38 research outputs found
Effects of treatment modalities for Graves’ hyperthyroidism on Graves’ orbitopathy: a 2015 Italian Society of Endocrinology Consensus Statement
Get PDFSEPARATION OF N-0437 ENANTIOMERS BY RP-HPLC AFTER PRECOLUMN DERIVATIZATION WITH D(+)-GLUCURONIC ACID
No full textISOTOPIC SEPARATIONS OF THE DRUG N-0437 AND ITS DIASTEREOISOMERIC GLUCURONIDES BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY
No full textGLUCURONIDATION OF LABETALOL AT THE 2 HYDROXY POSITIONS BY BOVINE LIVER-MICROSOMES - ISOLATION, PURIFICATION, AND STRUCTURE ELUCIDATION OF THE GLUCURONIDES OF LABETALOL
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DEVELOPMENT OF A SENSITIVE RADIORECEPTOR ASSAY FOR OXYPHENONIUM IN PLASMA AND URINE
No full textA radioreceptor assay (RRA) for oxyphenonium has been developed. It is based on competition between [3H]dexetimide and oxyphenonium for binding to muscarinic receptors from calf striata. The RRA is optimized towards incubation medium and to extraction by ion pair formation with sodium picrate. At least 4 times 10−10 m of oxyphenonium is necessary to permit a reliable assay. This corresponds to a detection limit of drug of 2 ng ml−1 urine. After extraction, drug at 100 pg ml−1 of plasma can be estimated using 4 ml samples. The method is applicable to monitoring the drug and to the determination of its pharmacokinetics after therapeutic dosing. Urine levels can also be monitored
