John's ellipsoid and the integral ratio of a log-concave function

We extend the notion of John’s ellipsoid to the setting of integrable log-concave functions. This will allow us to define the integral ratio of a log-concave function, which will extend the notion of volume ratio, and we will find the log-concave function maximizing the integral ratio. A reverse functional affine isoperimetric inequality will be given, written in terms of this integral ratio. This can be viewed as a stability version of the functional affine isoperimetric inequality.Ministerio de Economía y CompetitividadFondo Europeo de Desarrollo RegionalConsejería de Industria, Turismo, Empresa e Innovación (Comunidad Autónoma de la Región de Murcia)Coordenação de aperfeiçoamento de pessoal de nivel superiorInstituto Nacional de Matemática Pura e Aplicad

Improving the Arc-Eager Model with Reverse Parsing

A known way to improve the accuracy of dependency parsers is to combine several different parsing algorithms, in such a way that the weaknesses of each of the models can be compensated by the strengths of others. For example, voting-based combination schemes are based on variants of the idea of analyzing each sentence with various parsers, and constructing a combined output where the head of each node is determined by "majority vote" among the different parsers. Typically, such approaches combine very different parsing models to take advantage of the variability in the parsing errors they make. In this paper, we show that consistent improvements in accuracy can be obtained in a much simpler way by combining a single parser with itself. In particular, we start with a greedy implementation of the Nivre pseudo-projective arc-eager algorithm, a well-known left-to-right transition-based parser, and we combine it with a "mirrored" version of the algorithm that analyzes sentences from right to left. To determine which of the two obtained outputs we trust for the head of each node, we use simple criteria based on the length and position of dependency arcs. Experiments on several datasets from the CoNLL-X shared task and the WSJ section of the English Penn Treebank show that the novel combination system obtains better performance than the baseline arc-eager parser in all cases. To test the generality of the approach, we also perform experiments with a different transition system (arc-standard) and a different search strategy (beam search), obtaining similar improvements in all these settings

Electrothermoplasmonic flow in gold nanoparticles suspensions: nonlinear dependence of flow velocity on aggregate concentration

Efficient mixing and pumping of liquids at the microscale is a technology that is still to be optimized. The combination of an AC electric field with a small temperature gradient leads to a strong electrothermal flow that can be used for multiple purposes. Combining simulations and experiments, an analysis of the performance of electrothermal flow is provided when the temperature gradient is generated by illuminating plasmonic nanoparticles in suspension with a near-resonance laser. Fluid flow is measured by tracking the velocity of fluorescent tracer microparticles in suspension as a function of the electric field, laser power, and concentration of plasmonic particles. Among other results, a non-linear relationship is found between the velocity of the fluid and particle concentration, which is justified in terms of multiple scattering-absorption events, involving aggregates of nanoparticles, that lead to enhanced absorption when the concentration is raised. Simulations provide a description of the phenomenon that is compatible with experiments and constitute a way to understand and estimate the absorption and scattering cross-sections of both dispersed particles and/or aggregates. A comparison of experiments and simulations suggests that there is some aggregation of the gold nanoparticles by forming clusters of about 2–7 particles, but no information about their structure can be obtained without further theoretical and experimental developments. This nonlinear behavior could be useful to get very high ETP velocities by inducing some controlled aggregation of the particles.This research has been supported by Consejería de Universidad, Investigación e Innovación de la Junta de Andalucía and FEDER, “Una manera de hacer Europa”/Projects P18-FR-3583 and FQM-410-UGR18, Ministerio de Ciencia, Innovación y Universidades through Project EQC2018-004693-P, and Grant PID2021-127427NB-I00/ MCIN/AEI/10.13039/501100011033/FEDER,UE. Funding for open access charge: Universidad de Málaga/CBUA

Arbitrage pricing theory : evidencia empírica para el mercado accionario colombiano, 2005 - 2012

Ross (1976) introduce un modelo alternativo al CAPM para explicar el rendimiento de los activos financieros. El modelo APT de Ross propone una estructura multifactorial, en la cual el rendimiento de un activo financiero es función de una tasa libre de riesgo y de variables macroeconómicas. En este trabajo se utiliza el método de componentes principales para resumir la información de 23 variables macroeconómicas y financieras y luego se utilizan estos resultados para modelar el rendimiento en exceso sobre los títulos de deuda pública, TES, del Índice General de la Bolsa de Valores de Colombia. Las componentes encontradas se analizan a la luz de la teoría económica y financiera y se encuentra evidencia para afirmar que la percepción del riesgo es el factor con importancia relativa más alta para la explicación del exceso de rendimiento del IGBC.44 p.Ross (1976) introduced an alternative to the CAPM model to explain the returns of financial assets. Ross’ Arbitrage Pricing Theory (APT) proposes a multi-factor structure in which the return of a given financial asset is a function of a free-risk rate and a series of macroeconomic variables. In this paper the principal component analysis is used to summarise the information contained in 23 macroeconomic and financial variables and then the components retained are used to model the excess of return over the local currency government bonds, TES, of the Colombian Stock Exchange General Index (IGBC). The retained principal components were analysed in the light of the economic and financial theory and evidence was found to assert that the risk perception has the highest relative importance to explain the IGBC excess of return

Re-warm-up practices in elite and sub-elite Spanish men's and women's basketball team:practitioners' perspectives

[EN] Objective: Research suggests that an active re-warm-up (RW-U) during half-time improves performance capacity in team sports, despite limited evidence in basketball. This study aimed to identify the practice of RW-U activities during the half-time period in elite and sub-elite Spanish men's and women's basketball teams. Methods: We asked strength and conditioning coaches from all teams competing at ACB, LF, LF2, LEB Oro, LEB Plata and EBA leagues during the 2020/21 season to fill in a web survey. Results: All respondents reported familiarization with the RW-U concept, although 45% only reproduced traditional strategies. Half of the coaches indicated that they always performed some activity, while the other half pointed out lack of time (45.7%) and player demands (62.9%) as the main constraints impeding its regular use. Conclusion: Spanish basketball teams continue to reproduce traditional practices of active re-warm-up during half-time, regardless of their competitive level

Hairy cell leukemia, an uncommon B-cell lymphoid neoplasia

Hairy cell leukemia (HCL) is an uncommon B-cell lymphoid neoplasia, representing 2---3% of all leukemias. It is more common in men, with a median age at diagnosis of 52 years. The hair-like projections on its surface are its principal characteristic. Although its etiology has not been established, the recent gene sequencing of HCL identified the presence of the BRAF V600E mutation, absent in other malignant neoplasias of the lymph cells. The clinical course of the disease is usually indolent. The majority of patients initially present weakness and fatigue, pancytopenia and splenomegaly. HCL must be distinguished from other indolent lymphoid neoplasias such as prolymphocytic leukemia, splenic marginal zone lymphoma, the variant of HCL (HCLv), and mantle cell lymphoma. Peripheral blood flow cytometer is essential for the detection of CD11c, CD19, CD20, CD22, CD25, and CD10, as well as a bone marrow aspirate to detect immunophenotypes. In addition, a bone biopsy is useful to perform an immunohistochemistry analysis for TRAP, DBA-44 and A1 annexin. Purine analogues remain the first line of treatment. However, interferon and rituximab are a valid option, if the ideal treatment is unavailable. New discoveries in the pathophysiology of HCL have brought the creation of pharmaceuticals with distinct therapeutic targets. These pharmaceuticals are currently undergoing testing

Redox-dependent and redox-independent functions of Caenorhabditis elegans thioredoxin 1

Thioredoxins (TRX) are traditionally considered as enzymes catalyzing redox reactions. However, redox-independent functions of thioredoxins have been described in different organisms, although the underlying molecular mechanisms are yet unknown. We report here the characterization of the first generated endogenous redox-inactive thioredoxin in an animal model, the TRX-1 in the nematode Caenorhabditis elegans. We find that TRX-1 dually regulates the formation of an endurance larval stage (dauer) by interacting with the insulin pathway in a redox-independent manner and the cGMP pathway in a redox-dependent manner. Moreover, the requirement of TRX-1 for the extended longevity of worms with compromised insulin signalling or under calorie restriction relies on TRX-1 redox activity. In contrast, the nuclear translocation of the SKN-1 transcription factor and increased LIPS-6 protein levels in the intestine upon trx-1 deficiency are strictly redox-independent. Finally, we identify a novel function of C. elegans TRX-1 in male food-leaving behaviour that is redox-dependent. Taken together, our results position C. elegans as an ideal model to gain mechanistic insight into the redox-independent functions of metazoan thioredoxins, overcoming the limitations imposed by the embryonic lethal phenotypes of thioredoxin mutants in higher organisms.NIH Office of Research Infrastructure P40 OD010440Spanish Ministry of Economy and Competitiveness BFU2015- 64408-PFondo Social Europeo BFU2015- 64408-PNational Institute of Allergy and Infectious Diseases of the National Institutes of Health R01AI07640

Tiroiditis por trauma en cuello luego de intento de suicidio. Reporte de caso y revisión de la literatura

La tiroiditis es un fenómeno inflamatorio de la tiroides, de causas diversas, incluyendo raramente traumas de la región anterior del cuello. Se presenta el caso de un paciente con depresión mayor de curso crónico, con síntomas sicóticos y farmacodependencia, quien intenta suicidarse mediante ahorcamiento. Ingresa con un Glasgow de 3/15, por lo cual requiere intubación orotraqueal inmediata, posterior traslado a unidad de cuidados intensivos y ventilación mecánica durante diez días. Durante este periodo desarrolla taquicardia persistente, diaforesis y alteraciones del sensorio, se encontró TSH en 0,00 (0,4- 4 mUI/ml); una T3 total en 2,42, (0,8-2,0 ng/ml) y T4 libre >6 (0,93-1,70 ng/dL), la gammagrafía de tiroides con tecnecio 99 mostró bloqueo de la captación. Se sospechó tormenta tiroidea y recibió propranolol 80 mg vía oral cada 8 horas en forma continua e hidrocortisona 50 mg intravenosa cada 8 horas durante 5 días. Los controles, dos semanas después, muestran TSH en 0,00 (0,4-4 uUI/ml) y una T4 libre de 1,78 (0,93-1,70 ng/dl) y cuatro días después normalización de la T4 libre (1,45 ng/dl), acompañado de mejoría clínica de los síntomas adrenérgicos. Se presenta el caso de un paciente con tiroiditis postrauma, entidad que debe ser sospechada en pacientes con trauma en el cuello que presenten síntomas de tirotoxicosis. Abstract Thyroiditis is an inflammatory disorder of the thyroid, which stems from a variety of causes including in some rare cases trauma to the neck. We present the case of a male patient with chronic depression associated with psychotic symptoms and drug abuse that tried to commit suicide through hanging. The patient had a Glasgow Coma Scale 3/15 requiring orotracheal intubation, a stay in the intensive care unit and mechanical ventilation for 10 days. While in the ICU the patient developed persistent tachycardia, diaphoresis and changes in mental status. A suppressed TSH was found with a level of 0,00 (0,4-4 uUI/ml) and high thyroid hormone level (total T 2,42, (normal value 0,8-2,0 ng/ml) and free T >6 (normal value 0,93-1,70 ng/dL). A technetium-99 thyroid scintygraphy showed blocked uptake. With those findings, a thyroid storm was suspected and management was begun with propranolol 80 mg per mouth every 8 hours and IV hydrocortisone 50 mg every 8 hours for 5 days. Two weeks later, the TSH was 0,00 (0,4-4 uUI/ ml) and the free T4 was 1,78 (normal value 0,93-1,70 ng/dl). Four days later, the free T4 concentration was normal (1,45 ng/dl) with a clinical improvement of the adrenergic symptoms. Inconclusion, thyroiditis should be suspected in patients with neck trauma with compatible clinical manifestations