DMTs and Covid-19 severity in MS: a pooled analysis from Italy and France

We evaluated the effect of DMTs on Covid-19 severity in patients with MS, with a pooled-analysis of two large cohorts from Italy and France. The association of baseline characteristics and DMTs with Covid-19 severity was assessed by multivariate ordinal-logistic models and pooled by a fixed-effect meta-analysis. 1066 patients with MS from Italy and 721 from France were included. In the multivariate model, anti-CD20 therapies were significantly associated (OR = 2.05, 95%CI = 1.39–3.02, p < 0.001) with Covid-19 severity, whereas interferon indicated a decreased risk (OR = 0.42, 95%CI = 0.18–0.99, p = 0.047). This pooled-analysis confirms an increased risk of severe Covid-19 in patients on anti-CD20 therapies and supports the protective role of interferon

The Little World of Don Camillo - translate by UnaVincenzo Troubrige

160 hlm;ill;19 c

The Little World of Don Camillo

162hal.;20c

Don Camilo : (un mundo pequeño)

BNE, 07/02/2020, dá como data probable para esta edición 195

La vuelta de Don Camilo

No verso da portada: Título original Mondo piccolo "Don camilo e il suo gregge

Road Running After Gastric Bypass For Morbid Obesity: Rationale And Preliminary Results Of A New Protocol

Introduction: In recent years, the pandemic explosion of obesity has led to the definition of a pre-eminent therapeutic role for bariatric surgery, confining physical activity to a success parameter of surgery rather than a primary prevention measure. The aim of this study is to re-define a role for aerobic physical activity (road running) in strengthening the metabolic and psycho-social effects of bariatric surgery. Methods: 10 patients who underwent gastric bypass (RYGB) for morbid obesity were submitted to an intensive program of road running training. After a preparatory trimester, a six-month intensive training program started, aimed at completing a 10 km competition in September 2013. Inclusion criteria included age (<50), BMI (<35), suitability for sport activity and good compliance. A cohort of 10 patients excluded for logistical issues were enrolled as a control group. During the training period patients were submitted to biometrical measurements, sport performance tests (Cooper), and cardio-pulmonary, metabolic, nutritional and psychiatric evaluations. Results: Protocol compliance was 80%. After the preparatory phase mean weight significantly decreased (78.6 vs 86.8 kg, p: 0.03), slightly more than in the control group. Cooper test performance significantly increased for all the patients. Glycemic values remained normal during the entire period. All the participants (100%) expressed satisfaction at participating in the program. Conclusions: Road running seems to have an important supporting role in boosting bariatric surgery results. The utilization of monitorized and regulated training programs represents a fundamental prerequisite to achieving satisfactory results and adequate patient compliance