11 research outputs found

    Bariatric operation in treatment of morbidian obesity and metabolic syndrome (revier of literature)

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    Morbid obesity, associated with various metabolic disorders leading to a decrease in the quality of life and its duration. Conservative treatment of morbid obesity is often ineffective, and therefore bariatric surgery is becoming more common. The review analyzed clinical recommendations and our experience in selecting patients for bariatric surgery, assessed the effectiveness and safety of various types of operations, and outlined the main problems of these operational benefits.ΠœΠΎΡ€Π±ΠΈΠ΄Π½ΠΎΠ΅ ΠΎΠΆΠΈΡ€Π΅Π½ΠΈΠ΅, ассоциировано с Ρ€Π°Π·Π»ΠΈΡ‡Π½Ρ‹ΠΌΠΈ мСтаболичСскими Π½Π°Ρ€ΡƒΡˆΠ΅Π½ΠΈΡΠΌΠΈ приводящими ΠΊ сниТСнию качСства ΠΆΠΈΠ·Π½ΠΈ ΠΈ Π΅Π΅ ΠΏΡ€ΠΎΠ΄ΠΎΠ»ΠΆΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎΡΡ‚ΠΈ. консСрвативныС ΠΌΠ΅Ρ‚ΠΎΠ΄Ρ‹ лСчСния ΠΌΠΎΡ€Π±ΠΈΠ΄Π½ΠΎΠ³ΠΎ оТирСния Π½Π΅Ρ€Π΅Π΄ΠΊΠΎ ΠΎΠΊΠ°Π·Ρ‹Π²Π°ΡŽΡ‚ΡΡ нСэффСктивными, Π² связи с Ρ‡Π΅ΠΌ, бариатричСская хирургия ΠΏΠΎΠ»ΡƒΡ‡ΠΈΠ»Π° ΡˆΠΈΡ€ΠΎΠΊΠΎΠ΅ распространСниС. Π’ ΠΎΠ±Π·ΠΎΡ€Π΅ ΠΏΡ€ΠΎΠ°Π½Π°Π»ΠΈΠ·ΠΈΡ€ΠΎΠ²Π°Π½Ρ‹ клиничСскиС Ρ€Π΅ΠΊΠΎΠΌΠ΅Π½Π΄Π°Ρ†ΠΈΠΈ ΠΈ наш ΠΎΠΏΡ‹Ρ‚ ΠΏΠΎ ΠΎΡ‚Π±ΠΎΡ€Ρƒ ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² Π½Π° бариатричСскиС ΠΎΠΏΠ΅Ρ€Π°Ρ†ΠΈΠΈ, ΠΏΡ€ΠΎΠ²Π΅Π΄Π΅Π½Π° ΠΎΡ†Π΅Π½ΠΊΠ° эффСктивности ΠΈ бСзопасности Ρ€Π°Π·Π»ΠΈΡ‡Π½Ρ‹Ρ… Π²ΠΈΠ΄ΠΎΠ² ΠΎΠΏΠ΅Ρ€Π°Ρ†ΠΈΠΉ ΠΈ ΠΎΠ±ΠΎΠ·Π½Π°Ρ‡Π΅Π½Ρ‹ основныС ΠΏΡ€ΠΎΠ±Π»Π΅ΠΌΡ‹ Π΄Π°Π½Π½Ρ‹Ρ… ΠΎΠΏΠ΅Ρ€Π°Ρ‚ΠΈΠ²Π½Ρ‹Ρ… пособий

    White Paper: Designing the perfect New European Bauhaus neighbourhood

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    The concept of Smart Healthy Age-Friendly Environments (SHAFE) emphasises the comprehensive person-centred experience as essential to promoting living environments. SHAFE takes an interdisciplinary approach, conceptualising complete and multidisciplinary solutions for an inclusive society. From this approach, we promote participation, health, and well-being experiences by finding the best possible combinations of social, physical, and digital solutions in the community. This initiative emerged bottom-up in Europe from the dream and conviction that innovation can improve health equity, foster caring communities, and sustainable development. Smart, adaptable, and inclusive solutions can promote and support independence and autonomy throughout the lifespan, regardless of age, gender, disabilities, cultural differences, and personal choices, as well as promote happier and fairer living places. The New European Bauhaus initiative gathers "beautiful, sustainable, and inclusive projects and ideas" to inspire a positive transformation around us. The New European Bauhaus 2024 Festival took place between 9-13 April. "Designing the perfect New European Bauhaus neighbourhood: New European Bauhaus meets SHAFE" was a Satellite Event of the Festival, held as an online workshop, organised by the SHAFE Foundation on April 9th, 2024. At the event, a group of 50 participants with a multidisciplinary background discussed how to meet the challenges of the European Garcia family to enable them to live in a perfect neighbourhood. The White Paper presents the findings of the participants with the New European Bauhaus inspiring projects and ideas to house the European Garcia family in their neighbourhood. The White Paper recommends developers, designers, planners, and policymakers to include person-centred design of social and physical environments and technologies. Although awareness of person-centred design is growing, many initiatives still hamper the inclusion of citizens or end-users throughout the development of products and services

    White Paper: Designing the perfect New European Bauhaus neighbourhood

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    The concept of Smart Healthy Age-Friendly Environments (SHAFE) emphasises the comprehensive person-centred experience as essential to promoting living environments. SHAFE takes an interdisciplinary approach, conceptualising complete and multidisciplinary solutions for an inclusive society. From this approach, we promote participation, health, and well-being experiences by finding the best possible combinations of social, physical, and digital solutions in the community. This initiative emerged bottom-up in Europe from the dream and conviction that innovation can improve health equity, foster caring communities, and sustainable development. Smart, adaptable, and inclusive solutions can promote and support independence and autonomy throughout the lifespan, regardless of age, gender, disabilities, cultural differences, and personal choices, as well as promote happier and fairer living places. The New European Bauhaus initiative gathers β€œbeautiful, sustainable, and inclusive projects and ideas” to inspire a positive transformation around us. The New European Bauhaus 2024 Festival took place between 9-13 April. β€œDesigning the perfect New European Bauhaus neighbourhood: New European Bauhaus meets SHAFE” was a Satellite Event of the Festival, held as an online workshop, organised by the SHAFE Foundation on April 9th, 2024

    Π’ΠΏΠ»ΠΈΠ² бронСзахисту Π½Π° Ρ‚Π°ΠΊΡ‚ΠΈΠΊΠΎ-Ρ‚Π΅Ρ…Π½Ρ–Ρ‡Π½Ρ– характСристики Π°Ρ€ΠΌΡ–ΠΉΡΡŒΠΊΠΈΡ… Π°Π²Ρ‚ΠΎΠΌΠΎΠ±Ρ–Π»Ρ–Π² Π±Π°Π³Π°Ρ‚ΠΎΡ†Ρ–Π»ΡŒΠΎΠ²ΠΎΠ³ΠΎ призначСння

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    In this article analyzes the impact of armoured protection on the main technical characteristics army multipurpose vehicles, comparative analysis of advanced models and existing types of military vehicles, formed subsequent directions of research to evaluate changes of technical characteristics when installed armored protection on basic models army multipurpose vehicles.Π’ Ρ€Π°Π±ΠΎΡ‚Π΅ ΠΏΡ€ΠΎΠ°Π½Π°Π»ΠΈΠ·ΠΈΡ€ΠΎΠ²Π°Π½ΠΎ влияниС Π±Ρ€ΠΎΠ½Π΅Π·Π°Ρ‰ΠΈΡ‚Ρ‹ Π½Π° основныС Ρ‚Π°ΠΊΡ‚ΠΈΠΊΠΎ-тСхничСскиС характСристики(Π’Π’Π₯) армСйских Π°Π²Ρ‚ΠΎΠΌΠΎΠ±ΠΈΠ»Π΅ΠΉ ΠΌΠ½ΠΎΠ³ΠΎΡ†Π΅Π»Π΅Π²ΠΎΠ³ΠΎ назначСния(ААМН), ΠΏΡ€ΠΎΠ²Π΅Π΄Π΅Π½ ΡΡ€Π°Π²Π½ΠΈΡ‚Π΅Π»ΡŒΠ½Ρ‹ΠΉ Π°Π½Π°Π»ΠΈΠ· Π’Π’Π₯ пСрспСктивных ΠΎΠ±Ρ€Π°Π·Ρ†ΠΎΠ² ΠΈ ΡΡƒΡ‰Π΅ΡΡ‚Π²ΡƒΡŽΡ‰ΠΈΡ… Ρ‚ΠΈΠΏΠΎΠ² Π²ΠΎΠ΅Π½Π½ΠΎΠΉ Π°Π²Ρ‚ΠΎΠΌΠΎΠ±ΠΈΠ»ΡŒΠ½ΠΎΠΉ Ρ‚Π΅Ρ…Π½ΠΈΠΊΠΈ, сформулировано дальнСйшСС Π½Π°ΠΏΡ€Π°Π²Π»Π΅Π½ΠΈΠ΅ исслСдований ΠΏΠΎ ΠΎΡ†Π΅Π½ΠΊΠ΅ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΉ Π’Π’Π₯ ΠΏΡ€ΠΈ установкС Π±Ρ€ΠΎΠ½ΠΈΡ€ΠΎΠ²Π°Π½Π½ΠΎΠΉ Π·Π°Ρ‰ΠΈΡ‚Ρ‹ Π½Π° Π±Π°Π·ΠΎΠ²Ρ‹Π΅ ΠΌΠΎΠ΄Π΅Π»ΠΈ ААМН.Π£ Ρ€ΠΎΠ±ΠΎΡ‚Ρ– ΠΏΡ€ΠΎΠ°Π½Π°Π»Ρ–Π·ΠΎΠ²Π°Π½ΠΎ Π²ΠΏΠ»ΠΈΠ² бронСзахисту Π½Π° основні Ρ‚Π°ΠΊΡ‚ΠΈΠΊΠΎ-Ρ‚Π΅Ρ…Π½Ρ–Ρ‡Π½Ρ– характСристики (Π’Π’Π₯) Π°Ρ€ΠΌΡ–ΠΉΡΡŒΠΊΠΈΡ… Π°Π²Ρ‚ΠΎΠΌΠΎΠ±Ρ–Π»Ρ–Π² Π±Π°Π³Π°Ρ‚ΠΎΡ†Ρ–Π»ΡŒΠΎΠ²ΠΎΠ³ΠΎ призначСння (ΠΠΠ‘ΠŸ), ΠΏΡ€ΠΎΠ²Π΅Π΄Π΅Π½ΠΎ ΠΏΠΎΡ€Ρ–Π²Π½ΡΠ»ΡŒΠ½ΠΈΠΉ Π°Π½Π°Π»Ρ–Π· Π’Π’Π₯ пСрспСктивних Π·Ρ€Π°Π·ΠΊΡ–Π² Ρ‚Π° Ρ–ΡΠ½ΡƒΡŽΡ‡ΠΈΡ… Ρ‚ΠΈΠΏΡ–Π² Π²Ρ–ΠΉΡΡŒΠΊΠΎΠ²ΠΎΡ— Π°Π²Ρ‚ΠΎΠΌΠΎΠ±Ρ–Π»ΡŒΠ½ΠΎΡ— Ρ‚Π΅Ρ…Π½Ρ–ΠΊΠΈ, сформовано ΠΏΠΎΠ΄Π°Π»ΡŒΡˆΡ– напрямки Π΄ΠΎΡΠ»Ρ–Π΄ΠΆΠ΅Π½ΡŒ Ρ‰ΠΎΠ΄ΠΎ ΠΎΡ†Ρ–Π½ΠΊΠΈ Π·ΠΌΡ–Π½ΠΈ Π’Π’Π₯ ΠΏΡ€ΠΈ встановлСнні Π±Ρ€ΠΎΠ½ΡŒΠΎΠ²Π°Π½ΠΎΠ³ΠΎ захисту Π½Π° Π±Π°Π·ΠΎΠ²Ρ– ΠΌΠΎΠ΄Π΅Π»Ρ– ΠΠΠ‘ΠŸ

    Analysis of cold ring rolling process

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    ΠŸΠ°Ρ€Π²ΠΎΠ²Ρ–Ρ€ΡƒΡ Π²19-вірСмія. ΠΊΠ»Ρ–Π½Ρ–ΠΊΠΎ-Π»Π°Π±ΠΎΡ€Π°Ρ‚ΠΎΡ€Π½Π° прСзСнтація

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    Parvovirus B19 (PVB19), (formerly erythrovirus B19) is the etiological agent of the so-called Β«Fifth diseaseΒ», which is mainly found in childhood and adoles-cence, but is also associated with polymorphic clinical presentation, aplastic crises, hemolytic anemia, thrombocytopenia etc., and in pregnant women β€” unauthorized abortions.Clinical case.Β Reported a case of PVB19 viremia, which in a 2-year-old patient was the cause of systemic damage. Attention is focused on the long-term differential diagnosis of exanthema in combination with hepatosplenomegaly, polyserositis and leukopenia with neutropenia, anemia and thrombocytopenia of infectious and non-infectious origin, including excluded the neoplastic process, collagenosis. To verify the diagnosis, numerous microbiological tests, aspiration and trepanation bone marrow (BM) biopsy were performed, puncture of pleural fluid, skin biopsy, imaging methods were used: ultrasound (ultrasound), chest Π₯-ray, computed tomography. In Π’M, cytological and histological studies revealed giant erythroid cell elements in the pronormoblast stage with pronounced intranuclear inclusions with chromatin pressed to the periphery of the nucleus, which led to the suspicion of PVB19 infection, which was confirmed using the polymerase chain reaction method. Recovery of the child occurred after the use of methylprednisolone at a dose of 2.7 mg/kg for 28 days with a gradual withdrawal of the medication.Conclusions.Β In our opinion, this topic is relevant in the practice of doctors of various specialties, since the timeliness, adequacy and result of treatment depend on the correct verification of the clinical diagnosis.The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of all participating institution. The informed consent of the child's parents was obtained for the research.No conflict of interest was declared by the authors.ΠŸΠ°Ρ€Π²ΠΎΠ²ΠΈΡ€ΡƒΡ Π’19 (PVB19), ΠΏΡ€Π΅ΠΆΠ½Π΅Π΅ Π½Π°Π·Π²Π°Π½ΠΈΠ΅ эритровирус B19, являСтся этиологичСским Π°Π³Π΅Π½Ρ‚ΠΎΠΌ Ρ‚.Π½. «пятой Π±ΠΎΠ»Π΅Π·Π½ΠΈΒ», которая прСимущСствСнно встрСчаСтся Π² дСтском ΠΈ подростковом возрастС. Π’Π°ΠΊΠΆΠ΅ Π΅Π³ΠΎ ΡΠ²ΡΠ·Ρ‹Π²Π°ΡŽΡ‚ с ΠΏΠΎΠ»ΠΈΠΌΠΎΡ€Ρ„Π½ΠΎΠΉ клиничСской ΠΏΡ€Π΅Π·Π΅Π½Ρ‚Π°Ρ†ΠΈΠ΅ΠΉ, апластичСскими кризисами, гСмолитичСской Π°Π½Π΅ΠΌΠΈΠ΅ΠΉ, Ρ‚Ρ€ΠΎΠΌΠ±ΠΎΡ†ΠΈΡ‚ΠΎΠΏΠ΅Π½ΠΈΠ΅ΠΉ ΠΈ Ρ‚.Π΄., Π° Ρƒ Ρ€ΠΎΠΆΠ΅Π½ΠΈΡ† β€” с ΡΠ°ΠΌΠΎΠΏΡ€ΠΎΠΈΠ·Π²ΠΎΠ»ΡŒΠ½Ρ‹ΠΌΠΈ Π°Π±ΠΎΡ€Ρ‚Π°ΠΌΠΈ.ΠšΠ»ΠΈΠ½ΠΈΡ‡Π΅ΡΠΊΠΈΠΉ случай.Β ΠŸΡ€ΠΈΠ²Π΅Π΄Π΅Π½ΠΎ клиничСскоС наблюдСниС PVB19-Π²ΠΈΡ€Π΅ΠΌΠΈΠΈ, которая явилась ΠΏΡ€ΠΈΡ‡ΠΈΠ½ΠΎΠΉ систСмного пораТСния Ρƒ Π΄Π²ΡƒΡ…Π»Π΅Ρ‚Π½Π΅Π³ΠΎ ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚Π°. АкцСнтируСтся Π²Π½ΠΈΠΌΠ°Π½ΠΈΠ΅ Π½Π° Π΄Π»ΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎΠΉ Π΄ΠΈΡ„Ρ„Π΅Ρ€Π΅Π½Ρ†ΠΈΠ°Π»ΡŒΠ½ΠΎΠΉ диагностикС экзантСмы Π² сочСтании с гСпатосплСномСгалиСй, полисСрозитом ΠΈ Π»Π΅ΠΉΠΊΠΎΠΏΠ΅Π½ΠΈΠ΅ΠΉ с Π½Π΅ΠΉΡ‚Ρ€ΠΎΠΏΠ΅Π½ΠΈΠ΅ΠΉ, Π°Π½Π΅ΠΌΠΈΠ΅ΠΉ ΠΈ Ρ‚Ρ€ΠΎΠΌΠ±ΠΎΡ†ΠΈΡ‚ΠΎΠΏΠ΅Π½ΠΈΠ΅ΠΉ ΠΈΠ½Ρ„Π΅ΠΊΡ†ΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ ΠΈ Π½Π΅ΠΈΠ½Ρ„Π΅ΠΊΡ†ΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ Π³Π΅Π½Π΅Π·Π°, Π² Ρ‚. Ρ‡. ΠΈΡΠΊΠ»ΡŽΡ‡Π°Π»ΠΈΡΡŒ нСопластичСский процСсс, ΠΊΠΎΠ»Π°Π³Π΅Π½ΠΎΠ·. Для Π²Π΅Ρ€ΠΈΡ„ΠΈΠΊΠ°Ρ†ΠΈΠΈ Π΄ΠΈΠ°Π³Π½ΠΎΠ·Π° ΠΏΡ€ΠΈΠΌΠ΅Π½ΡΠ»ΠΈΡΡŒ многочислСнныС микробиологичСскиС тСсты, аспирационная ΠΈ трСпанационная биопсия костного ΠΌΠΎΠ·Π³Π° (КМ), пункция ΠΏΠ»Π΅Π²Ρ€Π°Π»ΡŒΠ½ΠΎΠΉ Тидкости, биопсия ΠΊΠΎΠΆΠΈ, Π° Ρ‚Π°ΠΊΠΆΠ΅ ΠΌΠ΅Ρ‚ΠΎΠ΄Ρ‹ Π²ΠΈΠ·ΡƒΠ°Π»ΠΈΠ·Π°Ρ†ΠΈΠΈ: ΡƒΠ»ΡŒΡ‚Ρ€Π°Π·Π²ΡƒΠΊΠΎΠ²ΠΎΠ΅ исслСдованиС, рСнтгСнография ΠΎΡ€Π³Π°Π½ΠΎΠ² Π³Ρ€ΡƒΠ΄Π½ΠΎΠΉ ΠΊΠ»Π΅Ρ‚ΠΊΠΈ, ΠΊΠΎΠΌΠΏΡŒΡŽΡ‚Π΅Ρ€Π½Π°Ρ томография. Π’ КМ ΠΏΡ€ΠΈ цитологичСском ΠΈ гистологичСском исслСдовании ΠΎΠ±Π½Π°Ρ€ΡƒΠΆΠ΅Π½Ρ‹ гигантскиС эритроидныС ΠΊΠ»Π΅Ρ‚ΠΎΡ‡Π½Ρ‹Π΅ элСмСнты Π² стадии пронормобласта с Π²Ρ‹Ρ€Π°ΠΆΠ΅Π½Π½Ρ‹ΠΌΠΈ внутриядСрными Π²ΠΊΠ»ΡŽΡ‡Π΅Π½ΠΈΡΠΌΠΈ с вытСснСниСм Ρ…Ρ€ΠΎΠΌΠ°Ρ‚ΠΈΠ½Π° ΠΊ ΠΏΠ΅Ρ€ΠΈΡ„Π΅Ρ€ΠΈΠΈ ядра, Ρ‡Ρ‚ΠΎ Π²Ρ‹Π·Π²Π°Π»ΠΎ ΠΏΠΎΠ΄ΠΎΠ·Ρ€Π΅Π½ΠΈΠ΅ ΠΎΡ‚Π½ΠΎΡΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎ PVB19-ΠΈΠ½Ρ„Π΅ΠΊΡ†ΠΈΠΈ, которая ΠΏΠΎΠ΄Ρ‚Π²Π΅Ρ€ΠΆΠ΅Π½Π° с ΠΏΠΎΠΌΠΎΡ‰ΡŒΡŽ ΠΌΠ΅Ρ‚ΠΎΠ΄Π° ΠΏΠΎΠ»ΠΈΠΌΠ΅Ρ€Π°Π·Π½ΠΎ-Ρ†Π΅ΠΏΠ½ΠΎΠΉ Ρ€Π΅Π°ΠΊΡ†ΠΈΠΈ. Π’Ρ‹Π·Π΄ΠΎΡ€ΠΎΠ²Π»Π΅Π½ΠΈΠ΅ Ρ€Π΅Π±Π΅Π½ΠΊΠ° наступило послС примСнСния ΠΌΠ΅Ρ‚ΠΈΠ»ΠΏΡ€Π΅Π΄Π½ΠΈΠ·ΠΎΠ»ΠΎΠ½Π° Π² Π΄ΠΎΠ·Π΅ 2,7 ΠΌΠ³/ΠΊΠ³ ΠΏΡ€ΠΎΠ΄ΠΎΠ»ΠΆΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎΡΡ‚ΡŒΡŽ 28 Π΄Π½Π΅ΠΉ, с постСпСнной ΠΎΡ‚ΠΌΠ΅Π½ΠΎΠΉ ΠΌΠ΅Π΄ΠΈΠΊΠ°ΠΌΠ΅Π½Ρ‚Π°.Π’Ρ‹Π²ΠΎΠ΄Ρ‹.Β Π’Π΅ΠΌΠ° являСтся Π°ΠΊΡ‚ΡƒΠ°Π»ΡŒΠ½ΠΎΠΉ Π² ΠΏΡ€Π°ΠΊΡ‚ΠΈΠΊΠ΅ Π²Ρ€Π°Ρ‡Π΅ΠΉ Ρ€Π°Π·Π»ΠΈΡ‡Π½Ρ‹Ρ… ΡΠΏΠ΅Ρ†ΠΈΠ°Π»ΡŒΠ½ΠΎΡΡ‚Π΅ΠΉ, ΠΏΠΎΡΠΊΠΎΠ»ΡŒΠΊΡƒ ΠΎΡ‚ ΠΏΡ€Π°Π²ΠΈΠ»ΡŒΠ½ΠΎΠΉ Π²Π΅Ρ€ΠΈΡ„ΠΈΠΊΠ°Ρ†ΠΈΠΈ клиничСского Π΄ΠΈΠ°Π³Π½ΠΎΠ·Π° зависит ΡΠ²ΠΎΠ΅Π²Ρ€Π΅ΠΌΠ΅Π½Π½ΠΎΡΡ‚ΡŒ, Π°Π΄Π΅ΠΊΠ²Π°Ρ‚Π½ΠΎΡΡ‚ΡŒ ΠΈ Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚ лСчСния Π±ΠΎΠ»Π΅Π·Π½ΠΈ.ИсслСдованиС Π²Ρ‹ΠΏΠΎΠ»Π½Π΅Π½ΠΎ Π² соотвСтствии с ΠΏΡ€ΠΈΠ½Ρ†ΠΈΠΏΠ°ΠΌΠΈ Π₯Сльсинкской Π”Π΅ΠΊΠ»Π°Ρ€Π°Ρ†ΠΈΠΈ. ΠŸΡ€ΠΎΡ‚ΠΎΠΊΠΎΠ» исслСдования ΠΎΠ΄ΠΎΠ±Ρ€Π΅Π½ Π›ΠΎΠΊΠ°Π»ΡŒΠ½Ρ‹ΠΌ этичСским ΠΊΠΎΠΌΠΈΡ‚Π΅Ρ‚ΠΎΠΌ всСх ΡƒΡ‡Π°ΡΡ‚Π²ΡƒΡŽΡ‰ΠΈΡ… ΡƒΡ‡Ρ€Π΅ΠΆΠ΄Π΅Π½ΠΈΠΉ. На ΠΏΡ€ΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠ΅ исслСдований ΠΏΠΎΠ»ΡƒΡ‡Π΅Π½ΠΎ ΠΈΠ½Ρ„ΠΎΡ€ΠΌΠΈΡ€ΠΎΠ²Π°Π½Π½ΠΎΠ΅ согласиС Ρ€ΠΎΠ΄ΠΈΡ‚Π΅Π»Π΅ΠΉ Ρ€Π΅Π±Π΅Π½ΠΊΠ°.Авторы Π·Π°ΡΠ²Π»ΡΡŽΡ‚ ΠΎΠ± отсутствии ΠΊΠΎΠ½Ρ„Π»ΠΈΠΊΡ‚Π° интСрСсов.ΠŸΠ°Ρ€Π²ΠΎΠ²iрус Π’19 (PVB19), колишня Π½Π°Π·Π²Π° Сритровірус B19, Ρ” Π΅Ρ‚Ρ–ΠΎΠ»ΠΎΠ³Ρ–Ρ‡Π½ΠΈΠΌ Π°Π³Π΅Π½Ρ‚ΠΎΠΌ Ρ‚.Π·. Β«ΠΏ'ятої Ρ…Π²ΠΎΡ€ΠΎΠ±ΠΈΒ», яка ΠΏΠ΅Ρ€Π΅Π²Π°ΠΆΠ½ΠΎ Π·ΡƒΡΡ‚Ρ€Ρ–Ρ‡Π°Ρ”Ρ‚ΡŒΡΡ Ρƒ дитячому ΠΉ ΠΏΡ–Π΄Π»Ρ–Ρ‚ΠΊΠΎΠ²ΠΎΠΌΡƒ Π²Ρ–Ρ†Ρ–. Π’Π°ΠΊΠΎΠΆ ΠΉΠΎΠ³ΠΎ ΠΏΠΎΠ²'ΡΠ·ΡƒΡŽΡ‚ΡŒ Ρ–Π· ΠΏΠΎΠ»Ρ–ΠΌΠΎΡ€Ρ„Π½ΠΎΡŽ ΠΊΠ»Ρ–Π½Ρ–Ρ‡Π½ΠΎΡŽ ΠΏΡ€Π΅Π·Π΅Π½Ρ‚Π°Ρ†Ρ–Ρ”ΡŽ, апластичними ΠΊΡ€ΠΈΠ·Π°ΠΌΠΈ, Π³Π΅ΠΌΠΎΠ»Ρ–Ρ‚ΠΈΡ‡Π½ΠΎΡŽ Π°Π½Π΅ΠΌΡ–Ρ”ΡŽ, Ρ‚Ρ€ΠΎΠΌΠ±ΠΎΡ†ΠΈΡ‚ΠΎΠΏΠ΅Π½Ρ–Ρ”ΡŽ Ρ‚ΠΎΡ‰ΠΎ, Π° Ρƒ ΠΏΠΎΡ€ΠΎΠ΄Ρ–Π»ΡŒ β€” Π·Ρ– ΡΠ°ΠΌΠΎΠ²Ρ–Π»ΡŒΠ½ΠΈΠΌΠΈ Π°Π±ΠΎΡ€Ρ‚Π°ΠΌΠΈ.ΠšΠ»Ρ–Π½Ρ–Ρ‡Π½ΠΈΠΉ Π²ΠΈΠΏΠ°Π΄ΠΎΠΊ. НавСдСно ΠΊΠ»Ρ–Π½Ρ–Ρ‡Π½Π΅ спостСрСТСння PVB19-Π²Ρ–Ρ€Π΅ΠΌΡ–Ρ—, яка Ρƒ Π΄Π²ΠΎΡ€Ρ–Ρ‡Π½ΠΎΠ³ΠΎ ΠΏΠ°Ρ†Ρ–Ρ”Π½Ρ‚Π° Π±ΡƒΠ»Π° ΠΏΡ€ΠΈΡ‡ΠΈΠ½ΠΎΡŽ систСмного ураТСння. ΠΠΊΡ†Π΅Π½Ρ‚ΡƒΡ”Ρ‚ΡŒΡΡ ΡƒΠ²Π°Π³Π° Π½Π° Ρ‚Ρ€ΠΈΠ²Π°Π»Ρ–ΠΉ Π΄ΠΈΡ„Π΅Ρ€Π΅Π½Ρ†Ρ–Π°Π»ΡŒΠ½Ρ–ΠΉ діагностиці Π΅ΠΊΠ·Π°Π½Ρ‚Π΅ΠΌΠΈ Π² ΠΏΠΎΡ”Π΄Π½Π°Π½Π½Ρ– Ρ–Π· Π³Π΅ΠΏΠ°Ρ‚ΠΎΡΠΏΠ»Π΅Π½ΠΎΠΌΠ΅Π³Π°Π»Ρ–Ρ”ΡŽ, полісСрозитом Ρ– Π»Π΅ΠΉΠΊΠΎΠΏΠ΅Π½Ρ–Ρ”ΡŽ Ρ–Π· Π½Π΅ΠΉΡ‚Ρ€ΠΎΠΏΠ΅Π½Ρ–Ρ”ΡŽ, Π°Π½Π΅ΠΌΡ–Ρ”ΡŽ Ρ‚Π° Ρ‚Ρ€ΠΎΠΌΠ±ΠΎΡ†ΠΈΡ‚ΠΎΠΏΠ΅Π½Ρ–Ρ”ΡŽ Ρ–Π½Ρ„Π΅ΠΊΡ†Ρ–ΠΉΠ½ΠΎΠ³ΠΎ Ρ‚Π° Π½Π΅Ρ–Π½Ρ„Π΅ΠΊΡ†Ρ–ΠΉΠ½ΠΎΠ³ΠΎ Π³Π΅Π½Π΅Π·Ρƒ, Π² Ρ‚.Ρ‡. Π²ΠΈΠΊΠ»ΡŽΡ‡Π°Π»ΠΈΡΡ нСопластичний процСс, ΠΊΠΎΠ»Π°Π³Π΅Π½ΠΎΠ·. Для Π²Π΅Ρ€ΠΈΡ„Ρ–ΠΊΠ°Ρ†Ρ–Ρ— Π΄Ρ–Π°Π³Π½ΠΎΠ·Ρƒ виконувалися числСнні ΠΌΡ–ΠΊΡ€ΠΎΠ±Ρ–ΠΎΠ»ΠΎΠ³Ρ–Ρ‡Π½Ρ– тСсти, аспіраційна Ρ‚Π° Ρ‚Ρ€Π΅ΠΏΠ°Π½Π°Ρ†Ρ–ΠΉΠ½Π° біопсія кісткового ΠΌΠΎΠ·ΠΊΡƒ (КМ), пункція ΠΏΠ»Π΅Π²Ρ€Π°Π»ΡŒΠ½ΠΎΡ— Ρ€Ρ–Π΄ΠΈΠ½ΠΈ, біопсія ΡˆΠΊΡ–Ρ€ΠΈ; застосовувалися ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΈ Π²Ρ–Π·ΡƒΠ°Π»Ρ–Π·Π°Ρ†Ρ–Ρ—: ΡƒΠ»ΡŒΡ‚Ρ€Π°Π·Π²ΡƒΠΊΠΎΠ²Π΅ дослідТСння, рСнтгСнографія ΠΎΡ€Π³Π°Π½Ρ–Π² Π³Ρ€ΡƒΠ΄Π½ΠΎΡ— ΠΊΠ»Ρ–Ρ‚ΠΊΠΈ, ΠΊΠΎΠΌΠΏ'ΡŽΡ‚Π΅Ρ€Π½Π° томографія. Π£ КМ ΠΏΡ€ΠΈ Ρ†ΠΈΡ‚ΠΎΠ»ΠΎΠ³Ρ–Ρ‡Π½ΠΎΠΌΡƒ ΠΉ гістологічному дослідТСнні виявлСно Π³Ρ–Π³Π°Π½Ρ‚ΡΡŒΠΊΡ– Π΅Ρ€ΠΈΡ‚Ρ€ΠΎΡ—Π΄Π½Ρ– ΠΊΠ»Ρ–Ρ‚ΠΈΠ½Π½Ρ– Π΅Π»Π΅ΠΌΠ΅Π½Ρ‚ΠΈ Ρƒ стадії пронормобласта Π· Π²ΠΈΡ€Π°Π·Π½ΠΈΠΌΠΈ Π²Π½ΡƒΡ‚Ρ€Ρ–ΡˆΠ½ΡŒΠΎΡΠ΄Π΅Ρ€Π½ΠΈΠΌΠΈ Π²ΠΊΠ»ΡŽΡ‡Π΅Π½Π½ΡΠΌΠΈ Π· відтиснСнням Ρ…Ρ€ΠΎΠΌΠ°Ρ‚ΠΈΠ½Ρƒ Π΄ΠΎ ΠΏΠ΅Ρ€ΠΈΡ„Π΅Ρ€Ρ–Ρ— ядра, Ρ‰ΠΎ ΠΏΡ€ΠΈΠ·Π²Π΅Π»ΠΎ Π΄ΠΎ ΠΏΡ–Π΄ΠΎΠ·Ρ€ΠΈ Ρ‰ΠΎΠ΄ΠΎ PVB19-Ρ–Π½Ρ„Π΅ΠΊΡ†Ρ–Ρ—, яку ΠΏΡ–Π΄Ρ‚Π²Π΅Ρ€Π΄ΠΆΠ΅Π½ΠΎ Π·Π° допомогою ΠΌΠ΅Ρ‚ΠΎΠ΄Ρƒ ΠΏΠΎΠ»Ρ–ΠΌΠ΅Ρ€Π°Π·Π½ΠΎΠ»Π°Π½Ρ†ΡŽΠ³ΠΎΠ²ΠΈΡ… Ρ€Π΅Π°ΠΊΡ†Ρ–ΠΉ. ΠžΠ΄ΡƒΠΆΠ°Π½Π½Ρ Π΄ΠΈΡ‚ΠΈΠ½ΠΈ відбулося після застосування ΠΌΠ΅Ρ‚ΠΈΠ»ΠΏΡ€Π΅Π΄Π½Ρ–Π·ΠΎΠ»ΠΎΠ½Ρƒ Ρƒ Π΄ΠΎΠ·Ρ– 2,7 ΠΌΠ³/ΠΊΠ³ ΡƒΠΏΡ€ΠΎΠ΄ΠΎΠ²ΠΆ 28 Π΄Π½Ρ–Π², Π· ΠΏΠΎΡΡ‚ΡƒΠΏΠΎΠ²ΠΎΡŽ Π²Ρ–Π΄ΠΌΡ–Π½ΠΎΡŽ ΠΌΠ΅Π΄ΠΈΠΊΠ°ΠΌΠ΅Π½Ρ‚Ρƒ.Висновки.Β Π’Π΅ΠΌΠ° Ρ” Π°ΠΊΡ‚ΡƒΠ°Π»ΡŒΠ½ΠΎΡŽ Π² ΠΏΡ€Π°ΠΊΡ‚ΠΈΡ†Ρ– Π»Ρ–ΠΊΠ°Ρ€Ρ–Π² Ρ€Ρ–Π·Π½ΠΈΡ… ΡΠΏΠ΅Ρ†Ρ–Π°Π»ΡŒΠ½ΠΎΡΡ‚Π΅ΠΉ, ΠΎΡΠΊΡ–Π»ΡŒΠΊΠΈ Π²Ρ–Π΄ ΠΏΡ€Π°Π²ΠΈΠ»ΡŒΠ½ΠΎΡ— Π²Π΅Ρ€ΠΈΡ„Ρ–ΠΊΠ°Ρ†Ρ–Ρ— ΠΊΠ»Ρ–Π½Ρ–Ρ‡Π½ΠΎΠ³ΠΎ Π΄Ρ–Π°Π³Π½ΠΎΠ·Ρƒ Π·Π°Π»Π΅ΠΆΠΈΡ‚ΡŒ ΡΠ²ΠΎΡ”Ρ‡Π°ΡΠ½Ρ–ΡΡ‚ΡŒ, Π°Π΄Π΅ΠΊΠ²Π°Ρ‚Π½Ρ–ΡΡ‚ΡŒ Ρ‚Π° Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚ лікування.ДослідТСння Π²ΠΈΠΊΠΎΠ½Π°Π½Ρ– Π²Ρ–Π΄ΠΏΠΎΠ²Ρ–Π΄Π½ΠΎ Π΄ΠΎ ΠΏΡ€ΠΈΠ½Ρ†ΠΈΠΏΡ–Π² Π“Π΅Π»ΡŒΡΡ–Π½ΡΡŒΠΊΠΎΡ— Π”Π΅ΠΊΠ»Π°Ρ€Π°Ρ†Ρ–Ρ—. ΠŸΡ€ΠΎΡ‚ΠΎΠΊΠΎΠ» дослідТСння ΡƒΡ…Π²Π°Π»Π΅Π½ΠΈΠΉ Π›ΠΎΠΊΠ°Π»ΡŒΠ½ΠΈΠΌ Π΅Ρ‚ΠΈΡ‡Π½ΠΈΠΌ ΠΊΠΎΠΌΡ–Ρ‚Π΅Ρ‚ΠΎΠΌ всіх Π·Π°Π·Π½Π°Ρ‡Π΅Π½ΠΈΡ… Ρƒ Ρ€ΠΎΠ±ΠΎΡ‚Ρ– установ. На провСдСння Π΄ΠΎΡΠ»Ρ–Π΄ΠΆΠ΅Π½ΡŒ Π±ΡƒΠ»ΠΎ ΠΎΡ‚Ρ€ΠΈΠΌΠ°Π½ΠΎ Ρ–Π½Ρ„ΠΎΡ€ΠΌΠΎΠ²Π°Π½Ρƒ Π·Π³ΠΎΠ΄Ρƒ Π±Π°Ρ‚ΡŒΠΊΡ–Π² Π΄ΠΈΡ‚ΠΈΠ½ΠΈ.Автори Π·Π°ΡΠ²Π»ΡΡŽΡ‚ΡŒ ΠΏΡ€ΠΎ Π²Ρ–Π΄ΡΡƒΡ‚Π½Ρ–ΡΡ‚ΡŒ ΠΊΠΎΠ½Ρ„Π»Ρ–ΠΊΡ‚Ρƒ інтСрСсів

    Observations: Oceanic climate change and sea level

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    The oceans are warming. Over the period 1961 to 2003, global ocean temperature has risen by 0.10Β°C from the surface to a depth of 700 m. Consistent with the Third Assessment Report (TAR), global ocean heat content (0– 3,000 m) has increased during the same period, equivalent to absorbing energy at a rate of 0.21 Β± 0.04 W m–2 globally averaged over the Earth’s surface. Two-thirds of this energy is absorbed between the surface and a depth of 700 m. Global ocean heat content observations show considerable interannual and inter-decadal variability superimposed on the longer-term trend. Relative to 1961 to 2003, the period 1993 to 2003 has high rates of warming but since 2003 there has been some cooling

    Mild Concussion, but Not Moderate Traumatic Brain Injury, Is Associated with Long-Term Depression-Like Phenotype in Mice

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    Mild traumatic brain injuries can lead to long-lasting cognitive and motor deficits, increasing the risk of future behavioral, neurological, and affective disorders. Our study focused on long-term behavioral deficits after repeated injury in which mice received either a single mild CHI (mCHI), a repeated mild CHI (rmCHI) consisting of one impact to each hemisphere separated by 3 days, or a moderate controlled cortical impact injury (CCI). Shams received only anesthesia. Behavioral tests were administered at 1, 3, 5, 7, and 90 days post-injury (dpi). CCI animals showed significant motor and sensory deficits in the early (1-7 dpi) and long-term (90 dpi) stages of testing. Interestingly, sensory and subtle motor deficits in rmCHI animals were found at 90 dpi. Most importantly, depression-like behaviors and social passiveness were observed in rmCHI animals at 90 dpi. These data suggest that mild concussive injuries lead to motor and sensory deficits and affective disorders that are not observed after moderate TBI
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