Bio-expert : Knowledge Management Platform and Experiment for Bio-Medical e-Learning

Colloque avec actes et comité de lecture. internationale.International audiencebio-expert project has been launched to cover user needs in terms of access to high level knowledge content with a user friendly interface tool. The problematic raised here concerns not only imaging technologies, knowledge management system and interfaces but also the organisation of the content allowing an easy access of the repository to the community of biologists

À chacun son patrimoine ou patrimoine commun ?

Peu utilisée dans les programmes interdisciplinaires sur les rapports homme-nature analysés ici, la notion de patrimoine qui appartient à l’origine au vocabulaire juridique a été reprise par la sociologie, l’économie et par les naturalistes et parmi ces derniers, principalement par les écologues. Cette propagation d’une discipline à l’autre a donné naissance à la notion de patrimoine naturel, qui sert de point de départ pour une démarche interdisciplinaire. 1. Une notion de droit aux usages m..

Bio-expert : Knowledge Management Platform and Experiment for Bio-Medical e-Learning

Colloque avec actes et comité de lecture. internationale.International audiencebio-expert project has been launched to cover user needs in terms of access to high level knowledge content with a user friendly interface tool. The problematic raised here concerns not only imaging technologies, knowledge management system and interfaces but also the organisation of the content allowing an easy access of the repository to the community of biologists

A possible role of collagen fibrils in the process of calcification observed in the capsule of the pineal gland in aging rats

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Histamine H3 and dopamine D2 receptor-mediated [35S]GTPγ[S] binding in rat striatum: Evidence for additive effects but lack of interactions

International audienceThe interactions in the rat striatum between H3 receptors (H3Rs) and D2 receptors (D2Rs) were investigated with the [35S]GTPγ[S] binding assay. The H3R agonist (R)α-methylhistamine increased [35S]GTPγ[S] binding to striatal membranes with an EC50 = 14 ± 5 nM and a maximal effect of +19 ± 1%. This effect was inhibited by the H3R antagonist ciproxifan with a Ki = 1.0 ± 0.3 nM. The D2R agonist quinpirole increased [35S]GTPγ[S] binding to the same membranes with an EC50 = 1.5 ± 0.5 μM and a maximal effect of +28 ± 2%. Its effect was blocked by haloperidol with a Ki = 0.3 ± 0.1 nM. The maximal effects of the H3R and D2R agonists were additive (+46 ± 3%). However, D2R ligands did not modify the effects of H3R ligands and vice versa. Ciproxifan behaved as an H3R inverse agonist and decreased [35S]GTPγ[S] binding. Haloperidol had no effect and did not change the inverse agonist effect of ciproxifan. Administrations for 10 days of ciproxifan (1.5 mg/kg/day) or haloperidol (0.5 mg/kg/day) did not change the effects of quinpirole and (R)α-methylhistamine, respectively. These data suggest that striatal H3Rs and D2Rs do not interact through their coupling to G-proteins. However, a hyperactivity of histaminergic and dopaminergic neurons being observed in schizophrenia, the additive activations of H3Rs and D2Rs suggest that they cooperate to generate some schizophrenic symptoms. Such a postsynaptic mechanism may underlie the antipsychotic-like effects of H3R inverse agonists and supports their therapeutic interest, alone or as adjunctive treatment with neuroleptics

Postures des scientifiques et interdisciplinarité dans le champ de l'environnement

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