The Coexistence of Infection Spread Patterns in the Global Dynamics of COVID-19 Dissemination

The novel coronavirus SARS-CoV-2, commonly referred to as COVID-19, triggered the global pandemic. Although the nature of the international spread of infection is an important issue, extracting diffusion networks from observations is challenging because of its inherent complexity. In this paper, we investigate the process of infection worldwide, including time delays, based on global infection case data collected from January 3, 2020 to December 31, 2022. We approach the data with a complex Hilbert principal component analysis, which can consider not only the concurrent relationships between elements, but also the leading and lagging relationships. Then, we examine the interactions among countries by considering six factors: geography, population, GDP, stringency of countermeasures, vaccination rates, and government type. The results show two primary trends occurring in 2020 and in 2021-2022 and they interchange with each other. Specifically, European, highly populated, and democratic countries, i.e., countries with high mobility rates, show leading trends in 2020. In contrast, African and nondemocratic countries show leading trends in 2021-2022, followed by countries with high vaccination rates and advanced countermeasures. The results reveal that, although factors that increase infection risk lead to certain trends at the beginning of the pandemic, these trends dynamically changes over time due to socioeconomic factors, especially the introduction of countermeasures. The findings suggest that international efforts to promote countermeasures in developing countries can contribute to pandemic containment

Hepatic infarction following abdominal interventional procedures.

To clarify the incidence, background, and progress of hepatic infarction following interventional procedures, cases of hepatic infarction following interventional procedures at our department during the last decade were identified by reviewing the clinical records of 1982 abdominal angiography and interventional procedures and records of abdominal CT. Nine episodes (0.5%) in 8 patients were identified as hepatic infarction following an interventional procedure. Five episodes were preceded by embolization of the hepatic or celiac artery at emergency angiography for postoperative bleeding with hemorrhagic shock. Three episodes followed the elected interventional procedure for hepatocellular carcinoma, and the remaining episode occurred after 12 months of chemoinfusion through an indwelling catheter in the hepatic artery and portal vein. Hepatic arterial occlusion in all episodes and portal venous flow abnormality in 5 episodes were observed on angiography. Four patients whose liver function was initially impaired died of hepatic infarction, although the extent of the disease on CT did not appear to be related to the mortality. Multiple risk factors, including arterial insufficiency, were observed in each patient. The incidence of hepatic infarction following interventional procedures in this series was low but sometimes fatal, and occurred most frequently in emergency embolization in hemorrhagic shock.</p

Hierarchical communities in the walnut structure of the Japanese production network

This paper studies the structure of the Japanese production network, which includes one million firms and five million supplier-customer links. This study finds that this network forms a tightly-knit structure with a core giant strongly connected component (GSCC) surrounded by IN and OUT components constituting two half-shells of the GSCC, which we call a\textit{walnut} structure because of its shape. The hierarchical structure of the communities is studied by the Infomap method, and most of the irreducible communities are found to be at the second level. The composition of some of the major communities, including overexpressions regarding their industrial or regional nature, and the connections that exist between the communities are studied in detail. The findings obtained here cause us to question the validity and accuracy of using the conventional input-output analysis, which is expected to be useful when firms in the same sectors are highly connected to each other.Comment: 38 pages, 17 figure

Numerical analysis of bursting activity in an isolated pancreatic β-cell model

Pancreatic β-cells exhibit bursting electrical activity, which is correlated with insulin secretion. It has been reported that several ionic channels may contribute to the characteristic electrical activities of these cells but their mechanisms are still unclear. In this study, we examined how the characteristic electrical activity of isolated β-cells occurs. Using a simple mathematical model of pancreatic β-cells, we found that conductances of the voltage-sensitive mixed ion channel and voltage-sensitive potassium channel contribute to such electrical activity. In addition, we found that noise can play a key role in this activity. These results imply that the bursting electrical activity of pancreatic β-cells can be controlled by ionic conductances or noise. Such control enables medical application of β-cells in type II diabetes, wherein insulin secretion is difficult to control. Our findings may contribute to a novel treatment for type II diabetes