Icarus and status of Liquid-Argon technology

ICARUS-T600 at the INFN-LNGS Gran Sasso Laboratory is the first underground large-mass Liquid-Argon TPC: exposed to the CNGS neutrino beam from CERN, it has been taking data since May 2010. Thanks to its excellent resolution and 3D imaging, it allows an unprecedented event visualization quality combined with a good calorimetric reconstruction and the electronic event processing. After a first commissioning phase, it has started an interesting physics program, ranging from νμ → ντ oscillation search in appearance to matter stability study, thus demonstrating the feasibility and effectiveness of the Liquid-Argon TPC technique. Furthermore, ICARUS-T600 represents a major milestone towards the realization of much larger Liquid-Argon detectors for future rare events physics. The idea to use a LAr-TPC experiment at a refurbished CERN-PS neutrino beam is presented as a possible solution to the sterile neutrino puzzle

Fifty Years On

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Effects of gradual discontinuation of selective serotonin reuptake inhibitors in panic disorder with agoraphobia.

The aim of this investigation was to explore the prevalence and features of discontinuation syndromes ensuing with gradual tapering of selective serotonin reuptake inhibitors (SSRIs), in optimal clinical conditions in patients with panic disorder and agoraphobia. Twenty-six consecutive outpatients met the DSM-IV criteria for panic disorder and agoraphobia while taking SSRIs. Twenty remitted upon behavioural treatment. Antidepressant drugs were then tapered at the slowest possible pace and with appropriate patient education. Patients were assessed with the Discontinuation-Emergent Signs and Symptoms (DESS) checklist 2 wk, 1 month and 1 yr after discontinuation. Nine of the 20 patients (45%) experienced a discontinuation syndrome, which subsided within a month in all but three patients who had been taking paroxetine for a long time. Discontinuation syndromes appeared to be fairly common even when performed with slow tapering and during clinical remission. In some cases disturbances persisted for months after discontinuation

Las polaridades del bienestar psicológico y su respuesta al tratamiento

An increasing number of investigations in the positive psychology area has suggested the benefits of improving well-being and positivity. However, observations from clinical domains raised some concerns on the effectiveness and utility of such interventions, because excessively elevated levels in positive domains could become detrimental and impede flourishing. The aim of this article is to describe these polarities in well-being and to suggest specific therapeutic strategies to promote flourishing and resilience. Well-being therapy (WBT) is a psychotherapeutic technique based on Ryff's conceptual model, that has been developed and tested in a number of randomized controlled trials. The differential technical characteristics and indications of WBT are described, with special reference to the promotion of an individualized and balanced path to achieve optimal human functioning, avoiding the polarities in positive psychological dimensions. Un número creciente de investigaciones en el área de la Psicología positiva sugiere que incrementar el bienestar y la positividad conlleva beneficios. Sin embargo, observaciones del ámbito clínico han suscitado algunas cautelas sobre la efectividad y utilidad de dichas intervenciones ya que niveles excesivamente elevados en los dominios positivos pudieran ser perjudiciales e impide el florecimiento. El objetivo de este artículo es describir estas polaridades en el bienestar y sugerir estrategias terapéuticas para promover el florecimiento y la resiliencia. La terapia del bienestar (TB) es una técnica de psicoterapia, basada en el modelo conceptual de Ryff, que ha sido desarrollada y sometida a prueba en una serie de ensayos clínicos aleatorizados. Se describen las características técnicas diferenciales y las indicaciones de la TB, con especial referencia a la promoción de una vía individualizada y equilibrada para conseguir un funcionamiento humano óptimo, evitando las polaridades en las dimensiones psicológicas positivas

Nonergodic behavior of the clean Bose-Hubbard chain

We study ergodicity breaking in the clean Bose-Hubbard chain for small hopping strength. We see the existence of a non-ergodic regime by means of indicators as the half-chain entanglement entropy of the eigenstates, the average level spacing ratio, {the properties of the eigenstate-expectation distribution of the correlation and the scaling of the Inverse Participation Ratio averages.} We find that this ergodicity breaking {is different from many-body localization} because the average half-chain entanglement entropy of the eigenstates obeys volume law. This ergodicity breaking appears unrelated to the spectrum being organized in quasidegenerate multiplets at small hopping and finite system sizes, so in principle it can survive also for larger system sizes. We find that some imbalance oscillations in time which could mark the existence of a glassy behaviour in space are well described by the dynamics of a single symmetry-breaking doublet and {quantitatively} captured by a perturbative effective XXZ model. We show that the amplitude of these oscillations vanishes in the large-size limit. {Our findings are numerically obtained for systems with $L < 12$. Extrapolations of our scalings to larger system sizes should be taken with care, as discussed in the paper.Comment: 18 pages, 13 figures, extensively revised version published in Physical Review B, Eq. (21) in the correct for

Social contact structures and time use patterns in the Manicaland Province of Zimbabwe.

BACKGROUND: Patterns of person-to-person contacts relevant for infectious diseases transmission are still poorly quantified in Sub-Saharan Africa (SSA), where socio-demographic structures and behavioral attitudes are expected to be different from those of more developed countries. METHODS AND FINDINGS: We conducted a diary-based survey on daily contacts and time-use of individuals of different ages in one rural and one peri-urban site of Manicaland, Zimbabwe. A total of 2,490 diaries were collected and used to derive age-structured contact matrices, to analyze time spent by individuals in different settings, and to identify the key determinants of individuals' mixing patterns. Overall 10.8 contacts per person/day were reported, with a significant difference between the peri-urban and the rural site (11.6 versus 10.2). A strong age-assortativeness characterized contacts of school-aged children, whereas the high proportion of extended families and the young population age-structure led to a significant intergenerational mixing at older ages. Individuals spent on average 67% of daytime at home, 2% at work, and 9% at school. Active participation in school and work resulted the key drivers of the number of contacts and, similarly, household size, class size, and time spent at work influenced the number of home, school, and work contacts, respectively. We found that the heterogeneous nature of home contacts is critical for an epidemic transmission chain. In particular, our results suggest that, during the initial phase of an epidemic, about 50% of infections are expected to occur among individuals younger than 12 years and less than 20% among individuals older than 35 years. CONCLUSIONS: With the current work, we have gathered data and information on the ways through which individuals in SSA interact, and on the factors that mostly facilitate this interaction. Monitoring these processes is critical to realistically predict the effects of interventions on infectious diseases dynamics

ABUNDANCIA Y DIVERSIDAD DE AVES EN AMBIENTES CON DIFERENTE GRADO DE PERTURBACIÓN EN EL MONTE DE ARGENTINA

RESUMEN ∙ Las modificaciones antrópicas en el ecosistema suelen tener un impacto importante en su fauna. Estudios ecológicos consideran a las aves como buenas indicadoras de estos cambios. Sin embargo, en ambientes áridos y semiáridos de América del Sur estos estudios son limitados. En este trabajo analizamos los cambios en la riqueza y abundancia de aves en función de ambientes con diferente grado de perturbación antrópica, de las estaciones del año y de la velocidad del viento. El área de estudio está ubicada en la localidad Villa Aberastain, Pocito, San Juan, Argentina. Los muestreos se realizaron en transectas en tres ambientes contrastantes (Zona Rural, Llanura Pedemontana y Quebrada Precordillerana) y en tres momentos de las estaciones del año (otoño–invierno, primavera y verano). Detectamos 41 especies de aves, pertenecientes a 22 familias. La riqueza y la abundancia de aves fueron mayores en el ambiente más perturbado (Zona Rural). La abundancia de aves fue mayor durante la primavera, mientras que la riqueza no varió de manera significativa a lo largo del tiempo. El gremio de aves granívoras fue el más abundante y junto con las aves insectívoras de sustrato presentaron el mayor número de especies. Las aves nectarívoras mostraron una mayor abundancia y riqueza en ambientes de quebradas precordillerana, mientras que las insectívoras de sustrato lo fueron en ambientes con mayor perturbación (Zona Rural). En todos los casos, la abundancia de aves fue menor a mayor intensidad de viento. Al igual que en otros estudios, los ambientes con modificaciones antrópicas del desierto del Monte presentan comunidades de aves diferentes a los ambientes naturales circundantes, con mayor riqueza pero también con mayor abundancia de especies introducidas (Columba livia y Passer domesticus).ABSTRACT ∙ Abundance and diversity of birds in environments with different degrees of human disturbance in the Argentine Monte Anthropic ecosystem modifications usually have considerable impact on the resident fauna. Ecological studies have recognized birds as good indicators of these changes; nevertheless, little research has been conducted regarding the consequences of disturbance specifically on arid and semi‐arid environments of South America. This study analyzes how various parameters, including differing degrees of anthropic modification, seasonal variation, and wind velocity, affect richness and abundance of bird species as well as trophic guilds in the Monte ecoregion of San Juan, Argentina. We recorded 41 bird species during our surveys, belonging to 22 families. The most human‐modified environments had the highest levels of richness and abundance. Bird abundance was highest in spring, while richness did not vary significantly with season. The granivorous guild was the most abundant and, together with the ground‐foraging insectivores and granivorous‐insectivores, represented the majority of the species (58.5%). Aerial‐feeding insectivores and nectarivores were more common in mountain ravines while ground‐foraging insectivorous species were mainly found in human‐modified areas. In all cases, higher wind speed correlated with reduced bird abundance. Even though bird richness and abundance were highest in modified environments, these habitats harbored bird communities that differed substantially from surrounding natural environments, and with dominance of introduced species (Columbia livia, Passer domesticus)

Psychosocial determinants of recovery in depression

There is a growing body of literature on residual symptoms after apparently successful treatment The strong prognostic value of subthreshold symptomatology upon remission and the relationship between residual and prodromal symptomatology (the rollback phenomenon) have been outlined. Most residual symptoms also occur in the prodromal phase of depression and may progress to become prodromes of relapse. These findings entail important implications. It is necessary to closely monitor the patient throughout the different phases of illness and to assess the quality and extent of residual symptoms. A more stringent definition of recovery, which is not limited to symptomatic assessment, but includes psychological well-being, seems to be necessary. Wen therapeutic strategies for improving the level of remission, such as treatment of residual symptoms that progress to become prodromes of relapse and/or increasing psychological well-being, appear to yield more lasting benefits. The sequential model may provide room for innovative treatment approaches, including the use of drugs for specifically addressing residual symptoms. As occurs in other medical disorders (such as diabetes and hypertension), the active role of the patient in achieving recovery (self-therapy homework) should be pursued

Operation of a LAr-TPC equipped with a multilayer LEM charge readout

A novel detector for the ionization signal in a single phase LAr-TPC, based on the adoption of a multilayer Large Electron Multiplier (LEM) replacing the traditional anodic wire arrays, has been experimented in the ICARINO test facility at the INFN Laboratories in Legnaro. Cosmic muon tracks were detected allowing the measurement of energy deposition and a first determination of the signal to noise ratio. The analysis of the recorded events demonstrated the 3D reconstruction capability of ionizing events in this device in liquid Argon, collecting a fraction of about 90% of the ionization signal with signal to noise ratio similar to that measured with more traditional wire chambersComment: 9 pages, 7 Figure