Analyse technico-écononomique multi-acteurs de la conception optimale d'un système de valorisation de chaleur fatale sur réseau de chaleur

This video was recorded as part of the international cycle of webinars in French and English: "Energy communities, self-production, self-consumption: frameworks, practices and tools" https://ce-ec.sciencesconf.org/. Cycle co-organised by the University Grenoble Alpes (CDP Eco-SESA Smart Energy in Districts) and the Plan Urbanisme Construction Architecture. It presents a method for simulating and optimising equipment - based on the OMEGALPES modular model - for the recovery of waste heat from an electro-intensive consumer (National Laboratory for Intense Magnetic Fields), taking into account the actors involved and their different areas of responsibility.Cette vidéo a été enregistrée dans le cadre du cycle international en langue français et anglaise de webinaires : "Communautés énergétiques, autoproduction, autoconsommation : cadrages, pratiques et outils" https://ce-ec.sciencesconf.org/. Cycle coorganisé par l'Université Grenoble Alpes (CDP Eco-SESA Smart Energy in Districts) et le Plan Urbanisme Constriction Architecture. Elle présente une méthode de simulation et d'optimisation - basée sur le modèle modulaire OMEGALPES - des équipements de récupération de chaleur fatale d'une installation électro-intensive (Laboratoire Nationale de Champs Magnétiques Intenses) prenant en compte les acteurs impliqués et leur différents périmètres de responsabilité

Towards a Digital Twin of Grenoble-Presqu'île: A Framework for District-Scale Digital Twin Development

International audienc

Energy- and exergy-based optimal designs of a low-temperature industrial waste heat recovery system in district heating

International audienceThis paper illustrates how the choice of indicators changes the design of a waste heat recovery system in district heating. A prospective system in Grenoble (France) aims to valorize waste heat from the French National Laboratory of Intense Magnetic Fields (LNCMI) by injecting it at 85 degrees C to the nearby district heating network. We optimize its design for three possible waste heat temperatures: 35 degrees C (current), 50 degrees C (viable) and 85 degrees C (innovative). As major components, the system includes a thermal storage (ranging from 10 MWh to 40 MWh) and may include a heat pump depending on the waste heat's temperature. Different optimizations are guided by two energetic indicators (one source-oriented, the other demand-oriented) and by the overall exergy efficiency. The system's annual performance is assessed through the Sankey and Grassman diagrams and compared between optimal designs. Yearly simulation included optimal management of the thermal storage, through mixed-integer linear programming. The demand-oriented optimal design suggests recovering waste heat at 35 degrees C with a heat pump and a 40-MWh storage, granting the highest coverage of residential needs (49%). On the other hand, the source-oriented optimal design suggests recovering waste heat at 85 degrees C without heat pump and with a 40-MWh storage, reaching the highest recovery of waste heat (55%). Exergy analysis supports the source-oriented design, as it reaches the highest global exergy efficiency (27%). Our prospective techno-economic and exergo-economic analyses should complement these results and may change some conclusions, especially regarding the storage capacity

Five-Year Changes in Inflammatory, Metabolic, and Oxidative Biomarkers and 10-Year Cardiovascular Disease Incidence: The REGICOR Cohort Study

Ischemic cardiovascular diseases (CVD) originate from an imbalance between atherosclerotic plaque formation, instability, and endothelial healing dynamics. Our aim was to examine the relationship between 5-year changes in inflammatory, metabolic, and oxidative biomarkers and 10-year CVD incidence in a population without previous CVD. This was a prospective cohort study of individuals aged 35–74 years (n = 419) randomly selected from 5263 REGICOR participants without CVD recruited in 2005. Biomarkers were measured at baseline and in 2010. Participants were followed up until 2020 for a composite CVD endpoint including coronary artery disease, stroke, and peripheral artery disease. We used Cox regression to analyze the effect of biomarker levels on the occurrence of the composite endpoint, adjusted for traditional CVD risk factors and baseline levels of each biomarker. Individuals with elevated IL-6 or insulin after 5 years had a higher independent risk of CVD at 10 years, compared to those with lower levels. Each rise of 1 pg/mL of IL-6 or 10 pg/mL of insulin increased the 10-year risk of a CVD event by 32% and 2%, respectively. Compared to a model with traditional CVD risk factors only, the inclusion of IL-6 and insulin improved continuous reclassification by 51%. Elevated serum levels of IL-6 and insulin were associated with a higher risk of CVD at 10 years, independently of traditional CVD risk factors

South-to-North gradient in lipid peroxidation in men with stable coronary artery disease in Europe

A South-to-North gradient across Europe exists for the incidence of coronary artery disease (CAD) rates. Low-density lipoprotein (LDL) oxidation is a hallmark of atherosclerosis and CAD development. The aim of our study was to determine whether differences exist in the degree of LDL oxidation in stable CAD patients from different regions of Europe. METHODS AND RESULTS: A cross-sectional multicentre study included 790 stable CAD male subjects aged 35-79 years (61.4 +/- 9.5) from six European countries in three regions by latitude: Northern (Finland and Sweden), Central (Germany), and Southern (Greece, Spain, and Italy). Plasma oxidized LDL (oxLDL) levels were determined. Alcohol intake and lipid profile were significantly associated with oxLDL. The Italian participants had the highest oxLDL levels. A sensitivity analysis showed the models yielded higher adjusted oxLDL values in Northern (63.8 U/L) than in Central (57.6 U/L) and Southern populations (56.5 U/L), P < 0.001, after excluding Italian subjects. The probability of Southern Europe scoring the lowest oxLDL levels was >71% in all fitted models. CONCLUSION: Our findings suggest a gradient in LDL oxidation from Southern to Northern Europe that consistently holds for all levels of LDL, except for Italy; this country displays the highest levels in Europe, for unknown reasons

South-to-North gradient in lipid peroxidation in men with stable coronary artery disease in Europe

Aims A South-to-North gradient across Europe exists for the incidence of coronary artery disease (CAD) rates. Low-density lipoprotein (LDL) oxidation is a hallmark of atherosclerosis and CAD development. The aim of our study was to determine whether differences exist in the degree of LDL oxidation in stable CAD patients from different regions of Europe. Methods and results A cross-sectional multicentre study included 790 stable CAD male subjects aged 35-79 years (61.4 +/- 9.5) from six European countries in three regions by latitude: Northern (Finland and Sweden), Central (Germany), and Southern (Greece, Spain, and Italy). Plasma oxidized LDL (oxLDL) levels were determined. Alcohol intake and lipid profile were significantly associated with oxLDL. The Italian participants had the highest oxLDL levels. A sensitivity analysis showed the models yielded higher adjusted oxLDL values in Northern (63.8 U/L) than in Central (57.6 U/L) and Southern populations (56.5 U/L), P < 0.001, after excluding Italian subjects. The probability of Southern Europe scoring the lowest oxLDL levels was > 71% in all fitted models. Conclusion Our findings suggest a gradient in LDL oxidation from Southern to Northern Europe that consistently holds for all levels of LDL, except for Italy; this country displays the highest levels in Europe, for unknown reasons