Durchführung von Gesundheitszirkeln an Krankenhäusern zur Verbesserung von Arbeitsbedingungen im Bereich Pflege

Das vorliegende Konzeptpapier beschreibt die Weiterentwicklung und Durchführung von Gesundheitszirkeln im Setting Krankenhaus und dient als Leitfaden zur Übertragung dieses Konzepts in weitere Kliniken. Die einzelnen Schritte der Umsetzung werden systematisch dargestellt und durch konkrete Erfahrungen am Universitätsklinikum Heidelberg ergänzt

Toward a methodical framework for comprehensively assessing forest multifunctionality

Biodiversity-ecosystem functioning (BEF) research has extended its scope from communities that are short-lived or reshape their structure annually to structurally complex forest ecosystems. The establishment of tree diversity experiments poses specific methodological challenges for assessing the multiple functions provided by forest ecosystems. In particular, methodological inconsistencies and nonstandardized protocols impede the analysis of multifunctionality within, and comparability across the increasing number of tree diversity experiments. By providing an overview on key methods currently applied in one of the largest forest biodiversity experiments, we show how methods differing in scale and simplicity can be combined to retrieve consistent data allowing novel insights into forest ecosystem functioning. Furthermore, we discuss and develop recommendations for the integration and transferability of diverse methodical approaches to present and future forest biodiversity experiments. We identified four principles that should guide basic decisions concerning method selection for tree diversity experiments and forest BEF research: (1) method selection should be directed toward maximizing data density to increase the number of measured variables in each plot. (2) Methods should cover all relevant scales of the experiment to consider scale dependencies of biodiversity effects. (3) The same variable should be evaluated with the same method across space and time for adequate larger-scale and longer-time data analysis and to reduce errors due to changing measurement protocols. (4) Standardized, practical and rapid methods for assessing biodiversity and ecosystem functions should be promoted to increase comparability among forest BEF experiments. We demonstrate that currently available methods provide us with a sophisticated toolbox to improve a synergistic understanding of forest multifunctionality. However, these methods require further adjustment to the specific requirements of structurally complex and long-lived forest ecosystems. By applying methods connecting relevant scales, trophic levels, and above? and belowground ecosystem compartments, knowledge gain from large tree diversity experiments can be optimized

The ABC130 barrel module prototyping programme for the ATLAS strip tracker

For the Phase-II Upgrade of the ATLAS Detector, its Inner Detector, consisting of silicon pixel, silicon strip and transition radiation sub-detectors, will be replaced with an all new 100 % silicon tracker, composed of a pixel tracker at inner radii and a strip tracker at outer radii. The future ATLAS strip tracker will include 11,000 silicon sensor modules in the central region (barrel) and 7,000 modules in the forward region (end-caps), which are foreseen to be constructed over a period of 3.5 years. The construction of each module consists of a series of assembly and quality control steps, which were engineered to be identical for all production sites. In order to develop the tooling and procedures for assembly and testing of these modules, two series of major prototyping programs were conducted: an early program using readout chips designed using a 250 nm fabrication process (ABCN-25) and a subsequent program using a follow-up chip set made using 130 nm processing (ABC130 and HCC130 chips). This second generation of readout chips was used for an extensive prototyping program that produced around 100 barrel-type modules and contributed significantly to the development of the final module layout. This paper gives an overview of the components used in ABC130 barrel modules, their assembly procedure and findings resulting from their tests.Comment: 82 pages, 66 figure

Role of Cytokinins in Senescence, Antioxidant Defence and Photosynthesis

Cytokinins modulate a number of important developmental processes, including the last phase of leaf development, known as senescence, which is associated with chlorophyll breakdown, photosynthetic apparatus disintegration and oxidative damage. There is ample evidence that cytokinins can slow down all these senescence-accompanying changes. Here, we review relationships between the various mechanisms of action of these regulatory molecules. We highlight their connection to photosynthesis, the pivotal process that generates assimilates, however may also lead to oxidative damage. Thus, we also focus on cytokinin induction of protective responses against oxidative damage. Activation of antioxidative enzymes in senescing tissues is described as well as changes in the levels of naturally occurring antioxidative compounds, such as phenolic acids and flavonoids, in plant explants. The main goal of this review is to show how the biological activities of cytokinins may be related to their chemical structure. New links between molecular aspects of natural cytokinins and their synthetic derivatives with antisenescent properties are described. Structural motifs in cytokinin molecules that may explain why these molecules play such a significant regulatory role are outlined

Design, synthesis and perception of fluorescently labeled isoprenoid cytokinins

Isoprenoid cytokinins play a number of crucial roles in the regulation of plant growth and development. To study cytokinin receptor properties in plants, we designed and prepared fluorescent derivatives of 6-[(3-methylbut-2-en-1-yl)amino]purine (N6-isopentenyladenine, iP) with several fluorescent labels attached to the C2 or N9 atom of the purine moiety via a 2- or 6-carbon linker. The fluorescent labels included dansyl (DS), fluorescein (FC), 7-nitrobenzofurazan (NBD), rhodamine B (RhoB), coumarin (Cou), 7-(diethylamino)coumarin (DEAC) and cyanine 5 dye (Cy5). All prepared compounds were screened for affinity for the Arabidopsis thaliana cytokinin receptor (CRE1/AHK4). Although the attachment of the fluorescent labels to iP via the linkers mostly disrupted binding to the receptor, several fluorescent derivatives interacted well. For this reason, three derivatives, two rhodamine B and one 4-chloro-7-nitrobenzofurazan labeled iP were tested for their interaction with CRE1/AHK4 and Zea mays cytokinin receptors in detail. We further showed that the three derivatives were able to activate transcription of cytokinin response regulator ARR5 in Arabidopsis seedlings. The activity of fluorescently labeled cytokinins was compared with corresponding 6-dimethylaminopurine fluorescently labeled negative controls. Selected rhodamine B C2-labeled compounds 17, 18 and 4-chloro-7-nitrobenzofurazan N9-labeled compound 28 and their respective negative controls (19, 20 and 29, respectively) were used for in planta staining experiments in Arabidopsis thaliana cell suspension culture using live cell confocal microscopy

Toward a methodical framework for comprehensively assessing forest multifunctionality

Biodiversity-ecosystem functioning (BEF) research has extended its scope from communities that are short-lived or reshape their structure annually to structurally complex forest ecosystems. The establishment of tree diversity experiments poses specific methodological challenges for assessing the multiple functions provided by forest ecosystems. In particular, methodological inconsistencies and nonstandardized protocols impede the analysis of multifunctionality within, and comparability across the increasing number of tree diversity experiments. By providing an overview on key methods currently applied in one of the largest forest biodiversity experiments, we show how methods differing in scale and simplicity can be combined to retrieve consistent data allowing novel insights into forest ecosystem functioning. Furthermore, we discuss and develop recommendations for the integration and transferability of diverse methodical approaches to present and future forest biodiversity experiments. We identified four principles that should guide basic decisions concerning method selection for tree diversity experiments and forest BEF research: (1) method selection should be directed toward maximizing data density to increase the number of measured variables in each plot. (2) Methods should cover all relevant scales of the experiment to consider scale dependencies of biodiversity effects. (3) The same variable should be evaluated with the same method across space and time for adequate larger-scale and longer-time data analysis and to reduce errors due to changing measurement protocols. (4) Standardized, practical and rapid methods for assessing biodiversity and ecosystem functions should be promoted to increase comparability among forest BEF experiments. We demonstrate that currently available methods provide us with a sophisticated toolbox to improve a synergistic understanding of forest multifunctionality. However, these methods require further adjustment to the specific requirements of structurally complex and long-lived forest ecosystems. By applying methods connecting relevant scales, trophic levels, and above- and belowground ecosystem compartments, knowledge gain from large tree diversity experiments can be optimized

Kompetenzzentrum Denkmalwissenschaften und Denkmaltechnologien 2016-2018

Das Kompetenzzentrum Denkmalwissenschaften und Denkmaltechnologien (KDWT) wurde als zentrale Forschungseinrichtung der Otto-Friedrich-Universität Bamberg im Frühjahr 2016 gegründet. Die Kernaufgaben des KDWT bestehen im Ausbau des Wissens- und Technologietransfers zu außeruniversitären Forschungseinrichtungen, zur Wirtschaft und zum Handwerk, im Ausbau der technischen Kompetenz, in der Ergänzung des Lehrangebots, in der inhaltlichen und technisch apparativen Unterstützung in Forschung, Lehre, Transfer und Dienstleistung sowie in der Internationalisierung der Forschung. Das Zentrum gliedert sich in vier Arbeitsbereiche: Denkmalpflege, Digitale Denkmaltechnologien, Bauforschung und Restaurierungswissenschaft und deckt damit sowohl das geisteswissenschaftliche Fundament wie auch ingenieurs- und naturwissenschaftliche Herangehensweisen gleichermaßen ab. Mit dem ersten Band der Reihe „Berichte des KDWT“ wird die fachlich vielfältige Tätigkeit der ersten zweieinhalb Jahre seit dem Bestehen des Kompetenzzentrums in farbig illustrierter Form vorgelegt. Vier Hauptkapitel repräsentieren entsprechend die vier erwähnten Arbeitsbereiche. Zunächst werden die grundlegenden Ziele und Profilierungsschwerpunkte eines jeden Faches geschildert. Darauf folgen Einzeldarstellungen der jeweiligen Forschungsvorhaben, die vor allem durch beigestellte Abbildungen die Inhalte auch dem nicht fachkundigen Leser nahebringen möchten. Zur besseren Übersicht sind den Projekten Basisinformationen und thematisch verknüpfte Publikationen hinzugefügt. So berichtet der Arbeitsbereich Denkmalpflege über verschiedene Projekte rund um das Thema Stadt und Denkmalpflege, beschäftigt sich mit partizipativem Erbeschutz, Emotionen und Erbe sowie einem kommunalen Denkmalkonzept für Bayern, um nur einige zu nennen. Die Digitalen Denkmaltechnologien erläutern Vorhaben im Bereich der 3D-Dokumentation. Der Arbeitsbereich Bauforschung analysiert mittelalterliche Großbauten, erarbeitet Konzepte zum Bauerhalt und verbessert die technische Kompetenz in der Bauwerksanalyse. Und schließlich erläutert der Bereich Restaurierungswissenschaft den Einsatz von zerstörungsfreien Untersuchungsmethoden und der Mikroanalytik anhand von internationalen wie lokalen Vorhaben, seien es nun singhalesische Tempelanlagen, europäische Kathedralen oder mittelalterliche Textilien aus dem Bamberger Domschatz. Die Projektdarstellungen möchten verdeutlichen, inwiefern jedes Teilgebiet das Kompetenzzentrum mit außerordentlicher, fachlich fundierter Erfahrung und Expertise in der Lehre, in der Forschung und vor allem in der Praxis vertritt. Um ferner den umfänglichen Transfer-, Vernetzungs- und Forschungstätigkeiten der einzelnen Mitglieder gerecht zu werden, sind in einem fünften Hauptkapitel alle Einzelleistungen bis Mitte 2018 in alphabetisch sortierten Listen aufgeführt