Induced Stem Cells as a Novel Multiple Sclerosis Therapy.

Stem cell replacement is providing hope for many degenerative diseases that lack effective therapeutic methods including multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous system. Transplantation of neural stem cells or mesenchymal stem cells is a potential therapy for MS thanks to their capacity for cell repopulation as well as for their immunomodulatory and neurotrophic properties. Induced pluripotent stem cell (iPSC), an emerging cell source in regenerative medicine, is also being tested for the treatment of MS. Remarkable improvement in mobility and robust remyelination have been observed after transplantation of iPSC-derived neural cells into demyelinated models. Direct reprogramming of somatic cells into induced neural cells, such as induced neural stem cells (iNSCs) and induced oligodendrocyte progenitor cells (iOPCs), without passing through the pluripotency stage, is an alternative for transplantation that has been proved effective in the congenital hypomyelination model. iPSC technology is rapidly progressing as efforts are being made to increase the efficiency of iPSC therapy and reduce its potential side effects. In this review, we discuss the recent advances in application of stem cells, with particular focus on induced stem/progenitor cells (iPSCs, iNSC, iOPCs), which are promising in the treatment of MS

A comparison of electronic health records at two major Peking University Hospitals in China to United States meaningful use objectives

BACKGROUND: In accordance with the People’s Republic of China’s (China) National Health Reform Plan of 2009, two of the nation’s leading hospitals, located in Beijing, have implemented electronic medical record (EMR) systems from different vendors. To inform future EMR adoption and policy in China, as well as informatics research in the US, this study compared the United State’s Hospital Meaningful Use (MU) Objectives (phase 1) objectives to the EMR functionality of two early hospital EMR adopters in China. METHODS: At both hospitals, the researchers observed a physician using the EMR and noted MU functionality that was seen and functionality that was not seen yet was available in the EMR. The information technology department was asked about the availability of functionality neither observed nor known to the physician. RESULTS AND CONCLUSIONS: Approximately half the MU objectives were available in each EMR. Some differences between the EMRs in the study and MU objectives were attributed to operational differences between the health systems and the cultures in the two countries

Asymmetric impacts of technology innovation and environmental quality on tourism development in emerging economies

Tourism development contributes to higher economic output and is highly integrated with environmental quality and associated technologies. Although many studies explore the impact of tourism on carbon emissions; however, little is known regarding the effects of environmental pollution and technology innovation on tourism growth. Therefore, this study examines the impact of technology innovation and environmental pollution on inbound tourism in emerging economies. In doing so, we employ a recently developed panel quantiles regression and found that technology innovation and economic growth stimulate inbound tourism while increasing emissions limit tourist arrivals. These effects are not equally observed across all quantiles. Particularly, the impact of technology innovation is highest at higher quantiles, while the impact of the emissions is highest at lower quantiles. These results suggest that inbound tourism is asymmetrically affected by technology innovation and environmental quality of host destinations. Hence, emerging economies should encourage sustainable tourism by integrating green technologies and minimizing ecological hazards