Dynamic design of a cube-shaped satellite excited by launch vibrations

The objective of this Final Project is the structural design of a small cube–shaped satellite. Its primary structure should endure all launching vibrations. To fulfil that objective, a 3D Model of the satellite and a dynamic analysis must be done. The satellite has been designed as a multipurpose platform, so it can satisfy all possible client requirements in order to put different payloads into orbit. To begin with, a general satellite with an arbitrary payload has been designed with the future intention to adapt the current design to each client if necessary. To address the problem the following procedure has been used. First, and with a multi–platform CAD/CAM/CAE commercial software suite called CATIA (Computer Aided Three–Dimensional Interactive Application) a Computer Aided Design Model must be designed. Later, once the parameterized model is created, the engineering simulation software (CAE) ANSYS will be used to study the structural behaviour of the satellite during launch. The scope of this project is to design a multipurpose satellite bus that satisfies the conditions of the ASAP Document (see Section 6.1). That is, a satellite which can withstand all inertial forces and loads during launch in the 0–100 Hz spectrum, with a correctly aligned center of gravity, small enough moments of inertia, and with its natural frequencies above a certain value for each axis. The bus must fulfil the specifications given by the corresponding launch vehicle1 manufacturer, so to choose the launch vehicle, a comparative study has been made between the different options evaluating reliability, availability of the information offered and payload requirements. Once this study has been carried out, the most restrictive launcher has been selected. This has been done in order to be able to use a wider range of LV.Fraile Izquierdo, S.; Pila Vigalondo, A. (2014). Dynamic design of a cube-shaped satellite excited by launch vibrations. Universitat Politècnica de València. http://hdl.handle.net/10251/50741Archivo delegad

Preliminary Measurements of the Motion of Arcjet Current Channel Using Inductive Magnetic Probes

This paper covers the design and first measurements of non-perturbative, external inductive magnetic diagnostics for arcjet constrictors which can measure the motion of the arc current-channel. These measurements of arc motion are motivated by previous simulations using the ARC Heater Simulator (ARCHeS), which predicted unsteady arc motion due to the magnetic kink instability. Measurements of the kink instability are relevant to characterizing motion of the enthalpy profile of the arcjet, the arcjet operational stability, and electrode damage due to associated arc detachment events. These first measurements indicate $\pm4$ mm oscillations at 0.5-2 kHz of the current profile

3D Unsteady Model of Arc Heater Plasma Flow Using the ARC Heater Simulator (ARCHeS)

No abstract availabl

Protein Kinase C δ Regulates the Depletion of Actin at the Immunological Synapse Required for Polarized Exosome Secretion by T Cells

Multivesicular bodies (MVB) are endocytic compartments that enclose intraluminal vesicles (ILVs) formed by inward budding from the limiting membrane of endosomes. In T lymphocytes, ILVs are secreted as Fas ligand-bearing, pro-apoptotic exosomes following T cell receptor (TCR)-induced fusion of MVB with the plasma membrane at the immune synapse (IS). In this study we show that protein kinase C δ (PKCδ), a novel PKC isotype activated by diacylglycerol (DAG), regulates TCR-controlled MVB polarization toward the IS and exosome secretion. Concomitantly, we demonstrate that PKCδ-interfered T lymphocytes are defective in activation-induced cell death. Using a DAG sensor based on the C1 DAG-binding domain of PKCδ and a GFP-PKCδ chimera, we reveal that T lymphocyte activation enhances DAG levels at the MVB endomembranes which mediates the association of PKCδ to MVB. Spatiotemporal reorganization of F-actin at the IS is inhibited in PKCδ-interfered T lymphocytes. Therefore, we propose PKCδ as a DAG effector that regulates the actin reorganization necessary for MVB traffic and exosome secretion

Role of age and comorbidities in mortality of patients with infective endocarditis

[Purpose]: The aim of this study was to analyse the characteristics of patients with IE in three groups of age and to assess the ability of age and the Charlson Comorbidity Index (CCI) to predict mortality. [Methods]: Prospective cohort study of all patients with IE included in the GAMES Spanish database between 2008 and 2015.Patients were stratified into three age groups:<65 years,65 to 80 years,and ≥ 80 years.The area under the receiver-operating characteristic (AUROC) curve was calculated to quantify the diagnostic accuracy of the CCI to predict mortality risk. [Results]: A total of 3120 patients with IE (1327 < 65 years;1291 65-80 years;502 ≥ 80 years) were enrolled.Fever and heart failure were the most common presentations of IE, with no differences among age groups.Patients ≥80 years who underwent surgery were significantly lower compared with other age groups (14.3%,65 years; 20.5%,65-79 years; 31.3%,≥80 years). In-hospital mortality was lower in the <65-year group (20.3%,<65 years;30.1%,65-79 years;34.7%,≥80 years;p < 0.001) as well as 1-year mortality (3.2%, <65 years; 5.5%, 65-80 years;7.6%,≥80 years; p = 0.003).Independent predictors of mortality were age ≥ 80 years (hazard ratio [HR]:2.78;95% confidence interval [CI]:2.32–3.34), CCI ≥ 3 (HR:1.62; 95% CI:1.39–1.88),and non-performed surgery (HR:1.64;95% CI:11.16–1.58).When the three age groups were compared,the AUROC curve for CCI was significantly larger for patients aged <65 years(p < 0.001) for both in-hospital and 1-year mortality. [Conclusion]: There were no differences in the clinical presentation of IE between the groups. Age ≥ 80 years, high comorbidity (measured by CCI),and non-performance of surgery were independent predictors of mortality in patients with IE.CCI could help to identify those patients with IE and surgical indication who present a lower risk of in-hospital and 1-year mortality after surgery, especially in the <65-year group

Diccionario pictórico de Geografía e Historia de España

En portada: Consejería de Educación de la Embajada de España en PoloniaResumen basado en el de la publicaciónSe presenta una obra producto del trabajo de un grupo de docentes del Programa de Secciones Bilingües que la Consejería de Educación de la Embajada de España coordina en Polonia. Ésta pretende ser un recurso educativo más que facilite el Aprendizaje Integrado de Contenido y Lengua (AICLE) de las materias no lingüísticas del programa, en concreto Geografía e Historia de España, así como de la lengua española. Para ello, ofrece, por un lado, unas “tarjetas de vocabulario”, para ambas materias, en las que, para cada concepto básico recogido en los temas de los programas, se presentan tres tarjetas; una “tarjeta de concepto”, que contiene la palabra o significante; una “tarjeta de definición”, que contiene la descripción o significado; y una “tarjeta de imagen”, que contiene una fotografía o representación visual alusiva al concepto abordado. Por otro lado, incluye también unas fichas en las que los docentes han sistematizado algunas propuestas didácticas para utilizar las “tarjetas de vocabulario” en el aula.ES

COVID-19 in hospitalized HIV-positive and HIV-negative patients : A matched study

CatedresObjectives: We compared the characteristics and clinical outcomes of hospitalized individuals with COVID-19 with [people with HIV (PWH)] and without (non-PWH) HIV co-infection in Spain during the first wave of the pandemic. Methods: This was a retrospective matched cohort study. People with HIV were identified by reviewing clinical records and laboratory registries of 10 922 patients in active-follow-up within the Spanish HIV Research Network (CoRIS) up to 30 June 2020. Each hospitalized PWH was matched with five non-PWH of the same age and sex randomly selected from COVID-19@Spain, a multicentre cohort of 4035 patients hospitalized with confirmed COVID-19. The main outcome was all-cause in-hospital mortality. Results: Forty-five PWH with PCR-confirmed COVID-19 were identified in CoRIS, 21 of whom were hospitalized. A total of 105 age/sex-matched controls were selected from the COVID-19@Spain cohort. The median age in both groups was 53 (Q1-Q3, 46-56) years, and 90.5% were men. In PWH, 19.1% were injecting drug users, 95.2% were on antiretroviral therapy, 94.4% had HIV-RNA < 50 copies/mL, and the median (Q1-Q3) CD4 count was 595 (349-798) cells/μL. No statistically significant differences were found between PWH and non-PWH in number of comorbidities, presenting signs and symptoms, laboratory parameters, radiology findings and severity scores on admission. Corticosteroids were administered to 33.3% and 27.4% of PWH and non-PWH, respectively (P = 0.580). Deaths during admission were documented in two (9.5%) PWH and 12 (11.4%) non-PWH (P = 0.800). Conclusions: Our findings suggest that well-controlled HIV infection does not modify the clinical presentation or worsen clinical outcomes of COVID-19 hospitalization

Prosthetic Valve Candida spp. Endocarditis: New Insights Into Long-term Prognosis—The ESCAPE Study

International audienceBackground: Prosthetic valve endocarditis caused by Candida spp. (PVE-C) is rare and devastating, with international guidelines based on expert recommendations supporting the combination of surgery and subsequent azole treatment.Methods: We retrospectively analyzed PVE-C cases collected in Spain and France between 2001 and 2015, with a focus on management and outcome.Results: Forty-six cases were followed up for a median of 9 months. Twenty-two patients (48%) had a history of endocarditis, 30 cases (65%) were nosocomial or healthcare related, and 9 (20%) patients were intravenous drug users. "Induction" therapy consisted mainly of liposomal amphotericin B (L-amB)-based (n = 21) or echinocandin-based therapy (n = 13). Overall, 19 patients (41%) were operated on. Patients <66 years old and without cardiac failure were more likely to undergo cardiac surgery (adjusted odds ratios [aORs], 6.80 [95% confidence interval [CI], 1.59-29.13] and 10.92 [1.15-104.06], respectively). Surgery was not associated with better survival rates at 6 months. Patients who received L-amB alone had a better 6-month survival rate than those who received an echinocandin alone (aOR, 13.52; 95% CI, 1.03-838.10). "Maintenance" fluconazole therapy, prescribed in 21 patients for a median duration of 13 months (range, 2-84 months), led to minor adverse effects.Conclusion: L-amB induction treatment improves survival in patients with PVE-C. Medical treatment followed by long-term maintenance fluconazole may be the best treatment option for frail patients

Role of age and comorbidities in mortality of patients with infective endocarditis.

The aim of this study was to analyse the characteristics of patients with IE in three groups of age and to assess the ability of age and the Charlson Comorbidity Index (CCI) to predict mortality. Prospective cohort study of all patients with IE included in the GAMES Spanish database between 2008 and 2015.Patients were stratified into three age groups: A total of 3120 patients with IE (1327  There were no differences in the clinical presentation of IE between the groups. Age ≥ 80 years, high comorbidity (measured by CCI),and non-performance of surgery were independent predictors of mortality in patients with IE.CCI could help to identify those patients with IE and surgical indication who present a lower risk of in-hospital and 1-year mortality after surgery, especially in th