92 research outputs found

    p59fyn is associated with the development of hepatic steatosis due to chronic ethanol consumption

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    p59fyn, a protein tyrosine kinase belonging to the src-family, is involved in the regulatory mechanism of acute response to ethanol in the central nervous system. A previous report showed an association between src-family kinase activity and fatty acid oxidation, and it also reported that hepatic free fatty acid levels were low in Fyn−/− mice. We examined, using Fyn−/− mice whether Fyn is also involved in fatty acid metabolism and the development of pathological changes in the liver in response to chronic ethanol consumption. C57BL/6J Fyn−/− and Fyn+/+ mice were fed for 8 weeks with either a liquid diet comprising ethanol or one in which the calories from ethanol were replaced with carbohydrates. Chronic ethanol consumption for 8 weeks resulted in remarkable hepatic steatosis in Fyn+/+ mice but not in Fyn−/− mice. Chronic ethanol consumption induced a significant decrease in hepatic FFA and triglyceride levels in Fyn−/− mice. Levels of interleukin-6, which is associated with the enhancement of fatty acid oxidation, was also increased significantly in the livers of ethanol-fed Fyn−/− mice. The results suggest that Fyn is involved in the enhancement of fatty acid oxidation and the development of hepatic steatosis caused by chronic ethanol consumption

    The Evaluation and Follow-up of Retinal Angiomatous Proliferation by Optical Coherence Tomography with Simultaneous Fluorescein Angiography and Indocyanine Green Angiography

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    Ophthalmic Photographer's Society, Kastuhiko Fukui, Kazuomi Hanada, Hiromasa Igarashi, Akitoshi Yoshida, The Journal of ophthalmic photography, 29(2), 2007, 114-119 publisherRetinal angiomatous proliferation (RAP) is an intraretinal change resulting from retinal neovascularization. In advanced cases of RAP, retinal anastomosis occurs forming choroidal neovascularization (CNV), and differentiation from exudative age-related macular degeneration (AMD) becomes difficult. Treatment strategies differ between RAP and exudative AMD. We evaluated the combined use of optical coherence tomography (OCT) and simultaneous fundus fluorescein angiography (FFA) and indocyanine green angiography (ICG) in patients with RAP. In the early stages of the disease, the OCT was superior for determining the location of RAP lesions, follow-up evaluation of intraretinal edema during progression, and post-treatment evaluation after photocoagulation. In the advanced stage, OCT imaging was obscured by severe fibroplasia, and hemorrhage. In the late stages, simultaneous FFA and ICG helped with evaluation. Because some cases of RAP may progress into the advanced stage in a short period, combined findings from both OCT and simultaneous FFA and ICG are useful in providing a guide for the appropriate treatment

    Using optical coherence tomography for the morphologic evaluation of the posterior vitreous and retinal surface

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    Ophthalmic Photographer's Society, Fukui, Katsuhiko ; Hanada, Kazuomi ; Igarashi, Hiromasa ; Yoshida, Akitoshi, The Journal of ophthalmic photography, 30(2), pp.82-87, 2008. publisherOptical coherence tomography (OCT) is a technique that obtains cross-sectional images of tissue via a near-infrared, law-coherence light beam. The OCT constructs images by measuring the intensity and temporal delay of light reflected from the individual retinal layers and allows noninvasive evaluation of diseases affecting the posterior vitreous and retinal surface. The purpose of the current study was to investigate the usefulness of OCT in the morphologic assessment of such diseases. Using OCT, even a slight change in the refractive index can be visualized as a structural change. In addition, OCT can provide images of transparent structures such as the posterior vitreous body. In diseases affecting the posterior vitreous and retinal surface such as preretinal membranes, macular holes, and vitreomacular traction, the anatomic positional relationship between the posterior vitreous membrane and the macula is relevant

    The Usefulness of Fundus Photography with Red Light for the Diagnosis of Central Serous Chorioretinopathy

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    Ophthalmic Photographer's Society, Fukui, K; Yoshida, A; Kato, Y; Igarashi, H, The Journal of ophthalmic photography, 24(1), 2002, 36-39 publisherFundus photography using monochromatic red light is a well-known procedure. However, it is used infrequently because of the difficulty with interpretation. The authors studied the usefulness of red light fundus photography for the diagnosis of central serous chorioretinopathy (CSCR) using a Canon 60Z wide-angle fundus camera and a 23A Wratten Gelatin Filter. This method gave additional information from typical CSCR lesions compared to color photography. Our results suggest that fundus photography with red light is a simple and useful examination for CSCR and that it should be used in conjunction with color photography and fluorescein angiography
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