214 research outputs found
Nucleation in binary polymer blends: Effects of adding diblock copolymers
The effects of adding AB diblock copolymers to A/B binary blends on the structure and thermodynamics of critical nuclei are studied using the self-consistent field theory. At a fixed ratio of the amount of the two homopolymers, depending on the degree of polymerization and composition of the diblocks, their addition to the blends can either increase or decrease the nucleation free energy barrier relative to the pure A/B blends. The qualitative trend can be deduced from the shift in the coexistence boundary and the spinodal. The distribution of diblock copolymers in critical nuclei depends on the composition of the diblocks and the quench depth. Near the coexistence, symmetric diblocks exhibit surfactant behavior, being highly concentrated on the interface of the critical nuclei. Near the spinodal, they act more like co-solvent with a relatively uniform distribution
Progenitor/Stem Cell Engineering for Treatment of Ischemic Heart Diseases: Therapeutic Potentials and Challenges
Adsorption and desorption characteristics of arsenic onto ceria nanoparticles
The rapid increase in the use of engineered nanoparticles [ENPs] has resulted in an increasing concern over the potential impacts of ENPs on the environmental and human health. ENPs tend to adsorb a large variety of toxic chemicals when they are emitted into the environment, which may enhance the toxicity of ENPs and/or adsorbed chemicals. The study was aimed to investigate the adsorption and desorption behaviors of arsenic on ceria NPs in aqueous solution using batch technique. Results show that the adsorption behavior of arsenic on ceria NPs was strongly dependent on pH and independent of ionic strength, indicating that the electrostatic effect on the adsorption of these elements was relatively not important compared to surface chemical reactions. The adsorption isotherms fitted very well to both the Langmuir and Freundlich models. The thermodynamic parameters (ΔH0, ΔS0, and ΔG0) for the adsorption of arsenic were determined at three different temperatures of 283, 303, and 323 K. The adsorption reaction was endothermic, and the process of adsorption was favored at high temperature. The desorption data showed that desorption hysteresis occurred at the initial concentration studied. High adsorption capacity of arsenic on ceria NPs suggests that the synergistic effects of ceria NPs and arsenic on the environmental systems may exist when they are released into the environment
Ghost on the Shell: An Expressive Representation of General 3D Shapes
The creation of photorealistic virtual worlds requires the accurate modeling
of 3D surface geometry for a wide range of objects. For this, meshes are
appealing since they 1) enable fast physics-based rendering with realistic
material and lighting, 2) support physical simulation, and 3) are
memory-efficient for modern graphics pipelines. Recent work on reconstructing
and statistically modeling 3D shape, however, has critiqued meshes as being
topologically inflexible. To capture a wide range of object shapes, any 3D
representation must be able to model solid, watertight, shapes as well as thin,
open, surfaces. Recent work has focused on the former, and methods for
reconstructing open surfaces do not support fast reconstruction with material
and lighting or unconditional generative modelling. Inspired by the observation
that open surfaces can be seen as islands floating on watertight surfaces, we
parameterize open surfaces by defining a manifold signed distance field on
watertight templates. With this parameterization, we further develop a
grid-based and differentiable representation that parameterizes both watertight
and non-watertight meshes of arbitrary topology. Our new representation, called
Ghost-on-the-Shell (G-Shell), enables two important applications:
differentiable rasterization-based reconstruction from multiview images and
generative modelling of non-watertight meshes. We empirically demonstrate that
G-Shell achieves state-of-the-art performance on non-watertight mesh
reconstruction and generation tasks, while also performing effectively for
watertight meshes.Comment: Technical Report (26 pages, 16 figures, Project Page:
https://gshell3d.github.io/
Genetic risk, adherence to healthy lifestyle and acute cardiovascular and thromboembolic complications following SARS-COV-2 infection
Current understanding of determinants for COVID-19-related cardiovascular and thromboembolic (CVE) complications primarily covers clinical aspects with limited knowledge on genetics and lifestyles. Here, we analysed a prospective cohort of 106,005 participants from UK Biobank with confirmed SARS-CoV-2 infection. We show that higher polygenic risk scores, indicating individual's hereditary risk, were linearly associated with increased risks of post-COVID-19 atrial fibrillation (adjusted HR 1.52 [95% CI 1.44 to 1.60] per standard deviation increase), coronary artery disease (1.57 [1.46 to 1.69]), venous thromboembolism (1.33 [1.18 to 1.50]), and ischaemic stroke (1.27 [1.05 to 1.55]). These genetic associations are robust across genders, key clinical subgroups, and during Omicron waves. However, a prior composite healthier lifestyle was consistently associated with a reduction in all outcomes. Our findings highlight that host genetics and lifestyle independently affect the occurrence of CVE complications in the acute infection phrase, which can guide tailored management of COVID-19 patients and inform population lifestyle interventions to offset the elevated cardiovascular burden post-pandemic.</p
Prevalence and risk factors of hepatitis C among former blood donors in rural China
SummaryBackgroundIllegal commercial plasma and blood donation activities in the late 1980s and early 1990s caused a large number of hepatitis C virus (HCV) infections in rural areas of China.MethodsA cross-sectional survey was carried out in 2008, in which all residents in a former blood donation village in rural Hebei Province were invited for a questionnaire interview and testing for HCV antibodies. Questionnaires were administered to collect information about their personal status and commercial blood donation history, and HCV antibodies were tested by enzyme immunoassay.ResultsOf 520 villagers who participated in the interviews, 236 (45.4%) reported a history of selling whole blood or plasma. HCV seropositivity was confirmed in 148/520 (28.5%) interviewees and 101/236 (42.8%) former commercial plasma and blood donors. Selling plasma was the strongest independent predictor of HCV seropositivity (p=0.0037). Past history of an operation was also independently associated with HCV infection (p=0.0270).ConclusionsUnsafe practices during illegal plasma donation led to a high risk of HCV seropositivity for donors during the late 1980s and early 1990s. Many infected people suffered chronic hepatitis from that time onwards and urgently needed treatment and care
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