Pour que vive le patrimoine écrit : démocratiser son accès

Mémoire de fin d\u27étude du diplôme de conservateur promotion 26, portant sur la démocratisation du patrimoine écrit

Table ronde 2 | Enjeux professionnels et services aux usagers : services, usages, usagers

Table Ronde 2 organisée dans le cadre de la 5e biennale du numérique. Modération : Thomas Parisot (Institutonal Relations Officer, CAIRN) - Eléonore Alquier (Chef de département Collecte et Conservation, INA) - Valérie Brujas (directrice du réseau de la lecture publique, Vaulx-en-Velin) et Chryséis Bovagnet (Responsable du pôle numérique, Réseau de la lecture publique, Vaulx-en-Velin) - Tiphaine-Cécile Foucher (Adjointe au chef de produit data.bnf, BnF) - Benjamin Hennon (Fondateur du CEO Pythagoria

Recurrence Pattern of Cervical Cancer Based on the Platinum Sensitivity Concept: A Multi-Institutional Study from the FRANCOGYN Group

International audienceThe standard of care for patients with advanced cervical cancer (ACC) includes platinum-based chemotherapy. The concept of platinum sensitivity is a major prognostic factor for patients with ovarian cancer. The aim of this study was to validate the applicability of the platinum sensitivity concept to ACC patients, and to estimate its prognostic interest in terms of overall survival (OS) and pattern of recurrence (location, timing). Data of women with histologically proven FIGO 2019 stages IB3–IV ACC, treated between May 2000 and November 2017 with platinum-based regimens, were retrospectively abstracted from 12 institutions from the FRANCOGYN Group. Respective 3-year OSs were 52% (95% CI: 40.8%–66.8%), 21.6% (95% CI: 12.6%–37.2%), and 14.6% (95% CI: 4.2%–50.2%), in case of recurrence 18 months (p < 0.001). In multivariate analysis, platinum sensitivity status was a strong prognostic factor for OS after recurrence, independent of histological grade, lympho-vascular space involvement, final lymph node status, and treatment. Platinum sensitivity status may help to classify patients in three prognostic subgroups for OS after recurrence, and appears to be a strong prognostic factor correlated to the pattern of recurrenc

Biennale du numérique | Le web : vers une convergence des normes, formats, données ?

Pour cette édition 2019, le thème retenu est "Le web : vers une convergence des normes, formats, données ?" À l’heure de la généralisation des usages du web, les interventions de cette édition viseront à établir un panorama des enjeux, des conditions et des objectifs de la convergence des filières du livre vers le web et des nouvelles relations que cela induit entre filières. La Biennale du numérique s’adresse à tous les professionnels du livre : bibliothécaires, documentalistes, éditeurs, libraires, auteurs, mais aussi étudiants, chercheurs, membres d’associations, acteurs des collectivités territoriales et de l\u27État

Kidney Histopathology Can Predict Kidney Function in ANCA-Associated Vasculitides with Acute Kidney Injury Treated with Plasma Exchanges

International audienceBackground Data from the PEXIVAS trial challenged the role of plasma exchange (PLEX) in ANCA-associated vasculitides (AAV). We aimed to describe kidney biopsy from patients with AAV treated with PLEX, evaluate whether histopathologic findings could predict kidney function, and identify which patients would most benefit from PLEX. Methods We performed a multicenter, retrospective study on 188 patients with AAV and AKI treated with PLEX and 237 not treated with PLEX. The primary outcome was mortality or KRT at 12 months (M12). Results No significant benefit of PLEX for the primary outcome was found. To identify patients benefitting from PLEX, we developed a model predicting the average treatment effect of PLEX for an individual depending on covariables. Using the prediction model, 223 patients had a better predicted outcome with PLEX than without PLEX, and 177 of them had >5% increased predicted probability with PLEX compared with without PLEX of being alive and free from KRT at M12, which defined the PLEX-recommended group. Risk difference for death or KRT at M12 was significantly lower with PLEX in the PLEX-recommended group (−15.9%; 95% CI, −29.4 to −2.5) compared with the PLEX not recommended group (−4.8%; 95% CI, 14.9 to 5.3). Microscopic polyangiitis, MPO-ANCA, higher serum creatinine, crescentic and sclerotic classes, and higher Brix score were more frequent in the PLEX-recommended group. An easy to use score identified patients who would benefit from PLEX. The average treatment effect of PLEX for those with recommended treatment corresponded to an absolute risk reduction for death or KRT at M12 of 24.6%. Conclusions PLEX was not associated with a better primary outcome in the whole study population, but we identified a subset of patients who could benefit from PLEX. However, these findings must be validated before utilized in clinical decision making