41 research outputs found
Climate Change and Extreme Weather Adaptation Options for Transportation Assets in the Bay Area Pilot Project
The Metropolitan Transportation Commission (MTC), the San Francisco Bay Conservation and Development Commission (BCDC), the California Department of Transportation, District 4 (Caltrans) and San Francisco Bay Area Rapid Transit District (BART) have partnered on a collaborative sub- regional pilot project to assess adaptation options for a subset of key transportation assets vulnerable to sea level rise in Alameda County. This study builds on the Adapting to Rising Tides: Transportation Vulnerability and Risk Assessment Pilot Project which was completed in 2011 and identified representative critical transportation assets vulnerable to sea level rise. Both projects were funded by the Federal Highway Administration. The first study developed detailed risk profiles for approximately 30 transportation assets including road, rail and transit. Having identified the risks, and in order to move from assessment to action, three focus areas within Alameda County containing \u2018core\u2019 transportation assets and \u2018adjacent\u2019 community assets were selected for further study to ensure a thorough understanding of their vulnerabilities. Once that enhanced vulnerability had been assessed, a set of detailed, representative adaptation strategies have been developed as potential solutions to protect key bridge, highway, transit and community assets from future inundation
Mindlessness Revisited: Sequential Request Techniques Foster Compliance by Draining Self-control Resources
The present research extends previous findings suggesting that sequential request techniques, such as the Foot-in-the-Door (FITD) or Door-in-the-Face (DITF) technique, are primarily effective under conditions conducive of mindlessness. We forward that this mindlessness may be the product of the influence technique itself. More specifically, based on the notion of self-control as a limited resource, we hypothesize that actively responding to the initial request-phase of a FITD-compliance gaining procedure drains the target of his/her self-regulatory resources, thus creating the mindlessness so often observed in social influence settings. This resource depletion opens the door for compliance with the target request. The results were in line with these expectations. More specifically, we observed that active responding to an initial request of a FITD technique reduced the availability of self-regulatory resources. This state of resource depletion mediated the effect of the technique on behavioral compliance. In addition, the results of this study ruled out the alternate explanation that the effects were attributable to mood or a general tendency for acquiescence
Recommended from our members
APRIL MONTHLY PROGRESS REPORT - THE PARTITIONING OF MAJOR, MINOR, AND TRACE ELEMENTS DURING SIMULATED IN-SITU OIL SHALE RETORTING
Recommended from our members
THE PARTITIONING OF MAJOR, MINOR, AND TRACE ELEMENTS DURING SIMULATED IN-SITU OIL SHALE RETORTING ~ FEBRUARY MONTHLY PROGRESS REPORT
Recommended from our members
THE PARTITIONING OF MAJOR, MINOR, AND TRACE ELEMENTS DURING SIMULATED IN-SITU OIL SHALE RETORTING
Recommended from our members
THE PARTITIONING OF MAJOR, MINOR, AND TRACE ELEMENTS DURING SIMULATED IN-SITU OIL SHALE RETORTING
Recommended from our members
THE PARTITIONING OF MAJOR, MINOR, AND TRACE ELEMENTS DURING SIMULATED IN-SITU OIL SHALE RETORTING
Bacteriophage treatment of intransigent diabetic toe ulcers: a case series
OBJECTIVE:
Diabetic foot ulcer (DFU) infections are a growing public health problem, with increasing prevalence, poor response to antibiotics and bacterial resistance to traditional antimicrobials leading to increased morbidity and mortality. Bacteriophages (phages), the viruses that target specific bacteria, are one option for addressing bacterial infections, especially where antibiotics fail. Of particular value is a class of virulent staphylococcal phages that hit almost all Staphylococcus aureus, including most methicillin-resistant Staphylococcus aureus (MRSA) strains. Here we report a continuous case series assessing the effectiveness of treating infected and poorly vascularised toe ulcers with exposed bone, after failure of recommended antibiotic therapy, using topically applied Staphylococcus aureus-specific phage.
METHOD:
This was a compassionate-use case series of nine patients with diabetes and poorly perfused toe ulcers containing culture-proven Staphylococcus aureus infected bone and soft tissue, who had responded poorly to recommended antibiotic therapy. Six representative cases are presented here. The only generally accepted other option in each case was toe amputation. Exposed portions of the infected phalanges were removed in three cases and left in place in two cases. One case presented as a micro-clot induced gangrene following vascular stenting. In this case, phage were used to prevent infection. The phage used was a commercially available fully sequenced preparation of staphylococcal phage Sb-1. Phage solution was applied topically to the ulcerations once weekly, following standard good wound care. The amount of phage solution applied varied from 0.1 to 0.5 cc depending on volume and area of the ulceration.
RESULTS:
All infections responded to the phage applications and the ulcers healed in an average of seven weeks with infected bone debridement. One ulcer, where vascularity was extremely poor and bone was not removed to preserve hallux function, required 18 weeks of treatment. In the case of the toe with the micro-clot gangrene, the toe was salvaged and healed in seven weeks without complications.
CONCLUSION:
Topical application of a staph mono-phage preparation can be used successfully to treat infected toe ulcerations with bone involvement, despite very poor vascularity and failure of antibiotic treatment. The success within this small series provides the groundwork for controlled clinical trials of staph phage for diabetic foot infections.status: publishe
Recommended from our members
Quality Assurance and Food Safety: Trainer's Reference
73 pp.Originally developed in Iowa and adapted for Arizona. Arizona Youth Livestock Quality Assurance Member Manual; Arizona Youth Livestock Quality Assurance Activity Guide.This trainer's reference is for use in implementing the youth livestock quality assurance program. The curriculum is designed to provide youth and adults with a better understanding of the risks involved in the food production industry, better understand the Good Production Practices (GPP's) that can help them produce a safer product and therefore, implement these GPP's in their own livestock production system