Inclusion and Disability as Curricular Practice

As policies regarding students with disabilities in education have changed to support inclusive approaches, the field of art education must consider the translation of these concepts to Prek-12 art and design curriculum. This study examines inclusive curriculum content regarding the inclusion and representation of disability in Prek-12 visual art and design classrooms in Illinois. It utilized a descriptive survey design that involved art and design education teachers throughout the state. These data provide information on the general state of art and design education while also considering the connections between theory and practice. Data from this study indicate that although art teachers include representations of disability as part of their curriculum, further inclusion of disability arts could be made. This article contributes to research examining the intersection between disability studies, inclusion, and special education in Prek-12 schools

What Drives Car Attitudes: An Analysis of How Demographics and Environmental Views Relate to Car Attitudes

Successfully marketing new, clean, car technologies to consumers requires an advertising strategy that fits consumers’ priorities and attitudes towards cars. We created a survey to study how attitudes towards cars are associated with demographics and environmental views. Our study examined car preferences and environmental concerns of a sample of Gettysburg College students in comparison to a national sample obtained from Amazon’s Mechanical Turk. Overall, we concluded that environmental beliefs are a significantly better prediction of car behaviors than demographics. We found that on average people would pay more for a car with a higher fuel economy, but not enough to cover the higher price of newer, cleaner technologies, such as hybrid cars. Gettysburg College students’ environmental concern scores were significantly higher on average than that of the general American population. Survey respondents from both samples supported devoting more research and resources to hybrid, electric, and biofuel technologies. However, in regards to their personal purchases they ranked safety and other qualities of the car as higher priorities than greenhouse gas emissions or fuel economy. According to our results, marketing electric cars as safe and reliable is a better strategy than marketing their high fuel economy

Pole Term and Gauge Invariance in Deep Inelastic Scattering

In this paper we reconcile two contradictory statements about deep inelastic scattering (DIS) in manifestly covariant theories: (i) the scattering must be gauge invariant, even in the deep inelastic limit, and (ii) the pole term (which is not gauge invariant in a covariant theory) dominates the scattering amplitude in the deep inelastic limit. An ``intermediate'' answer is found to be true. We show that, at all energies, the gauge dependent part of the pole term cancels the gauge dependent part of the rescattering term, so that both the pole and rescattering terms can be separately redefined in a gauge invariant fashion. The resulting, redefined pole term is then shown to dominate the scattering in the deep inelastic limit. Details are worked out for a simple example in 1+1 dimensions.Comment: 10 figure

Tetrahydroaminoacridine (THA) reduces voltage-dependent calcium currents in rat sensory neurons

Tetrahydroaminoacridine (THA) is a centrally active anticholinesterase that also interacts with neuronal K+ and Na+ channels and cardiac Ca2+ channels. The effects of THA on neuronal voltage-dependent Ca2+ channels are not known. We tested the effects of THA (25 nM-250 [mu]M) on the Ca2+ current components of acutely dissociated rat nodose ganglion and dorsal root ganglion (DRG) neurons using the whole cell patch clamp recording technique. THA reduced the low-threshold (T) and high-threshold (N/L) Ca2+ current components in a concentration-dependent manner (IC50 [congruent with] 125 [mu]M for T; [congruent with] 80 [mu]M for (N/L). Minimal current reduction was seen below ~ 10 [mu]M. Our results show that THA reduces voltage-dependent Ca2+ currents in rodent sensory neurons suggesting another means by which THA may affect Ca2+-dependent physiologic processes.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/29032/1/0000064.pd

Heated nuclear matter, condensation phenomena and the hadronic equation of state

The thermodynamic properties of heated nuclear matter are explored using an exactly solvable canonical ensemble model. This model reduces to the results of an ideal Fermi gas at low temperatures. At higher temperatures, the fragmentation of the nuclear matter into clusters of nucleons leads to features that resemble a Bose gas. Some parallels of this model with the phenomena of Bose condensation and with percolation phenomena are discussed. A simple expression for the hadronic equation of state is obtained from the model.Comment: 12 pages, revtex, 1 ps file appended (figure 1

TGF-beta 1 induces human alveolar epithelial to mesenchymal cell transition (EMT)

Background: Fibroblastic foci are characteristic features in lung parenchyma of patients with idiopathic pulmonary fibrosis (IPF). They comprise aggregates of mesenchymal cells which underlie sites of unresolved epithelial injury and are associated with progression of fibrosis. However, the cellular origins of these mesenchymal phenotypes remain unclear. We examined whether the potent fibrogenic cytokine TGF-β1 could induce epithelial mesenchymal transition (EMT) in the human alveolar epithelial cell line, A549, and investigated the signaling pathway of TGF-β1-mediated EMT. Methods: A549 cells were examined for evidence of EMT after treatment with TGF-β1. EMT was assessed by: morphology under phase-contrast microscopy; Western analysis of cell lysates for expression of mesenchymal phenotypic markers including fibronectin EDA (Fn-EDA), and expression of epithelial phenotypic markers including E-cadherin (E-cad). Markers of fibrogenesis, including collagens and connective tissue growth factor (CTGF) were also evaluated by measuring mRNA level using RT-PCR, and protein by immunofluorescence or Western blotting. Signaling pathways for EMT were characterized by Western analysis of cell lysates using monoclonal antibodies to detect phosphorylated Erk1/2 and Smad2 after TGF-β1 treatment in the presence or absence of MEK inhibitors. The role of Smad2 in TGF-β1-mediated EMT was investigated using siRNA. Results: The data showed that TGF-β1, but not TNF-α or IL-1β, induced A549 cells with an alveolar epithelial type II cell phenotype to undergo EMT in a time-and concentration-dependent manner. The process of EMT was accompanied by morphological alteration and expression of the fibroblast phenotypic markers Fn-EDA and vimentin, concomitant with a downregulation of the epithelial phenotype marker E-cad. Furthermore, cells that had undergone EMT showed enhanced expression of markers of fibrogenesis including collagens type I and III and CTGF. MMP-2 expression was also evidenced. TGF-β1-induced EMT occurred through phosphorylation of Smad2 and was inhibited by Smad2 gene silencing; MEK inhibitors failed to attenuate either EMT-associated Smad2 phosphorylation or the observed phenotypic changes. Conclusion: Our study shows that TGF-β1 induces A549 alveolar epithelial cells to undergo EMT via Smad2 activation. Our data support the concept of EMT in lung epithelial cells, and suggest the need for further studies to investigate the phenomenon

Relativistic Structure of the Deuteron: 1.Electro-disintegration and y-scaling

Realistic solutions of the spinor-spinor Bethe-Salpeter equation for the deuteron with realistic interaction kernel including the exchange of pi, sigma, omega, rho, eta and delta mesons, are used to systematically investigate relativistic effects in inclusive quasi-elastic electron-deuteron scattering within the relativistic impulse approximation. Relativistic y-scaling is considered by generalising the non relativistic scaling function to the relativistic case, and it is shown that y-scaling does occur in the usual relativistic scaling variable resulting from the energy conservation in the instant form of dynamics. The present approach of y-scaling is fully covariant, with the deuteron being described by eight components, viz. the 3S_1^{++}, 3S_1^{--}, 3D_1^{++}, 3D_1^{--}, 3P_1^{+-}, 3P_1^{-+}, 1P_1^{+-}, 1P_1^{-+} waves. It is demonstrated that if the negative relative energy states 1P_1, 3P_1 are disregarded, the concept of covariant momentum distributions N(p_0,p), with p_0=M_D/2-\sqrt{p^2+m^2}, can be introduced, and that calculations of lectro-disintegration cross section in terms of these distributions agree within few percents with the exact calculations which include the 1P_1, 3P_1 states, provided the nucleon three momentum |p|\<= 1 GeV/c; in this momentum range, the asymptotic relativistic scaling function is shown to coincide with the longitudinal covariant momentum distribution.Comment: 32 LaTeX pages, 18 eps-figures. Final version to appear in Phys. Rev.

Inclusion of virtual nuclear excitations in the formulation of the (e,e'N)

A wave-function framework for the theory of the (e,e'N) reaction is presented in order to justify the use of coupled channel equations in the usual Feynman matrix element. The overall wave function containing the electron and nucleon coordinates is expanded in a basis set of eigenstates of the nuclear Hamiltonian, which contain both bound states as well as continuum states.. The latter have an ingoing nucleon with a variable momentum Q incident on the daughter nucleus as a target, with as many outgoing channels as desirable. The Dirac Eqs. for the electron part of the wave function acquire inhomogeneous terms, and require the use of distorted electron Green's functions for their solutions. The condition that the asymptotic wave function contain only the appropriate momentum Q_k for the outgoing nucleon, which corresponds to the electron momentum k through energy conservation, is achieved through the use of the steepest descent saddle point method, commonly used in three-body calculations.Comment: 30 page

Breakup of 17^{17}F on 208^{208}Pb near the Coulomb barrier

Angular distributions of oxygen produced in the breakup of $^{17}$F incident on a $^{208}$Pb target have been measured around the grazing angle at beam energies of 98 and 120 MeV. The data are dominated by the proton stripping mechanism and are well reproduced by dynamical calculations. The measured breakup cross section is approximately a factor of 3 less than that of fusion at 98 MeV. The influence of breakup on fusion is discussed.Comment: 7 pages, 8 figure

Reduction in podocyte density as a pathologic feature in early diabetic nephropathy in rodents: Prevention by lipoic acid treatment

BACKGROUND: A reduction in the number of podocytes and podocyte density has been documented in the kidneys of patients with diabetes mellitus. Additional studies have shown that podocyte injury and loss occurs in both diabetic animals and humans. However, most studies in animals have examined relatively long-term changes in podocyte number and density and have not examined effects early after initiation of diabetes. We hypothesized that streptozotocin diabetes in rats and mice would result in an early reduction in podocyte density and that this reduction would be prevented by antioxidants. METHODS: The number of podocytes per glomerular section and the podocyte density in glomeruli from rats and mice with streptozotocin (STZ)-diabetes mellitus was determined at several time points based on detection of the glomerular podocyte specific antigens, WT-1 and GLEPP1. The effect of insulin administration or treatment with the antioxidant, α-lipoic acid, on podocyte number was assessed. RESULTS: Experimental diabetes resulted in a rapid decline in apparent podocyte number and podocyte density. A significant reduction in podocytes/glomerular cross-section was found in STZ diabetes in rats at 2 weeks (14%), 6 weeks (18%) and 8 weeks (34%) following STZ injection. Similar declines in apparent podocyte number were found in STZ diabetes in C57BL/6 mice at 2 weeks, but not at 3 days after injection. Treatment with α-lipoic acid substantially prevented podocyte loss in diabetic rats but treatment with insulin had only a modest effect. CONCLUSION: STZ diabetes results in reduction in apparent podocyte number and in podocyte density within 2 weeks after onset of hyperglycemia. Prevention of these effects with antioxidant therapy suggests that this early reduction in podocyte density is due in part to increased levels of reactive oxygen species as well as hyperglycemia