Immunomodulation of murine collagen-induced arthritis by N, N-dimethylglycine and a preparation of Perna canaliculus

<p>Abstract</p> <p>Background</p> <p>Rheumatoid arthritis (RA) and its accepted animal model, murine collagen-induced arthritis (CIA), are classic autoimmune inflammatory diseases which require proinflammatory cytokine production for pathogenesis. We and others have previously used N, N-dimethylglycine (DMG) and extracts from the New Zealand green-lipped mussel <it>Perna canaliculus </it>(Perna) as potent immunomodulators to modify ongoing immune and/or inflammatory responses.</p> <p>Methods</p> <p>In our initial studies, we treated lipopolysaccahride (LPS) stimulated THP-1 monocytes <it>in vitro </it>with increasing concentrations of Perna extract or DMG. Additionally, we treated rat peripheral blood neutrophils with increasing concentrations of Perna extract and measured superoxide burst. In subsequent <it>in vivo </it>experiments, CIA was induced by administration of type II collagen; rats were prophylactically treated with either Perna or DMG, and then followed for disease severity. Finally, to test whether Perna and/or DMG could block or inhibit an ongoing pathologic disease process, we induced CIA in mice and treated them therapeutically with either of the two immunomodulators.</p> <p>Results</p> <p>Following LPS stimulation of THP-1 monocytes, we observed dose-dependent reductions in TNF-α and IL-12p40 production in Perna treated cultures. DMG treatment, however, showed significant increases in both of these cytokines in the range of 0.001–1 μM. We also demonstrate that <it>in vitro </it>neutrophil superoxide burst activity is dose-dependently reduced in the presence of Perna. Significant reductions in disease incidence, onset, and severity of CIA in rats were noted following prophylactic treatment with either of the two immunomodulators. More importantly, amelioration of mouse CIA was observed following therapeutic administration of Perna. In contrast, DMG appeared to have little effect in mice and may act in a species-specific manner.</p> <p>Conclusion</p> <p>These data suggest that Perna, and perhaps DMG, may be useful supplements to the treatment of RA in humans.</p

18. Laboratoire de botanique (organographie et physiologie) au Muséum

Van Tieghem Ph., Poisson Jules, Guignard L., Morot L. 18. Laboratoire de botanique (organographie et physiologie) au Muséum. In: Rapport sur l'École pratique des hautes études, 1882-1883. 1882. pp. 145-148

18. Laboratoire de botanique (organographie et physiologie) au Muséum

Van Tieghem Ph., Poisson Jules, Guignard L., Morot L. 18. Laboratoire de botanique (organographie et physiologie) au Muséum. In: Rapport sur l'École pratique des hautes études, 1882-1883. 1882. pp. 145-148

CWDM broadcast and select home network based on multimode fibre and a passive star architecture

We present a high capacity home network based on a multimode passive star and WDM technology, implementing triple play over IP, P2P Gigabit Ethernet and TV broadcasting. Issues concerning the use of MMF are discussed

CWDM broadcast and select home network based on multimode fibre and a passive star architecture

\u3cp\u3eWe present a high capacity home network based on a multimode passive star and WDM technology, implementing triple play over IP, P2P Gigabit Ethernet and TV broadcasting. Issues concerning the use of MMF are discussed.\u3c/p\u3

Cost optimization of optical in-building networks

\u3cp\u3eWe compare the CapEx and OpEx of in-building networks for fibre and Cat-5E solutions. For residential homes, our analysis shows that total network costs during economic lifetime are lowest for a point-to-point duplex POF topology.\u3c/p\u3

Optical home network based on an N×N multimode fiber architecture and CWDM technology Citation for published version (APA): Optical Home Network based on an NxN Multimode Fiber Architecture and CWDM Technology

Abstract: With this optical home network solution associating an NxN multimode architecture and CWDM technology, various applications and network topologies are supported by a unique multiformat infrastructure. Issues related to the use of MMF are discussed

Photonic in-building networks : architectures and advanced techniques

In-building networks delivering broadband wired and wireless services can be realized cost-effectively with duplex plastic optical fibre, particularly when sharing ducts of electrical power cabling. Point-to-point architectures are well-suited for residential buildings, and bus or star-bus ones for larger buildings