The Calibration and Data Products of the Galaxy Evolution Explorer

We describe the calibration status and data products pertaining to the GR2 and GR3 data releases of the Galaxy Evolution Explorer (GALEX). These releases have identical pipeline calibrations that are significantly improved over the GR1 data release. GALEX continues to survey the sky in the Far Ultraviolet (FUV, ~154 nm) and Near Ultraviolet (NUV, ~232 nm) bands, providing simultaneous imaging with a pair of photon counting, microchannel plate, delay line readout detectors. These 1.25 degree field-of-view detectors are well-suited to ultraviolet observations because of their excellent red rejection and negligible background. A dithered mode of observing and photon list output pose complex requirements on the data processing pipeline, entangling detector calibrations and aspect reconstruction algorithms. Recent improvements have achieved photometric repeatability of 0.05 and 0.03 mAB in the FUV and NUV, respectively. We have detected a long term drift of order 1% FUV and 6% NUV over the mission. Astrometric precision is of order 0.5" RMS in both bands. In this paper we provide the GALEX user with a broad overview of the calibration issues likely to be confronted in the current release. Improvements are likely as the GALEX mission continues into an extended phase with a healthy instrument, no consumables, and increased opportunities for guest investigations.Comment: Accepted to the ApJS (a special GALEX issue

Ongoing Formation of Bulges and Black Holes in the Local Universe: New Insights from GALEX

We analyze a volume-limited sample of massive bulge-dominated galaxies with data from both the Sloan Digital Sky Survey and the Galaxy Evolution Explorer (GALEX) satellite. The galaxies have central velocity dispersions greater than 100 km/s and stellar surface mass densities that lie above the value where galaxies transition from actively star forming to passive systems. The sample is limited to redshifts 0.03<z<0.07. At these distances, the SDSS spectra sample the light from the bulge-dominated central regions of the galaxies. The GALEX NUV data provide high sensitivity to low rates of global star formation in these systems. Our sample of bulge-dominated galaxies exhibits a much larger dispersion in NUV-r colour than in optical g-r colour. Nearly all of the galaxies with bluer NUV-r colours are AGN. Both GALEX images and SDSS colour profiles demonstrate that the excess UV light is associated with an extended disk. We find that galaxies with red outer regions almost never have a young bulge or a strong AGN. Galaxies with blue outer regions have bulges and black holes that span a wide range in age and accretion rate. Galaxies with young bulges and strongly accreting black holes almost always have blue outer disks. Our suggested scenario is one in which the source of gas that builds the bulge and black hole is a low mass reservoir of cold gas in the disk.The presence of this gas is a necessary, but not sufficient condition for bulge and black hole growth. Some mechanism must transport this gas inwards in a time variable way. As the gas in the disk is converted into stars, the galaxies will turn red, but further gas infall can bring them back into the blue NUV-r sequence.(Abridged)Comment: 34 pages, 16 figures. Accepted for the GALEX special issue of ApJ

Clustering Properties of restframe UV selected galaxies I: the correlation length derived from GALEX data in the local Universe

We present the first measurements of the angular correlation function of galaxies selected in the far (1530 A) and near (2310 A) Ultraviolet from the GALEX survey fields overlapping SDSS DR5 in low galactic extinction regions. The area used covers 120 sqdeg (GALEX - MIS) down to magnitude AB = 22, yielding a total of 100,000 galaxies. The mean correlation length is ~ 3.7 \pm 0.6 Mpc and no significant trend is seen for this value as a function of the limiting apparent magnitude or between the GALEX bands. This estimate is close to that found from samples of blue galaxies in the local universe selected in the visible, and similar to that derived at z ~ 3 for LBGs with similar rest frame selection criteria. This result supports models that predict anti-biasing of star forming galaxies at low redshift, and brings an additional clue to the downsizing of star formation at z<1.Comment: Accepted for publication in GALEX Special ApJs, December 200

Clustering Properties of restframe UV selected galaxies II: Migration of Star Formation sites with cosmic time from GALEX and CFHTLS

We analyze the clustering properties of ultraviolet selected galaxies by using GALEX-SDSS data at z<0.6 and CFHTLS deep u' imaging at z=1. These datasets provide a unique basis at z< 1 which can be directly compared with high redshift samples built with similar selection criteria. We discuss the dependence of the correlation function parameters (r0, delta) on the ultraviolet luminosity as well as the linear bias evolution. We find that the bias parameter shows a gradual decline from high (b > 2) to low redshift (b ~ 0.79^{+0.1}_{-0.08}). When accounting for the fraction of the star formation activity enclosed in the different samples, our results suggest that the bulk of star formation migrated from high mass dark matter halos at z>2 (10^12 < M_min < 10^13 M_sun, located in high density regions), to less massive halos at low redshift (M_min < 10^12 M_sun, located in low density regions). This result extends the ``downsizing'' picture (shift of the star formation activity from high stellar mass systems at high z to low stellar mass at low z) to the dark matter distribution.Comment: Accepted for Publication in the Special GALEX Ap. J. Supplement, December 2007 Version with full resolution fig1 available at http://taltos.pha.jhu.edu/~sebastien/papers/Galex_p2.ps.g

Statistical Properties of the GALEX/SDSS matched source catalogs, and classification of the UV sources

We use the Galaxy Evolution Explorer (GALEX) Medium and All-Sky-Imaging Survey (MIS & AIS) data from the first public data release (GR1), matched to the Sloan Digital Sky Survey (SDSS) DR3 catalog, to perform source classification. The GALEX surveys provide photometry in far- and near-UV bands and the SDSS in five optical bands (u,g,r,i,z). The GR1/DR3 overlapping areas are 363[83]deg^2 for the GALEX AIS[MIS], for sources within the 0.5deg central area of the GALEX fields. Our sample covers mostly |b|>30deg galactic latitudes. We present statistical properties of the GALEX/SDSS matched sources catalog, containing >2x10^6 objects detected in at least one UV band. We classify the matched sources by comparing the seven-band photometry to model colors constructed for different classes of astrophysical objects. For sources with photometric errors <0.3 mag, the corresponding typical AB-magnitude limits are m_FUV~21.5, m_NUV~22.5 for AIS, and m_FUV~24, m_NUV~24.5 for MIS. At AIS depth, the number of Galactic and extragalactic objects are comparable, but the latter predominate in the MIS. Based on our stellar models, we estimate the GALEX surveys detect hot White Dwarfs throughout the Milky Way halo (down to a radius of 0.04 R_sun at MIS depth), providing an unprecedented improvement in the Galactic WD census. Their observed surface density is consistent with Milky Way model predictions. We also select low-redshift QSO candidates, extending the known QSO samples to lower magnitudes, and providing candidates for detailed z~1 follow-up investigations. SDSS optical spectra available for a large subsample confirm the classification for the photometrically selected candidates with 97% purity for single hot stars, ~45%(AIS)/31%(MIS) for binaries containing a hot star and a cooler companion, and about 85% for QSOs.Comment: 33 pages, 11 figures, accepted for the GALEX special issue of ApJS. For a version with full resolution figures see http://dolomiti.pha.jhu.edu/publgoto.htm

The UV-Optical Color Magnitude Diagram II: Physical Properties and Morphological Evolution On and Off of a Star-Forming Sequence

We use the UV-optical color magnitude diagram in combination with spectroscopic and photometric measurements derived from the SDSS spectroscopic sample to measure the distribution of galaxies in the local universe (z<0.25) and their physical properties as a function of specific star formation rate (SSFR) and stellar mass. Throughout this study our emphasis is on the properties of galaxies on and off of a local "star-forming sequence." We discuss how the physical characteristics of galaxies along this sequence are related to scaling relations typically derived for galaxies of different morphological types. We find, among other trends that our measure of the star formation rate surface density is nearly constant along this sequence. We discuss this result and implications for galaxies at higher redshift. For the first time, we report on measurements of the local UV luminosity function versus galaxy structural parameters as well as inclination. We also split our sample into disk-dominated and bulge-dominated subsamples using the i-band Sersic index and find that disk-dominated galaxies occupy a very tight locus in SSFR vs. stellar mass space while bulge-dominated galaxies display a much larger spread of SSFR at fixed stellar mass. A significant fraction of galaxies with SSFR and SF surface density above those on the "star-forming sequence" are bulge-dominated. We can use our derived distribution functions to ask whether a significant fraction of these galaxies may be experiencing a final episode of star formation (possibly induced by a merger or other burst), soon to be quenched, by determining whether this population can explain the growth rate of the non-star-forming galaxies on the "red sequence." (Abridged)Comment: 30 pages, 28 figures, scheduled to appear as part of the GALEX Special Ap.J.Suppl., December, 2007 (29 papers

Targeting the MAPK7/MMP9 axis for metastasis in primary bone cancer

From Springer Nature via Jisc Publications RouterHistory: received 2020-03-17, rev-recd 2020-05-24, accepted 2020-06-23, registration 2020-06-24, pub-electronic 2020-07-13, online 2020-07-13, pub-print 2020-08-13Publication status: PublishedFunder: Friends of RosieFunder: THRT, Big C, Paget's AssociationAbstract: Metastasis is the leading cause of cancer-related death. This multistage process involves contribution from both tumour cells and the tumour stroma to release metastatic cells into the circulation. Circulating tumour cells (CTCs) survive circulatory cytotoxicity, extravasate and colonise secondary sites effecting metastatic outcome. Reprogramming the transcriptomic landscape is a metastatic hallmark, but detecting underlying master regulators that drive pathological gene expression is a key challenge, especially in childhood cancer. Here we used whole tumour plus single-cell RNA-sequencing in primary bone cancer and CTCs to perform weighted gene co-expression network analysis to systematically detect coordinated changes in metastatic transcript expression. This approach with comparisons applied to data collected from cell line models, clinical samples and xenograft mouse models revealed mitogen-activated protein kinase 7/matrix metallopeptidase 9 (MAPK7/MMP9) signalling as a driver for primary bone cancer metastasis. RNA interference knockdown of MAPK7 reduces proliferation, colony formation, migration, tumour growth, macrophage residency/polarisation and lung metastasis. Parallel to these observations were reduction of activated interleukins IL1B, IL6, IL8 plus mesenchymal markers VIM and VEGF in response to MAPK7 loss. Our results implicate a newly discovered, multidimensional MAPK7/MMP9 signalling hub in primary bone cancer metastasis that is clinically actionable

Metabolic Networks of Sodalis glossinidius: A Systems Biology Approach to Reductive Evolution

Background: Genome reduction is a common evolutionary process affecting bacterial lineages that establish symbiotic or pathogenic associations with eukaryotic hosts. Such associations yield highly reduced genomes with greatly streamlined metabolic abilities shaped by the type of ecological association with the host. Sodalis glossinidius, the secondary endosymbiont of tsetse flies, represents one of the few complete genomes available of a bacterium at the initial stages of this process. In the present study, genome reduction is studied from a systems biology perspective through the reconstruction and functional analysis of genome-scale metabolic networks of S. glossinidius. Results: The functional profile of ancestral and extant metabolic networks sheds light on the evolutionary events underlying transition to a host-dependent lifestyle. Meanwhile, reductive evolution simulations on the extant metabolic network can predict possible future evolution of S. glossinidius in the context of genome reduction. Finally, knockout simulations in different metabolic systems reveal a gradual decrease in network robustness to different mutational events for bacterial endosymbionts at different stages of the symbiotic association. Conclusions: Stoichiometric analysis reveals few gene inactivation events whose effects on the functionality of S. glossinidius metabolic systems are drastic enough to account for the ecological transition from a free-living to hostdependent lifestyle. The decrease in network robustness across different metabolic systems may be associated with th

Targeting the MAPK7/MMP9 axis for metastasis in primary bone cancer

Metastasis is the leading cause of cancer related death. This multistage process involves contribution from both tumour cells and the tumour stroma to release metastatic cells into the circulation. Circulating tumour cells (CTCs) survive circulatory cytotoxicity, extravasate and colonise secondary sites effecting metastatic outcome. Reprogramming the transcriptomic landscape is a metastatic hallmark but detecting underlying master regulators that drive pathological gene expression is a key challenge, especially in childhood cancer. Here we used whole tumour plus single cell RNA sequencing in primary bone cancer and CTCs to perform weighted gene co-expression network analysis to systematically detect coordinated changes in metastatic transcript expression. This approach with comparisons applied to data collected from cell line models, clinical samples and xenograft mouse models revealed MAPK7/MMP9 signalling as a driver for primary bone cancer metastasis. RNAi knockdown of MAPK7 reduces proliferation, colony formation, migration, tumour growth, macrophage residency/polarisation and lung metastasis. Parallel to these observations were reduction of activated interleukins IL1B, IL6, IL8 plus mesenchymal markers VIM and VEGF in response to MAPK7 loss. Our results implicate a newly discovered, multidimensional MAPK7/MMP9 signalling hub in primary bone cancer metastasis that is clinically actionable

Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTIC‐HF: baseline characteristics and comparison with contemporary clinical trials

Aims: The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTIC‐HF) trial. Here we describe the baseline characteristics of participants in GALACTIC‐HF and how these compare with other contemporary trials. Methods and Results: Adults with established HFrEF, New York Heart Association functional class (NYHA) ≥ II, EF ≤35%, elevated natriuretic peptides and either current hospitalization for HF or history of hospitalization/ emergency department visit for HF within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokinetic‐guided dosing: 25, 37.5 or 50 mg bid). 8256 patients [male (79%), non‐white (22%), mean age 65 years] were enrolled with a mean EF 27%, ischemic etiology in 54%, NYHA II 53% and III/IV 47%, and median NT‐proBNP 1971 pg/mL. HF therapies at baseline were among the most effectively employed in contemporary HF trials. GALACTIC‐HF randomized patients representative of recent HF registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressure &lt; 100 mmHg (n = 1127), estimated glomerular filtration rate &lt; 30 mL/min/1.73 m2 (n = 528), and treated with sacubitril‐valsartan at baseline (n = 1594). Conclusions: GALACTIC‐HF enrolled a well‐treated, high‐risk population from both inpatient and outpatient settings, which will provide a definitive evaluation of the efficacy and safety of this novel therapy, as well as informing its potential future implementation