High prevalence of extrapyramidal signs and symptoms in a group of Italian dental technicians

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Access to care issues adversely affect breast cancer patients in Mexico: oncologists’ perspective

Background: Despite recently implemented access to care programs, Mexican breast cancer (BC) mortality rates remain substantially above those in the US. We conducted a survey among Mexican Oncologists to determine whether practice patterns may be responsible for these differences. Methods: A web-based survey was sent to 851 oncologists across Mexico using the Vanderbilt University REDCap database. Analyses of outcomes are reported using exact and binomial confidence bounds and tests. Results: 138 participants (18.6% of those surveyed) from the National capital and 26 Mexican states, responded. Respondents reported that 58% of newly diagnosed BC patients present with stage III-IV disease; 63% undergo mastectomy, 52% axillary lymph node dissection (ALND) and 48% sentinel lymph node biopsy (SLNB). Chemotherapy is recommended for tumors > 1 cm (89%), positive nodes (86.5%), triple-negative (TN) (80%) and HER2 positive tumors (58%). Trastuzumab is prescribed in 54.3% and 77.5% for HER2 1 cm tumors, respectively. Tamoxifen is indicated for premenopausal hormone receptor (HR) positive tumors in 86.5% of cases and aromatase inhibitors (AI’s) for postmenopausal in 86%. 24% of physicians reported treatment limitations, due to delayed or incomplete pathology reports and delayed or limited access to medications. Conclusions: Even though access to care programs have been recently applied nationwide, women commonly present with advanced BC, leading to increased rates of mastectomy and ALND. Mexican physicians are dissatisfied with access to appropriate medical care. Our survey detects specific barriers that may impact BC outcomes in Mexico and warrant further investigation. Electronic supplementary material The online version of this article (doi:10.1186/1471-2407-14-658) contains supplementary material, which is available to authorized users

SGAS 143845.1+145407: A Big, Cool Starburst at Redshift 0.816

We present the discovery and a detailed multi-wavelength study of a strongly-lensed luminous infrared galaxy at z=0.816. Unlike most known lensed galaxies discovered at optical or near-infrared wavelengths this lensed source is red, r-Ks = 3.9 [AB], which the data presented here demonstrate is due to ongoing dusty star formation. The overall lensing magnification (a factor of 17) facilitates observations from the blue optical through to 500micron, fully capturing both the stellar photospheric emission as well as the re-processed thermal dust emission. We also present optical and near-IR spectroscopy. These extensive data show that this lensed galaxy is in many ways typical of IR-detected sources at z~1, with both a total luminosity and size in accordance with other (albeit much less detailed) measurements in samples of galaxies observed in deep fields with the Spitzer telescope. Its far-infrared spectral energy distribution is well-fit by local templates that are an order of magnitude less luminous than the lensed galaxy; local templates of comparable luminosity are too hot to fit. Its size (D~7kpc) is much larger than local luminous infrared galaxies, but in line with sizes observed for such galaxies at z~1. The star formation appears uniform across this spatial scale. In this source, the luminosity of which is typical of sources that dominate the cosmic infrared background, we find that star formation is spatially extended and well organised, quite unlike the compact merger-driven starbursts which are typical for sources of this luminosity at z~0.Comment: 18 pages, 10 figure

Bivariate Interval-Censored Failure Time Data

This is the peer reviewed version of the following article: Cook, R. J., Zeng, L. and Lee, K.-A. (2008), A Multistate Model for Bivariate Interval-Censored Failure Time Data. Biometrics, 64: 1100–1109. doi: 10.1111/j.1541-0420.2007.00978.x, which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1111/j.1541-0420.2007.00978.x/abstract. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving. The definitive version is available at http://onlinelibrary.wiley.com/doi/10.1111/j.1541-0420.2007.00978.x/abstract’Interval-censored life-history data arise when the events of interest are only detectable at periodic assessments. When interest lies in the occurrence of two such events, bivariate-interval censored event time data are obtained. We describe how to fit a four-state Markov model useful for characterizing the association between two interval-censored event times when the assessment times for the two events may be generated by different inspection processes. The approach treats the two events symmetrically and enables one to fit multiplicative intensity models that give estimates of covariate effects as well as relative risks characterizing the association between the two events. An expectation-maximization (EM) algorithm is described for estimation in which the maximization step can be carried out with standard software. The method is illustrated by application to data from a trial of HIV patients where the events are the onset of viral shedding in the blood and urine among individuals infected with cytomegalovirus.Natural Sciences and Engineering Research Council of Canada (RGPIN 155849); Canadian Institutes for Health Research (FRN 13887); Canada Research Chair (Tier 1) – CIHR funded (950-226626

A Strong-Lensing Model for the WMDF JWST/GTO Very Rich Cluster Abell 1489

We present a first strong-lensing model for the galaxy cluster RM J121218.5+273255.1 ($z=0.35$; hereafter RMJ1212; also known as Abell 1489). This cluster is amongst the top 0.1\% richest clusters in the redMaPPer catalog; it is significantly detected in X-ray and through the Sunyaev-Zel'dovich effect in ROSAT and \emph{Planck} data, respectively; and its optical luminosity distribution implies a very large lens, following mass-to-light scaling relations. Based on these properties it was chosen for the Webb Medium Deep Fields (WMDF) JWST/GTO program. In preparation for this program, RMJ1212 was recently imaged with GMOS on Gemini North and in seven optical and near-infrared bands with the \emph{Hubble Space Telescope}. We use these data to map the inner mass distribution of the cluster, uncovering various sets of multiple images. We also search for high-redshift candidates in the data, as well as for transient sources. We find over a dozen high-redshift ($z\gtrsim6$) candidates based on both photometric redshift and the dropout technique. No prominent ($\gtrsim5 \sigma$) transients were found in the data between the two HST visits. Our lensing analysis reveals a relatively large lens with an effective Einstein radius of $\theta_{E}\simeq32\pm3''$ ($z_{s}=2$), in broad agreement with the scaling-relation expectations. RMJ1212 demonstrates that powerful lensing clusters can be selected in a robust and automated way following the light-traces-mass assumption.Comment: 17 pages, 6 figures, 2 tables; To be submitte

Bostonia: The Boston University Alumni Magazine. Volume 23

Founded in 1900, Bostonia magazine is Boston University's main alumni publication, which covers alumni and student life, as well as university activities, events, and programs

Home Telehealth Uptake and Continued Use Among Heart Failure and Chronic Obstructive Pulmonary Disease Patients: a Systematic Review

Background Home telehealth has the potential to benefit heart failure (HF) and chronic obstructive pulmonary disease (COPD) patients, however large-scale deployment is yet to be achieved. Purpose The aim of this review was to assess levels of uptake of home telehealth by patients with HF and COPD and the factors that determine whether patients do or do not accept and continue to use telehealth. Methods This research performs a narrative synthesis of the results from included studies. Results Thirty-seven studies met the inclusion criteria. Studies that reported rates of refusal and/or withdrawal found that almost one third of patients who were offered telehealth refused and one fifth of participants who did accept later abandoned telehealth. Seven barriers to, and nine facilitators of, home telehealth use were identified. Conclusions Research reports need to provide more details regarding telehealth refusal and abandonment, in order to understand the reasons why patients decide not to use telehealth

Dilaton Gravity in Two Dimensions

The study of general two dimensional models of gravity allows to tackle basic questions of quantum gravity, bypassing important technical complications which make the treatment in higher dimensions difficult. As the physically important examples of spherically symmetric Black Holes, together with string inspired models, belong to this class, valuable knowledge can also be gained for these systems in the quantum case. In the last decade new insights regarding the exact quantization of the geometric part of such theories have been obtained. They allow a systematic quantum field theoretical treatment, also in interactions with matter, without explicit introduction of a specific classical background geometry. The present review tries to assemble these results in a coherent manner, putting them at the same time into the perspective of the quite large literature on this subject.Comment: 144 pages, 16 figures; v2,v3: added refs. and corrected typos, v4: added 2 refs. and corrected typos (published version), v5: added note with some relevant refs., v6: diligent students found still a couple of typos, added 1 ref., v7: last update from Vienna (a couple of typos), v8: Leipzig edition (a dozen typos), v9: MIT edition (4 typos, 1 ref.