164 research outputs found
How Membrane Curvature Drives the Up-Concentration of N-Ras Proteins to Ordered Lipid Domains : Correlation of In Vivo and In Vitro Experiments with Mean Field Theory Calculations and Coarse Grain Simulations
The Impact of Flavour Changing Neutral Gauge Bosons on B->X_s gamma
The branching ratio of the rare decay B->X_s gamma provides potentially
strong constraints on models beyond the Standard Model. Considering a general
scenario with new heavy neutral gauge bosons, present in particular in Z' and
gauge flavour models, we point out two new contributions to the B->X_s gamma
decay. The first one originates from one-loop diagrams mediated by gauge bosons
and heavy exotic quarks with electric charge -1/3. The second contribution
stems from the QCD mixing of neutral current-current operators generated by
heavy neutral gauge bosons and the dipole operators responsible for the B->X_s
gamma decay. The latter mixing is calculated here for the first time. We
discuss general sum rules which have to be satisfied in any model of this type.
We emphasise that the neutral gauge bosons in question could also significantly
affect other fermion radiative decays as well as non-leptonic two-body B
decays, epsilon'/epsilon, anomalous (g-2)_mu and electric dipole moments.Comment: 31 pages, 5 figures; version published on JHEP; added magic QCD
numbers for flavour-violating Z gauge boson contribution to B -> X_s gamm
Direct measurements of the effects of salt and surfactant on interaction forces between colloidal particles at water-oil interfaces
The forces between colloidal particles at a decane-water interface, in the
presence of low concentrations of a monovalent salt (NaCl) and of the
surfactant sodium dodecylsulfate (SDS) in the aqueous subphase, have been
studied using laser tweezers. In the absence of electrolyte and surfactant,
particle interactions exhibit a long-range repulsion, yet the variation of the
interaction for different particle pairs is found to be considerable. Averaging
over several particle pairs was hence found to be necessary to obtain reliable
assessment of the effects of salt and surfactant. It has previously been
suggested that the repulsion is consistent with electrostatic interactions
between a small number of dissociated charges in the oil phase, leading to a
decay with distance to the power -4 and an absence of any effect of electrolyte
concentration. However, the present work demonstrates that increasing the
electrolyte concentration does yield, on average, a reduction of the magnitude
of the interaction force with electrolyte concentration. This implies that
charges on the water side also contribute significantly to the electrostatic
interactions. An increase in the concentration of SDS leads to a similar
decrease of the interaction force. Moreover the repulsion at fixed SDS
concentrations decreases over longer times. Finally, measurements of three-body
interactions provide insight into the anisotropic nature of the interactions.
The unique time-dependent and anisotropic interactions between particles at the
oil-water interface allow tailoring of the aggregation kinetics and structure
of the suspension structure.Comment: Submitted to Langmui
Single Enzyme Studies Reveal the Existence of Discrete Functional States for Monomeric Enzymes and How They Are âSelectedâ upon Allosteric Regulation
Coronary Artery bypass grafting and/or valvular surgery in patients with previous pneumonectomy
Discrete Flavour Groups, \theta_13 and Lepton Flavour Violation
Discrete flavour groups have been studied in connection with special patterns
of neutrino mixing suggested by the data, such as Tri-Bimaximal mixing (groups
A4, S4...) or Bi-Maximal mixing (group S4...) etc. We review the predictions
for sin(\theta_13) in a number of these models and confront them with the
experimental measurements. We compare the performances of the different classes
of models in this respect. We then consider, in a supersymmetric framework, the
important implications of these flavour symmetries on lepton flavour violating
processes, like \mu -> e gamma and similar processes. We discuss how the
existing limits constrain these models, once their parameters are adjusted so
as to optimize the agreement with the measured values of the mixing angles. In
the simplified CMSSM context, adopted here just for indicative purposes, the
small tan(beta) range and heavy SUSY mass scales are favoured by lepton flavour
violating processes, which makes it even more difficult to reproduce the
reported muon g-2 discrepancy.Comment: 45 pages, 16 figures, 3 tables; V3 submitted to add an acknowledgment
to a Networ
Buttressing the Staple Line: A Randomized Comparison Between Staple-Line Reinforcement Versus No Reinforcement During Sleeve Gastrectomy
Membrane-mediated interactions
Interactions mediated by the cell membrane between inclusions, such as
membrane proteins or antimicrobial peptides, play important roles in their
biological activity. They also constitute a fascinating challenge for
physicists, since they test the boundaries of our understanding of
self-assembled lipid membranes, which are remarkable examples of
two-dimensional complex fluids. Inclusions can couple to various degrees of
freedom of the membrane, resulting in different types of interactions. In this
chapter, we review the membrane-mediated interactions that arise from direct
constraints imposed by inclusions on the shape of the membrane. These effects
are generic and do not depend on specific chemical interactions. Hence, they
can be studied using coarse-grained soft matter descriptions. We deal with
long-range membrane-mediated interactions due to the constraints imposed by
inclusions on membrane curvature and on its fluctuations. We also discuss the
shorter-range interactions that arise from the constraints on membrane
thickness imposed by inclusions presenting a hydrophobic mismatch with the
membrane.Comment: 38 pages, 10 figures, pre-submission version. In: Bassereau P., Sens
P. (eds) Physics of Biological Membranes. Springer, Cha
30-day morbidity and mortality of sleeve gastrectomy, Roux-en-Y gastric bypass and one anastomosis gastric bypass: a propensity score-matched analysis of the GENEVA data
Background: There is a paucity of data comparing 30-day morbidity and mortality of sleeve gastrectomy (SG), Roux-en-Y gastric bypass (RYGB), and one anastomosis gastric bypass (OAGB). This study aimed to compare the 30-day safety of SG, RYGB, and OAGB in propensity score-matched cohorts. Materials and methods: This analysis utilised data collected from the GENEVA study which was a multicentre observational cohort study of bariatric and metabolic surgery (BMS) in 185 centres across 42 countries between 01/05/2022 and 31/10/2020 during the Coronavirus Disease-2019 (COVID-19) pandemic. 30-day complications were categorised according to the ClavienâDindo classification. Patients receiving SG, RYGB, or OAGB were propensity-matched according to baseline characteristics and 30-day complications were compared between groups. Results: In total, 6770 patients (SG 3983; OAGB 702; RYGB 2085) were included in this analysis. Prior to matching, RYGB was associated with highest 30-day complication rate (SG 5.8%; OAGB 7.5%; RYGB 8.0% (p = 0.006)). On multivariate regression modelling, Insulin-dependent type 2 diabetes mellitus and hypercholesterolaemia were associated with increased 30-day complications. Being a non-smoker was associated with reduced complication rates. When compared to SG as a reference category, RYGB, but not OAGB, was associated with an increased rate of 30-day complications. A total of 702 pairs of SG and OAGB were propensity score-matched. The complication rate in the SG group was 7.3% (n = 51) as compared to 7.5% (n = 53) in the OAGB group (p = 0.68). Similarly, 2085 pairs of SG and RYGB were propensity score-matched. The complication rate in the SG group was 6.1% (n = 127) as compared to 7.9% (n = 166) in the RYGB group (p = 0.09). And, 702 pairs of OAGB and RYGB were matched. The complication rate in both groups was the same at 7.5 % (n = 53; p = 0.07). Conclusions: This global study found no significant difference in the 30-day morbidity and mortality of SG, RYGB, and OAGB in propensity score-matched cohorts
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