Catalogación básica

En esta presentación se dan unas nociones básicas sobre catalogación bibliográfica ; las Reglas de Catalogación ; el Formato Ibermarc y catalogación en el Catálogo Informatizado de la Red de Bibliotecas del CSIC.Peer reviewe

GluK2-mediated excitability within the superficial layers of the entorhinal cortex

11 pages, 6 pages.-- PMID: 19440371 [PubMed].-- PMCID: PMC2679203.-- Supporting information available: Figure S1, doi:10.1371/journal.pone.0005576.s001 (0.63 MB TIF).Recent analysis of genetically modified mice deficient in different kainate receptor (KAR) subunits have strongly pointed to a role of the GluK2 subunit, mediating the vulnerability of the brain towards seizures. Research concerning this issue has focused mainly on the hippocampus. However, several studies point to a potential role of other parts of the hippocampal formation, in particular the entorhinal cortex, in the development of epileptic seizures. There is extensive cell death after such seizures in layer III of the medial entorhinal cortex (LIII mEC), making this region of special interest for investigation into related pathological conditions. We therefore characterized KAR mediated currents in LIII mEC pyramidal neurons by several different approaches. Using patch-clamp technique, in combination with glutamate uncaging in horizontal brain slices, we show that LIII mEC neurons exhibit KAR currents. Use of genetically modified mice reveal that these currents are mediated by GluK2 containing KARs. The IV curve indicates the predominant presence of a Ca2+ impermeable and edited form of the KAR. Finally, we show that GluK2 containing kainate receptors are essential for kainate-induced gamma oscillations within the entorhinal cortex.This study has been funded by the SFB 665 grant and P.B. is a member of and funded by the GRK 1123.Peer reviewe

Разработка технологии изготовления детали «Крышка»

Цели и задачи исследования: разработка технологического процесса изготовления детали крышка и конструирование приспособления. Актуальность работы определяется необходимостью разработки технологического процесса изготовления конкретной детали "Крышка", который обеспечивает требуемую точность. Объектом исследования является деталь "Крышка".Goals and objectives of the research: development of a technological process for manufacturing a part of a cover and design of a device. The relevance of the work is determined by the need to develop a technological process for the manufacture of a specific "Cover" part, which provides the required accuracy. The object of research is the "Cover" detail