atmosphere, aerosols absorb solar radiation and radiatively heat up air enough to induce greater instability, stronger updrafts and more cloud mass than when the layer is in the upper atmosphere. As aerosol concentrations in the layer decrease, the aerosol radiative heating gets weaker to lead to less instability, weaker updrafts and less cloud mass when the layer is in the low atmosphere. This in turn makes differences in cloud mass, which are between a situation when the layer is in the low atmosphere and that when the layer is in the upper atmosphere, smaller. It is found that the transportation of aerosols by updrafts reduces aerosol concentrations in the aerosol layer, which is in the low atmosphere, and in turn reduces the aerosol radiative heating, updraft intensity and cloud mass. It is also found that the presence of aerosol impacts on radiation suppresses updrafts and reduces clouds. Aerosols affect not only radiation but also aerosol activation. In the absence of aerosol impacts on radiation, aerosol impacts on the droplet nucleation increases cloud mass when the layer is in the low atmosphere as compared to a situation when the layer is in the upper atmosphere. As aerosol impacts on radiation team up with those on the droplet nucleation, differences in cloud mass, which are between a situation when the layer in the low atmosphere and that when the layer is in the upper atmosphere, get larger. This is as compared to a situation when there is no aerosol impacts on radiation and only aerosol impacts on the droplet nucleation.</p

    Simultaneous Total Occlusion of Multiple Distal Coronary Arteries in Acute Myocardial Infarction

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    Simultaneous multiple coronary artery thrombosis is a rare finding in ST segment elevation myocardial infarction (STEMI). We report a case of myocardial infarction with multiple ST segment elevation on the electrocardiography and total occlusions of the distal left anterior descending artery (dLAD), as well as of the second and third obtuse marginal artery on emergency coronary angiography. Thrombus aspiration was performed at dLAD and systemic glycoprotein IIb/IIIa inhibitor was used successfully. In patients with STEMI, multiple coronary thromboses are unusual and associated with patient fatality. However, assertive thrombus aspiration and antiplatelet therapy could be effective in STEMI patients with multiple distal coronary artery occlusions

    Isolation, Screening and Identification of Swine Gut Microbiota with Ochratoxin A Biodegradation Ability

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    The potential for ochratoxin A (OTA) degradation by swine intestinal microbiota was assessed in the current study. Intestinal content that was collected aseptically from swine was spiked with 100 ppb OTA and incubated for 6 and 12 h at 39°C. An OTA assay was conducted using the incubated samples, and it was found that 20% of the OTA toxin was detoxified, indicating the presence of microbes capable of OTA degradation. Twenty-eight bacterial species were isolated anaerobically in M 98-5 media and 45 bacterial species were isolated using nutrient broth aerobically. Screening results showed that one anaerobic bacterial isolate, named MM11, detoxified more than 75% of OTA in liquid media. Furthermore, 1.0 ppm OTA was degraded completely after 24 h incubation on a solid ‘corn’ substrate. The bacterium was identified by 16S rDNA sequencing as having 97% sequence similarity with Eubacterium biforme. The isolation of an OTA-degrading bacterium from the swine natural flora is of great importance for OTA biodegradation and may be a valuable potential source for OTA-degradation enzymes in industrial applications

    Application of self-assembly peptides targeting the mitochondria as a novel treatment for sorafenib-resistant hepatocellular carcinoma cells

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    Currently, there is no appropriate treatment option for patients with sorafenib-resistant hepatocellular carcinoma (HCC). Meanwhile, pronounced anticancer activities of newly-developed mitochondria-accumulating self-assembly peptides (Mito-FF) have been demonstrated. This study intended to determine the anticancer effects of Mito-FF against sorafenib-resistant Huh7 (Huh7-R) cells. Compared to sorafenib, Mito-FF led to the generation of relatively higher amounts of mitochondrial reactive oxygen species (ROS) as well as the greater reduction in the expression of antioxidant enzymes (P &lt; 0.05). Mito-FF was found to significantly promote cell apoptosis while inhibiting cell proliferation of Huh7-R cells. Mito-FF also reduces the expression of antioxidant enzymes while significantly increasing mitochondrial ROS in Huh7-R cells. The pro-apoptotic effect of Mito-FFs for Huh7-R cells is possibly caused by their up-regulation of mitochondrial ROS, which is caused by the destruction of the mitochondria of HCC cells
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