Determining of most Effective Factors on drought Useing of Panel Data Analyse (Khorasan Razavi Province)

Drought is a natural creeping event that starts due to lower moisture compared to normal condition. This phenomenon impacts all aspects of human activities. However there is neither any detailed definition nor a general and proper index for drought monitoring In the present study using the Drought indices SPI and RDI to monitor drought in 10 synoptic stations in the province were studied over a period of 24 years(1991-2010). After using panel data analysis of annual and seasonal drought tried to detecte effective the parameters above were measured using two indicators. Based on the results of monitoring Drought was found a severe drought that the 2008 in the province. Also, analyse of Panel data was show all six parameters mean of maximume tempretuer, mean of minimum tempreture, sun shine, precipitation, relative humidity and mean wind speed in 2 meters that to calculate the drought index RDI, not required to calculate Drought in time scale of annual and seasonal in 10 stations; due time scale, only of some these parameters are required. Based on SPI, precipitation is necessary for time scale annual and seasonal droghut

Role of the ubiquitin–proteasome system in nervous system function and disease : using C. elegans as a dissecting tool

In addition to its central roles in protein quality control, regulation of cell cycle, intracellular signaling, DNA damage response and transcription regulation, the ubiquitin– proteasome system (UPS) plays specific roles in the nervous system, where it contributes to precise connectivity through development, and later assures functionality by regulating a wide spectrum of neuron-specific cellular processes. Aberrations in this system have been implicated in the etiology of neurodevelopmental and neurodegenerative diseases. In this review, we provide an updated view on the UPS and highlight recent findings concerning its role in normal and diseased nervous systems. We discuss the advantages of the model organism Caenorhabditis elegans as a tool to unravel the major unsolved questions concerning this biochemical pathway and its involvement in nervous system function and dysfunction, and expose the new possibilities, using state-ofthe- art techniques, to assess UPS function using this model system.Fundação para a Ciência e a Tecnologia (FCT) - PTDC/SAU-GMG/ 101572/2008, PTDC/SAU-NMC/120144/2010, SFRH/BD/47963/200