Tall height and obesity are associated with an increased risk of aggressive prostate cancer: results from the EPIC cohort study.

BACKGROUND: The relationship between body size and prostate cancer risk, and in particular risk by tumour characteristics, is not clear because most studies have not differentiated between high-grade or advanced stage tumours, but rather have assessed risk with a combined category of aggressive disease. We investigated the association of height and adiposity with incidence of and death from prostate cancer in 141,896 men in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. METHODS: Multivariable-adjusted Cox proportional hazards models were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs). After an average of 13.9 years of follow-up, there were 7024 incident prostate cancers and 934 prostate cancer deaths. RESULTS: Height was not associated with total prostate cancer risk. Subgroup analyses showed heterogeneity in the association with height by tumour grade (P heterogeneity = 0.002), with a positive association with risk for high-grade but not low-intermediate-grade disease (HR for high-grade disease tallest versus shortest fifth of height, 1.54; 95% CI, 1.18-2.03). Greater height was also associated with a higher risk for prostate cancer death (HR = 1.43, 1.14-1.80). Body mass index (BMI) was significantly inversely associated with total prostate cancer, but there was evidence of heterogeneity by tumour grade (P heterogeneity = 0.01; HR = 0.89, 0.79-0.99 for low-intermediate grade and HR = 1.32, 1.01-1.72 for high-grade prostate cancer) and stage (P heterogeneity = 0.01; HR = 0.86, 0.75-0.99 for localised stage and HR = 1.11, 0.92-1.33 for advanced stage). BMI was positively associated with prostate cancer death (HR = 1.35, 1.09-1.68). The results for waist circumference were generally similar to those for BMI, but the associations were slightly stronger for high-grade (HR = 1.43, 1.07-1.92) and fatal prostate cancer (HR = 1.55, 1.23-1.96). CONCLUSIONS: The findings from this large prospective study show that men who are taller and who have greater adiposity have an elevated risk of high-grade prostate cancer and prostate cancer death

Unique competence requirements of the board : A study on competence changes within the board

Background: The board of directors is a key player in corporate governance. Their role is to ensure that the corporations are run with the interest of the shareholders as the main focus. In the beginning of the 21st century, a survey was made about the confidence of the Swedish business community and in which criticism was directed to the board of directors. The boards were deemed inadequate in their function and were often solely composed by members with similar experiences and competence, therefore lacking in diversity. In order to improve the competence and work of the board of directors, the Swedish code of corporate governance was introduced and its recommendations comprehend the boards’ size and composition. The recommendations are based on “comply or explain” and are therefore not enforced. It is, thus, possible to question the extent to which the recommendations are adhered to and whether the code’s introduction has affected the composition of the boards of directors and, consequently, their competence. Aim: This master thesis aims to explain the board composition of Swedish company boards during the years 1999, 2008 and 2011 and to analyze how this composition differs between the years. By studying the factors that are the basis of the composition, we also intend to discuss if, there has been a change of competence on the company boards. Completion: This thesis is of qualitative nature and its main focus is based on an analytical model that has been composed out of laws, regulation and theories. The analytical model has been the starting point for the gathering of information as well as for the analysis of the information. The empirical material is based on a study of annual reports and reports on corporate governance in ten companies as well as interviews with three members of nomination committees. Results: The thesis identifies several competence factors whose relevance varies according to the regulations or theory you take into consideration. The nomination committee's views on competence covers most of these factors. The thesis shows that the information available to shareholders does not completely capture the nomination committee’s view on competence. Furthermore, the thesis finds that the competencies of the board of directors are due to the unique company and its specific situation and an argumentation over whether a change incompetence has occurred can thus not be made without taking this into consideration

Cormac McCarthy's „No Country for Old Men”: - Narative Elements in Film and Novel

Šis maģistra darbs, "Kormaka Makārteja „Kur sirmgalvjiem nav vietas " – naratīva elementi filmā un romānā" ir koncentrēts uz filmas adaptācijas „Kur sirmgalvjiem nav vietas" naratīva un Kormaka Makārtija literarārā pirmavota teksta ar tādu pašu nosaukumu literārā naratīva salīdzinājumu. Darba mērķis ir atainot abu tekstu līdzības un atšķirības un pierādīt, ka filma ievērojami atšķiras ar izdomu un stāstījuma veidu. Teorētiskajā daļā ir sniegts izskaidrojums tādiem konceptiem, kā naratīvs, laiks un telpa, Bahtina hronotops, naratīva perspektīva, fokalizācija un vesterna žanrs, kas ir svarīgi elementi filmas un literārā teksta naratīvu attiecību izpētē. Darba rezultāts apstiprina maģistra darba hipotēzi un pierāda, ka filmas naratīvs ievērojami atšķiras ar izdomu un stāstījuma veidu, kas arī spēlē svarīgu lomu abu stāstu varoņu likteņos. Atslēgvārdi: naratīvs, laiks un telpa, Bakhtina hronotops, vesterna žanrsThe present master thesis, ‘Cormac McCarthy’s No Country for Old Men – Narative Elements in Film and Novel’, focuses on the comparision of the narrative in the adapted film No Country for Old Men and the literary narrative in the source text by Cormac McCarthy bearing the same tite. Its purpose is to demonstrate various distinctions and similarities of both texts and to prove that the film significantly differs in inventiveness and the style of rendering the story. The theoretical part explains the concepts of narrative, time and space, Bakhtin’ s chronotope, narrative perspective, focalization and the western genre that are essential elements in the analysis of the relationship between the film and the literary fiction narratives. The results confirm the hypothesis of the thesis and demonstrate that the film narrative significantly differs in inventiveness and style the story is rendered, which also plays an important role in the fates of the characters in both stories

Blood pressure and risk of cancer in the European Prospective Investigation into Cancer and Nutrition.

Several studies have reported associations of hypertension with cancer, but not all results were conclusive. We examined the association of systolic (SBP) and diastolic (DBP) blood pressure with the development of incident cancer at all anatomical sites in the European Prospective Investigation into Cancer and Nutrition (EPIC). Hazard ratios (HRs) (95% confidence intervals) were estimated using multivariable Cox proportional hazards models, stratified by EPIC-participating center and age at recruitment, and adjusted for sex, education, smoking, body mass index, physical activity, diabetes and dietary (in women also reproductive) factors. The study included 307,318 men and women, with an average follow-up of 13.7 (standard deviation 4.4) years and 39,298 incident cancers. We confirmed the expected positive association with renal cell carcinoma: HR = 1.12 (1.08-1.17) per 10 mm Hg higher SBP and HR = 1.23 (1.14-1.32) for DBP. We additionally found positive associations for esophageal squamous cell carcinoma (SCC): HR = 1.16 (1.07-1.26) (SBP), HR = 1.31 (1.13-1.51) (DBP), weaker for head and neck cancers: HR = 1.08 (1.04-1.12) (SBP), HR = 1.09 (1.01-1.17) (DBP) and, similarly, for skin SCC, colon cancer, postmenopausal breast cancer and uterine adenocarcinoma (AC), but not for esophageal AC, lung SCC, lung AC or uterine endometroid cancer. We observed weak inverse associations of SBP with cervical SCC: HR = 0.91 (0.82-1.00) and lymphomas: HR = 0.97 (0.93-1.00). There were no consistent associations with cancers in other locations. Our results are largely compatible with published studies and support weak associations of blood pressure with cancers in specific locations and morphologies

Tall height and obesity are associated with an increased risk of aggressive prostate cancer: results from the EPIC cohort study

Background: The relationship between body size and prostate cancer risk, and in particular risk by tumour characteristics, is not clear because most studies have not differentiated between high-grade or advanced stage tumours, but rather have assessed risk with a combined category of aggressive disease. We investigated the association of height and adiposity with incidence of and death from prostate cancer in 141,896 men in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods: Multivariable-adjusted Cox proportional hazards models were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs). After an average of 13.9 years of follow-up, there were 7024 incident prostate cancers and 934 prostate cancer deaths. Results: Height was not associated with total prostate cancer risk. Subgroup analyses showed heterogeneity in the association with height by tumour grade (P-heterogeneity = 0.002), with a positive association with risk for high-grade but not low-intermediate-grade disease (HR for high-grade disease tallest versus shortest fifth of height, 1.54; 95% CI, 1.18-2.03). Greater height was also associated with a higher risk for prostate cancer death (HR = 1.43, 1.14-1.80). Body mass index (BMI) was significantly inversely associated with total prostate cancer, but there was evidence of heterogeneity by tumour grade (P-heterogeneity = 0.01; HR = 0.89, 0.79-0.99 for low-intermediate grade and HR = 1.32, 1.01-1.72 for high-grade prostate cancer) and stage (P-heterogeneity = 0.01; HR = 0.86, 0.75-0.99 for localised stage and HR = 1.11, 0.92-1.33 for advanced stage). BMI was positively associated with prostate cancer death (HR = 1.35, 1.09-1.68). The results for waist circumference were generally similar to those for BMI, but the associations were slightly stronger for high-grade (HR = 1.43, 1.07-1.92) and fatal prostate cancer (HR = 1.55, 1.23-1.96). Conclusions: The findings from this large prospective study show that men who are taller and who have greater adiposity have an elevated risk of high-grade prostate cancer and prostate cancer death