. Role of FDG-PET to distinguish between septic and aseptic loosening in Hip prosthesis: a review of literature

Infection in prosthesis surgery is very dangerous because it changes the patient's prognosis. Differential diagnosis between septic and aseptic loosening is fundamental in order to apply the correct treatment. The correct diagnostic approach is still debated in literature. The aim of this study was to perform a review of literature evaluating positron emission tomography (PET) capacity to distinguish between septic and aseptic loosening in hip prosthesis. Research was done principally among medical archives. Five studies were selected which satisfied the required characteristics, and a weighted average of sensitivity and specificity of the different studies was determined. The fluorodeoxyglucose positron emission tomography (FDG-PET) sensitivity in individuating hip prosthesis infections was 82.8% and specificity was 87.3%. Positron emission tomography based on 2-fluoro-2-deoxy-D-glucose could be a valid option if research is able to find an uptake pattern specific for septic and aseptic loosening

Mazabraud's syndrome: a new case and review of the literature

The association between muscular myxomas and fibrous dysplasia is a rare condition known as Mazabraud's syndrome, as reported by Henschen (Verh Dtsch Ges Pathol 21:93-97, 1926) and Mazabraud A and Girard (Rev Rhum Mal Osteoartic 24(9-10):652-659, 1957). We report a case of a 32-year-old woman with multiple myxomas in her right thigh and monomelic fibrous dysplasia. A review of the international literature referring to 67 cases to date was carried out. The syndrome is characterised by the following features: females are twice as likely to be affected as males; the lower limbs are the most frequently affected, fibrous dysplasia is more common in the femur and the pelvis and myxomas in the quadriceps muscle; myxoma is multiple in more than 70% of cases. Although there has never been any continuity between tumours and bone lesions, a significant correlation between dysplastic bone and myxoma has been revealed

OUTCOME OF INTRALESIONAL CURETTAGE WITH ADJUVANTS FOR LOW-GRADE CHONDROSARCOMA OF THE BONE

Chondrosarcomas are malignant neoplasms that form an exclusively chondroid matrix. These generally slow-growing cartilage-based tumors most commonly occur in patients between 30 and 60 years old. In this article, we describe our retrospective clinical study, performed on 21 patients (11 males and 10 females) who were affected by conventional chondrosarcoma (Grade 1) and underwent surgery between 1997 and 2008. The patients’ average age was 45,5 (29 to 71 years old) with an average follow-up of 68,4 months. All low grade chondrosarcomas were treated with curettage, phenolization and reconstruction with acrylic bone cement. Assessment of the limb functional recovery in treated patients has been performed through the Musculoskeletal Tumour Society scoring system (MSTS). Patients’ average score six months after surgery was 76, 4% (between 61% and 87%) - low scores were reported in four patients following to complications (three fractures and one local recurrence). Another evalutation has been carried out through the MSTS scoring system at the end of our study, showing a value improvement, with an average score of 79.9% (between 63.3% and 88%). In conclusion, we see large intralesional curettage with chemical adjuvants (phenol and polimetilmetacrilate) as an effective treatment for low-grade chondrosarcoma of bones, allowing for a better patients’ compliance and a faster functional recovery. It is important, however, to prepare a surgical strategy according to the results of an accurate biopsy and a correct interpretation of the radiological imaging

The role of FDG-PET in distinguishing between septic and aseptic loosening in hip prosthesis: a review of literature

Infection in prosthesis surgery is very dangerous because it changes the patient’s prognosis. Differential diagnosis between septic and aseptic loosening is fundamental in order to apply the correct treatment. The correct diagnostic approach is still debated in literature. The aim of this study was to perform a review of literature evaluating positron emission tomography (PET) capacity to distinguish between septic and aseptic loosening in hip prosthesis. Research was done principally among medical archives. Five studies were selected which satisfied the required characteristics, and a weighted average of sensitivity and specificity of the different studies was determined. The fluorodeoxyglucose positron emission tomography (FDG-PET) sensitivity in individuating hip prosthesis infections was 82.8% and specificity was 87.3%. Positron emission tomography based on 2-fluoro-2-deoxy-D-glucose could be a valid option if research is able to find an uptake pattern specific for septic and aseptic loosening