Chandra observations of the massive star-forming region S106: X-ray emission from the embedded massive protostellar object IRS 4

We present Chandra observations of the massive star-forming region S106, a prominent HII region in Cygnus, associated with an extended molecular cloud and a young cluster. The nebula is excited by a single young massive star located at the center of the molecular cloud and the embedded cluster. The prominence of the cluster in the Chandra observation presented here confirms its youth and allows some of its members to be studied in more detail. We detect X-ray emission from the young massive central source S106 IRS 4, the deeply embedded central object which drives the bipolar nebula with a mass loss rate approximately 1-2 orders of magnitude higher than main sequence stars of comparable luminosity. Still, on the basis of its wind momentum flux the X-ray luminosity of S106 IRS 4 is comparable to the values observed in more evolved (main sequence and giant) massive stars, suggesting that the same process which is responsible for the observed X-ray emission from older massive stars is already at work at these early stages

The angular power spectrum of radio emission at 2.3 GHz

We have analysed the Rhodes/HartRAO survey at 2326 MHz and derived the global angular power spectrum of Galactic continuum emission. In order to measure the angular power spectrum of the diffuse component, point sources were removed from the map by median filtering. A least-square fit to the angular power spectrum of the entire survey with a power law spectrum C_l proportional to l^{-alpha}, gives alpha = 2.43 +/- 0.01 for l = 2-100. The angular power spectrum of radio emission appears to steepen at high Galactic latitudes and for observed regions with |b| > 20 deg, the fitted spectral index is alpha = 2.92 +/- 0.07. We have extrapolated this result to 30 GHz (the lowest frequency channel of Planck) and estimate that no significant contribution to the sky temperature fluctuation is likely to come from synchrotron at degree-angular scalesComment: 10 pages, 10 figures, accepted for publication by Astronomy & Astrophysic

Analysis of CMB foregrounds using a database for Planck

Within the scope of the Planck IDIS (Integrated Data Information System) project we have started to develop the data model for time-ordered data and full-sky maps. The data model is part of the Data Management Component (DMC), a software system designed according to a three-tier architecture which allows complete separation between data storage and processing. The DMC is already being used for simulation activities and the modeling of some foreground components. We have ingested several Galactic surveys into the database and used the science data-access interface to process the data. The data structure for full-sky maps utilises the HEALPix tessellation of the sphere. We have been able to obtain consistent measures of the angular power spectrum of the Galactic radio continuum emission between 408 MHz and 2417 MHz.Comment: 7 pages, 6 figures. To appear in the Proceedings of the MPA/ESO/MPE Joint Astronomy Conference "Mining The Sky

The Near-Infrared Spectrograph (NIRSpec) on the James Webb Space Telescope V. Optimal algorithms for planning multi-object spectroscopic observations

We present an overview of the capabilities and key algorithms employed in the so-called eMPT software suite developed for planning scientifically optimized, multi-object spectroscopic (MOS) observations with the Micro-Shutter Array (MSA) of the Near-Infrared Spectrograph (NIRSpec) instrument on board the James Webb Space Telescope (JWST), the first multi-object spectrograph to operate in space. NIRSpec MOS mode is enabled by a programmable MSA, a regular grid of ~250,000 individual apertures that projects to a static, semi-regular pattern of available slits on the sky and makes the planning and optimization of an MSA observation a rather complex task. As such, the eMPT package is offered to the NIRSpec user community as a supplement to the MSA Planning Tool (MPT) included in the STScI Astronomer's Proposal Tool (APT) to assist in the planning of NIRSpec MOS proposals requiring advanced functionality to meet ambitious science goals. The eMPT produces output that can readily be imported and incorporated into the user's observing program within the APT to generate a customized MPT MOS observation. Furthermore, its novel algorithms and modular approach make it highly flexible and customizable, providing users the option to finely control the workflow and even insert their own software modules to tune their MSA slit masks to the particular scientific objectives at hand

Complement system network in cell physiology and in human diseases

The complement system is a multi-functional system representing the first line host defense against pathogens in innate immune response, through three different pathways. Impairment of its function, consisting in deficiency or excessive deregulated activation, may lead to severe systemic infections or autoimmune disorders. These diseases may be inherited or acquired. Despite many diagnostic tools are currently available, ranging from traditional, such as hemolytic or ELISA based assays, to innovative ones, like next generation sequencing techniques, these diseases are often not recognized. As for therapeutic aspects, strategies based on the use of targeted drugs are now widespread. The aim of this review is to present an updated overview of complement system pathophysiology, clinical implications of its dysfunction and to summarize diagnostic and therapeutic approaches

Hardware prototyping and validation of a W-ΔDOR digital signal processor

Microwave tracking, usually performed by on ground processing of the signals coming from a spacecraft, represents a crucial aspect in every deep-space mission. Various noise sources, including receiver noise, affect these signals, limiting the accuracy of the radiometric measurements obtained from the radio link. There are several methods used for spacecraft tracking, including the Delta-Differential One-Way Ranging (ΔDOR) technique. In the past years, European Space Agency (ESA) missions relied on a narrowband ΔDOR system for navigation in the cruise phase. To limit the adverse effect of nonlinearities in the receiving chain, an innovative wideband approach to ΔDOR measurements has recently been proposed. This work presents the hardware implementation of a new version of the ESA X/Ka Deep Space Transponder based on the new tracking technique named Wideband ΔDOR (W-ΔDOR). The architecture of the new transponder guarantees backward compatibility with narrowband ΔDOR

Urban geomorphology of Genoa old city (Italy)

A multi-year geomorphological surveys of the city of Genoa allowed the creation of an original geomorphological map of the urban environment. The city of Genoa is internationally known for the importance of its port and for the presence of a historic city center recognized as an UNESCO World Heritage since 2006. The research methodology was based on the structuring and analysis of a multi-source geodatabase consisting of information acquired from scientific literature and technical reports, historical and recent photographs and maps, geological and environmental data related to land planning plans, original data from field surveys. Work phases of data elaboration included: 1) a multi-temporal cartographic comparison from the eighteenth-century to year 2016; 2) an analysis of aerial photographs in the period 1936-2016; 3) the interpretation of boreholes data; 4) both surface and underground geomorphological observations within the city centre, by means of field surveys and speleological techniques. The recognition of the former geomorphological setting on which the historical nucleus of Genoa has developed, and the interpretation of its paleogeographic, geological and tectonic conditions, are not an easy task: since the High Middle Ages of the Maritime Republic of Genoa, the superposition of multiple phases of urban sprawl has obliterated original geomorphic conditions. However, interpretation of the rich geodatabase allowed to classify landforms, processes and surficial deposits with respect to their original environment and morphogenesis, i.e due to: running waters, gravity, karst, action of the sea; but, above all, due to human activities. In fact, the entire study area has undergone continuous modifications by man through the all considered time interval, as shown by artificial land fillings at the seaside, alteration of the river network, excavations and fills on the slopes, with the highlighting of significant anthropogenic urban landforms. The geomorphological map support both a morpho-evolutionary and a functional approach to the geomorphological landscape the of Genoa old city: therefore, it can be a useful tool for land planning, also aimed at reducing the geo-hydrological risk that characterizes the urban area

Altered signaling through IL-12 receptor in children with very high serum IgE levels

An alteration of Th1/Th2 homeostasis may lead to diseases in humans. In this study, we investigated whether an impaired IL-12R signaling occurred in children with elevated serum IgE levels divided on the basis of the IgE levels (group A: >2000 kU/l; group B: <2000 kU/l). We evaluated the integrity of the IL-12R signaling through the analysis of phosphorylation/activation of STAT4, and mRNA expression and membrane assembly of the receptor chains. At a functional level, a proliferative defect of lymphocytes from group A patients was observed. In these patients, an abnormal IL-12R signaling was documented, and this finding was associated with abnormal expression of the IL-12Rb2 chain. Our data indicate that in patients with very high IgE levels the generation of Th1 response is impaired, and that this abnormality associates with abnormal IL-12R signaling