Heroin-piracetam mixture: suggested mechanisms of action and risks of misinterpretation for drug users

Piracetam is a positive allosteric modulator of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor that has been frequently used in the treatment of cognitive disorders. Press and internet reports indicate that the use of piracetam, as a heroin adulterant, has spread rapidly in some countries, especially in Asia and Europe. Its use, as adulterant, is believed to produce more profound desirable effects, while decreasing hangover. Recent surveys demonstrated that piracetam protects neurons from heroin-induced apoptosis. The protective role of this adulterating substance may be related to restoration of beta-endorphin levels and to its neuroprotective effects. The aim of this paper is to review the relevant literature and suggest the main hypothetical mechanisms that justify its use as a heroin adulterant, try to understand if its use could help people who want to come off heroin by reducing withdrawal symptoms and, finally, give useful information that permit us to understand why drug trafficking organisations started to use piracetam as heroin adulterant

Experimental Realization of Polarization Qutrits from Non-Maximally Entangled States

Based on a recent proposal [Phys. Rev. A 71, 062337 (2005)], we have experimentally realized two photon polarization qutrits by using non-maximally entangled states and linear optical transformations. By this technique high fidelity mutually unbiased qutrits are generated at a high brilliance level.Comment: RevTex, 8 pages, 6 figure

Hyperentanglement witness

A new criterium to detect the entanglement present in a {\it hyperentangled state}, based on the evaluation of an entanglement witness, is presented. We show how some witnesses recently introduced for graph states, measured by only two local settings, can be used in this case. We also define a new witness $W_3$ that improves the resistance to noise by increasing the number of local measurements.Comment: 6 pages, 2 figures, RevTex. v2: new title, minor changes in the explanation of the witness for hyperentangled states, more comments in the conclusions sectio

Asymmetric Architecture for Heralded Single Photon Sources

Single photon source represent a fundamental building block for optical implementations of quantum information tasks ranging from basic tests of quantum physics to quantum communication and high-resolution quantum measurement. In this paper we investigate the performance of a multiplexed system based on asymmetric configuration of multiple heralded single photon sources. {To compare the effectiveness of different designs we introduce a single-photon source performance index that is based on the value of single photon probability required to achieve a guaranteed signal to noise ratio.} The performance and scalability comparison with both currently existing multiple-source architectures and faint laser configurations reveals an advantage the proposed scheme offers in realistic scenarios. This analysis also provides insights on the potential of using such architectures for integrated implementation.Comment: 11 pages, 13 figure

Realization and characterization of a 2-photon 4-qubit linear cluster state

We report on the experimental realization of a 4-qubit linear cluster state via two photons entangled both in polarization and linear momentum. This state was investigated by performing tomographic measurements and by evaluating an entanglement witness. By use of this state we carried out a novel nonlocality proof, the so-called ``stronger two observer all versus nothing'' test of quantum nonlocality.Comment: 4 pages, 4 figure

Hyperentanglement of two photons in three degrees of freedom

A 6-qubit hyperentangled state has been realized by entangling two photons in three degrees of freedom. These correspond to the polarization, the longitudinal momentum and the indistinguishable emission produced by a 2-crystal system operating with Type I phase matching in the spontaneous parametric down conversion regime. The state has been characterized by a chained interferometric apparatus and its complete entangled nature has been tested by a novel witness criterium specifically introduced for hyperentangled states. The experiment represents the first realization of a genuine hyperentangled state with the maximum entanglement between the two particles allowed in the given Hilbert space.Comment: 4 pages, 2 figures, Revtex

Generation of time-bin entangled photons without temporal post-selection

We report on the implementation of a new interferometric scheme that allows the generation of photon pairs entangled in the time-energy degree of freedom. This scheme does not require any kind of temporal post-selection on the generated pairs and can be used even with lasers with short coherence time.Comment: RevTex, 6 pages, 8 figure

Multi-path entanglement of two photons

We present a novel optical device based on an integrated system of micro-lenses and single mode optical fibers. It allows to collect and direct into many modes two photons generated by spontaneous parametric down conversion. By this device multiqubit entangled states and/or multilevel qu-$d$it states of two photons, encoded in the longitudinal momentum degree of freedom, are created. The multi-path photon entanglement realized by this device is expected to find important applications in modern quantum information technology.Comment: 4 pages, 3 figures, revtex, revised versio

Optimizing Measurements Sequences for Quantum State Verification

We consider the problem of deciding whether a given state preparation, i.e., a source of quantum states, is accurate, namely produces states close to a target one within a prescribed threshold. We show that, when multiple measurements need to be used, the order of measurements is critical for quickly assessing accuracy. We propose and compare different strategies to compute optimal or suboptimal measurement sequences either relying solely on a priori information, i.e., the target state for state preparation, or actively adapting the sequence to the previously obtained measurements. Numerical simulations show that the proposed algorithms reduce significantly the number of measurements needed for verification, and indicate an advantage for the adaptive protocol especially assessing faulty preparations