A written self-help intervention for depressed adults comparing behavioural activation combined with physical activity promotion with a self-help intervention based upon behavioural activation alone: study protocol for a parallel group pilot randomised controlled trial (BAcPAc).

BACKGROUND: Challenges remain to find ways to support patients with depression who have low levels of physical activity (PA) to overcome perceived barriers and enhance the perceived value of PA for preventing future relapse. There is an evidence-base for behavioural activation (BA) for depression, which focuses on supporting patients to restore activities that have been avoided, but practitioners have no specific training in promoting PA. We aimed to design and evaluate an integrated BA and PA (BAcPAc) practitioner-led, written, self-help intervention to enhance both physical and mental health. METHODS/DESIGN: This study is informed by the Medical Research Council Complex Intervention Framework and describes a protocol for a pilot phase II randomised controlled trial (RCT) to test the feasibility and acceptability of the trial methods to inform a definitive phase III RCT. Following development of the augmented written self-help intervention (BAcPAc) incorporating behavioural activation with physical activity promotion, depressed adults are randomised to receive up to 12 sessions over a maximum of 4 months of either BAcPAc or behavioural activation alone within a written self-help format, which represents treatment as usual. The study is located within two \u27Improving Access to Psychological Therapies\u27 services in South West England, with both written self-help interventions supported by mental health paraprofessionals. Measures assessed at 4, 9, and 12 month follow-up include the following: CIS-R, PHQ-9, accelerometer recorded (4 months only) and self-reported PA, body mass index, blood pressure, Insomnia Severity Index, quality of life, and health and social care service use. Process evaluation will include analysis of recorded support sessions and patient and practitioner interviews. At the time of writing the study has recruited 60 patients. DISCUSSION: The feasibility outcomes will inform a definitive RCT to assess the clinical and cost-effectiveness of the augmented BAcPAc written self-help intervention to reduce depression and depressive relapse, and bring about improvements across a range of physical health outcomes. TRIAL REGISTRATION: Current Controlled Trials ISRCTN74390532, 26.03.2013

A written self-help intervention for depressed adults comparing behavioural activation combined with physical activity promotion with a self-help intervention based upon behavioural activation alone: study protocol for a parallel group pilot randomised controlled trial (BAcPAc)

notes: PMCID: PMC4061537types: Journal Article© 2014 Farrand et al.; licensee BioMed Central Ltd.Challenges remain to find ways to support patients with depression who have low levels of physical activity (PA) to overcome perceived barriers and enhance the perceived value of PA for preventing future relapse. There is an evidence-base for behavioural activation (BA) for depression, which focuses on supporting patients to restore activities that have been avoided, but practitioners have no specific training in promoting PA. We aimed to design and evaluate an integrated BA and PA (BAcPAc) practitioner-led, written, self-help intervention to enhance both physical and mental health.NPRI-

UK-SCAPE flux tower network: monitoring terrestrial greenhouse gas, water and energy balance

To predict, assess and mitigate the impacts of anthropogenic climate change, it is essential to (i) understand the drivers and dynamics of terrestrial carbon sequestration, greenhouse gas (GHG) emission and energy balance at site scale; and (ii) to deploy standardised observation networks to quantify flux variability in space and time. Under UK-SCAPE, CEH continuously monitors long-term GHG, water and energy balance across a network of eddy covariance (EC) sites using harmonised protocols, data processing and quality assurance

COSMOS-UK user guide: users’ guide to sites, instruments and available data (version 2.10)

The COSMOS-UK User Guide is a comprehensive guide to the data collected by COSMOS-UK, including the near-real time soil moisture data derived from counts of netrons derived from cosmic rays. The User Guide contains: i) information about the sites, their locations and other meta data. ii) Details of the instruments deployed at each site. iii) Background information about the cosmic ray neutron counter which is used to derive soil moisture within a 12 hectare footprint. iv) Descriptions of data and information products that are available from COSMOS-UK

Two Opines Control Conjugal Transfer of an Agrobacterium Plasmid by Regulating Expression of Separate Copies of the Quorum-Sensing Activator Gene traR

International audienc

Co-evolution of the agrocinopine opines and the agrocinopine-mediated control of TraR, the quorum-sensing activator of the Ti plasmid conjugation system

International audienc

Quorum-sensing system of Agrobacterium plasmids: Analysis and utility

International audienc

Agrobacterium is a definable genus of the family Rhizobiaceae

International audienc

Octopine-type Ti plasmids code for a mannopine-inducible dominant-negative allele of traR, the quorum-sensing activator that regulates Ti plasmid conjugal transfer

International audienc

The Bases of Crown Gall Tumorigenesis

International audienc