Ethyl α-​phenylhydrazono-​2-​furanpropionate

The title compd. is orthorhombic, space group Pca21, with a 11.115(1)​, b 8.170(1)​, and c 15.341(1) Å; Z = 4 for dm = 1.290 and dc = 1.293. The structure was solved by direct methods and refined to an R of 0.041 for 1033 reflections. At. coordinates are given. The structure conforms to the non-​H-​bonded α form. The hydrazine moiety is planar with sp2 hybridization at the N and neighboring atoms. Intermol. N-​H...O hydrogen bonds link the mols. into chains along a

Life expectancy of white and non-white elite heavyweight boxers

Background: In post-industrial countries, ethnic minorities suffer poorer health and premature deaths. The present study examined ethnic differences in life expectancy and related features among elite heavyweight boxers. Methods: Dates of birth and death, anthropometry, and championship years were gathered from media archives for champions and challengers (never been a champion) between years 1889 and 2019. Cox regression adjusted for age at contest, nationality, BMI, champion/challenger status, and number of contests was used to assess survival. Results: All 237 boxers, 83 champions (37.3% whites) and 154 challengers (61.0% whites), who contested for heavyweight championships were identified. By 2019, 110 (75 whites, 34 non-whites) were known to have died. Non-white boxers died at an earlier age than whites boxers (mean ± SD = 59.8 ± 14.2 years versus 67.3 ± 16.4 years, p = 0.018) and had shorter survival: HR = 2.13 (95% CI = 1.4–3.3). Among non-white boxers, deaths were higher from neurological disorders: OR = 8.2 (95% CI = 1.3–13.5) and accidents: OR = 15.1 (95% CI = 2.3–98.2), while death from natural causes was lower: OR = 0.2 (95% CI = 0.03–0.8). After boxing careers, fewer non-white boxers had non-manual jobs (34.4% versus 71.8%) than manual (34.4% versus 19.7%) or were unemployed (28.1% versus 2.8%). Reported substance abuse was similar across ethnicity (8.0% versus 8.8%) but conviction rates were higher among non-white boxers (17.6%) than white (1.3%). Conclusions: Compared with white boxers, non-white boxers tend to die younger with excess neurological and accidental deaths, and they have lower social positions in later life. Sporting authorities should reappraise the wisdom of permitting head injuries in sport and monitor and support the health and wellbeing of sports men and women after retirement

Genome-Wide Association Study in BRCA1 Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk

BRCA1-associated breast and ovarian cancer risks can be modified by common genetic variants. To identify further cancer risk-modifying loci, we performed a multi-stage GWAS of 11,705 BRCA1 carriers (of whom 5,920 were diagnosed with breast and 1,839 were diagnosed with ovarian cancer), with a further replication in an additional sample of 2,646 BRCA1 carriers. We identified a novel breast cancer risk modifier locus at 1q32 for BRCA1 carriers (rs2290854, P = 2.7×10-8, HR = 1.14, 95% CI: 1.09-1.20). In addition, we identified two novel ovarian cancer risk modifier loci: 17q21.31 (rs17631303, P = 1.4×10-8, HR = 1.27, 95% CI: 1.17-1.38) and 4q32.3 (rs4691139, P = 3.4×10-8, HR = 1.20, 95% CI: 1.17-1.38). The 4q32.3 locus was not associated with ovarian cancer risk in the general population or BRCA2 carriers, suggesting a BRCA1-specific associat

The crystal and molecular structure of 6,6-diphenyl-3,3-diethyl-3-azabicyclo[3.1.0]hexane bromide monohydrate

Peer reviewed: YesNRC publication: Ye

X-ray crystallography of the Cl3[N(CH3)2]3P3N3 compounds. III. trans Nongeminal 2,4,6-trichloro-2,4,6-trisdimethylaminocyclotriphosphazatriene

Peer reviewed: YesNRC publication: Ye

Antioxidant activity of vitamin E and related phenols. Importance of stereoelectronic factors [11]

Peer reviewed: YesNRC publication: Ye